http://www.medconnect.com.my/default.aspxThe latest Journal Scans.Copyright 2005 - 2009 EPMI. All rights reserved.For many families around the world, the difficulties and costs associated with dementia are painfully real. Yet in some countries governments and policymakers remain in denial about the urgent need to plan for a future in which dementia will be increasingly common. A report published by WHO on...http://www.medconnect.com.my/tabid/100/ct9/c458696/-Editorial-Public-health-planning-for-dementia-must-start-now/Default.aspx01-Jun-2012Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a disease of peripheral nerves that can cause substantial disability for long periods of time. The primary goal in treating chronic diseases should be a sustained clinically meaningful improvement or remission without long-term...http://www.medconnect.com.my/tabid/100/ct9/c458697/-Comment-First-line-treatment-for-CIDP-a-new-piece-of-the-puzzle/Default.aspx01-Jun-2012Previous stroke or transient ischaemic attack (TIA) is the most powerful independent predictor of stroke in patients with atrial fibrillation (AF), with an annual rate of subsequent stroke of between 6% and 10% per year in the absence of anticoagulation. The rate seems to be lower for patients with...http://www.medconnect.com.my/tabid/100/ct9/c458698/-Comment-Reducing-the-risk-of-recurrent-stroke-in-patients-with-AF/Default.aspx01-Jun-2012Vitamin B12 and folate are key mediators of homocysteine metabolism. Low plasma vitamin B12 and folate concentrations are associated with hyperhomocysteinaemia, with consequent premature atherosclerosis and increased risk of cardiovascular and cerebrovascular disease. The Heart Outcomes Prevention...http://www.medconnect.com.my/tabid/100/ct9/c458699/-Comment-Unmasking-the-benefits-of-B-vitamins-in-stroke-prevention/Default.aspx01-Jun-2012As noted by Tobias Kurth and colleagues in a recent Review in The Lancet Neurology, familial hemiplegic migraine is, in some instances, attributable to mutations in the CACNA1A gene; transgenic mice expressing the human Arg192Gln or Ser218Leu mutations in CaV2.1 voltage-gated calcium channels,...http://www.medconnect.com.my/tabid/100/ct9/c458700/-Correspondence-Stroke-and-familial-hemiplegic-migraine/Default.aspx01-Jun-2012The WHO International Classification of Diseases (ICD) provides a taxonomy of nearly all known human diseases, based on the best available evidence. The ICD is the international standard for diagnostic classification and ensures comparable reporting of health data and the homogenous compilation of...http://www.medconnect.com.my/tabid/100/ct9/c458701/-Correspondence-Neurological-disorders-in-the-11th-revision-of-the/Default.aspx01-Jun-2012After decades in the wilderness, recent coverage of the rehabilitation of American Congresswoman Gabrielle Giffords might have given music therapy its breakthrough moment. David Holmes reports.http://www.medconnect.com.my/tabid/100/ct9/c458702/-In-Context-Music-therapys-breakthrough-act/Default.aspx01-Jun-2012Recurrent stroke prevention (Article, April)Hankey GJ, Patel MR, Stevens SR, et al. Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. Lancet Neurol 2012; 11: 315–22.Cerebral microinfarcts...http://www.medconnect.com.my/tabid/100/ct9/c458703/-In-Context-March-2012/Default.aspx01-Jun-2012As part of a series about neuroethics, the Wellcome Collection held three evening events in February and March that were designed to provoke discussion between a panel of experts and members of the public. Short presentations by the speakers were followed by question-and-answer sessions. I attended...http://www.medconnect.com.my/tabid/100/ct9/c458704/-In-Context-Neuroethics-consciousness-and-courtrooms/Default.aspx01-Jun-2012British documentary maker Louis Theroux is in the kitchen of John and Nancy Vaughn, two elderly residents of Phoenix, Arizona. “Do you forget much?” Theroux asks Nancy. “Not very much”, is the reply. “What's your name Nancy?” asks John. A long pause. “Nancy…umm…Bread.” Nancy, who looks young for...http://www.medconnect.com.my/tabid/100/ct9/c458705/-In-Context-Extreme-love-dementia/Default.aspx01-Jun-2012Treatment of CIDP with IVIg for 6 months was less frequently discontinued because of inefficacy, adverse events, or intolerance than was treatment with intravenous methylprednisolone. The longer-term effects of these treatments on the course of CIDP need to be addressed in future studies.http://www.medconnect.com.my/tabid/100/ct9/c458706/-Articles-Intravenous-immunoglobulin-versus-intravenous-methylprednisolone-for/Default.aspx01-Jun-2012The effects of apixaban versus warfarin were consistent in patients with AF with and without previous stroke or TIA. Owing to the higher risk of these outcomes in patients with previous stroke or TIA, the absolute benefits of apixaban might be greater in this population.http://www.medconnect.com.my/tabid/100/ct9/c458707/-Articles-Apixaban-compared-with-warfarin-in-patients-with-atrial/Default.aspx01-Jun-2012Our findings support the hypothesis that antiplatelet therapy modifies the potential benefits of lowering homocysteine with B-vitamin supplementation in the secondary prevention of major vascular events. If validated, B vitamins might have a role in the prevention of ischaemic events in high-risk...http://www.medconnect.com.my/tabid/100/ct9/c458708/-Articles-Antiplatelet-therapy-and-the-effects-of-B-vitamins/Default.aspx01-Jun-2012Diabetic peripheral neuropathy is a prevalent, disabling disorder. The most common manifestation is distal symmetrical polyneuropathy (DSP), but many patterns of nerve injury can occur. Currently, the only effective treatments are glucose control and pain management. While glucose control...http://www.medconnect.com.my/tabid/100/ct9/c458709/-Review-Diabetic-neuropathy-clinical-manifestations-and-current-treatments/Default.aspx01-Jun-2012Neuromyelitis optica is an inflammatory demyelinating disorder of the CNS. The discovery of circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) and the evidence that AQP4-IgG is involved in the development of neuromyelitis optica revolutionised our...http://www.medconnect.com.my/tabid/100/ct9/c458710/-Review-Aquaporin-4-and-neuromyelitis-optica/Default.aspx01-Jun-2012The non-fluent/agrammatic variant of primary progressive aphasia (naPPA) is a young-onset neurodegenerative disorder characterised by poor grammatical comprehension and expression and a disorder of speech sound production. In an era of disease-modifying treatments, the identification of naPPA might...http://www.medconnect.com.my/tabid/100/ct9/c458711/-Review-The-non-fluent-agrammatic-variant-of-primary-progressive-aphasia/Default.aspx01-Jun-2012Cerebral palsy is caused by injury or developmental disturbances to the immature brain and leads to substantial motor, cognitive, and learning deficits. In addition to developmental disruption associated with the initial insult to the immature brain, injury processes can persist for many months or...http://www.medconnect.com.my/tabid/100/ct9/c458712/-Review-Tertiary-mechanisms-of-brain-damage-a-new-hope/Default.aspx01-Jun-2012The prevalence of pelvic fracture in patients with blunt trauma is between 5% and 16%. A significant proportion of deaths from pelvic fracture are due to exsanguination and patients who are haemodynamically unstable on arrival to the Emergency Department have a much higher mortality rate than the...http://www.medconnect.com.my/tabid/100/ct9/c454478/The-use-of-pelvic-binders-in-the-emergent-management-of-potential-pelvic-trauma/Default.aspx01-Jun-2012Abstract: Ischemia reperfusion (IR) injury occurs when tissue is reperfused following a period of ischemia, and results from acute inflammation involving various mechanisms. IR injury can occur following a range of circumstances, ranging from a seemingly minor condition to major trauma. The intense...http://www.medconnect.com.my/tabid/100/ct9/c454479/The-effect-of-ischemia-reperfusion-injury-on-skeletal-muscle/Default.aspx01-Jun-2012Abstract: Background: Hip fractures are always associated with a high postoperative mortality, the preoperative predictors for mortality have neither been well identified or summarised. This systematic review and meta-analysis was performed to identify the preoperative non-interventional predictors...http://www.medconnect.com.my/tabid/100/ct9/c454480/Preoperative-predictors-for-mortality-following-hip-fracture-surgery-A/Default.aspx01-Jun-2012As senior editor for head-and-neck cancer, I have the pleasure of working with an incredible team of 4 outstanding associate editors. The associate editors read the manuscripts and together we decide whether the manuscript should be sent out for formal review. If there is a consensus by the editors...http://www.medconnect.com.my/tabid/100/ct9/c456074/Oncology-Scan-Head-and-Neck-Cancers/Default.aspx01-Jun-2012To the Editor: The current conventional dose for esophageal primaries is suboptimal, as argued by Welsh et al . Doses can be escalated by either 3-dimensional conformal radiation therapy (3DCRT) or simultaneous integrated boost intensity modulated radiation therapy (SIB-IMRT).http://www.medconnect.com.my/tabid/100/ct9/c456075/Different-Dose-Escalation-Protocols-for-Esophageal-Primaries-Like-Comparing/Default.aspx01-Jun-2012To the Editor: I read with interest the article by Dr. Abdollah and colleagues , and I commend them for their efforts. Several issues deserve comment. First, the authors calculate the area under the curve (AUC) of the receiver operating characteristic curve of the Roach formula to be 80.3%, and...http://www.medconnect.com.my/tabid/100/ct9/c456076/In-regard-to-Indications-for-Pelvic-Nodal-Treatment-in/Default.aspx01-Jun-2012To the Editor: The authors presented the updated results of an accelerated partial breast irradiation (APBI) phase I–II dose-escalation study using interstitial low-dose-rate brachytherapy (IB) for early-stage breast cancer . They reported poor cosmetic results and significant toxicity for high...http://www.medconnect.com.my/tabid/100/ct9/c456077/In-regard-to-Hattangadi-et al-Int-J-Radiat-Oncol/Default.aspx01-Jun-2012To the Editor: We read with great interest the article by Zhou et al , in which they reported that baseline serum lactate dehydrogenase (LDH) levels are a predictor of poor prognosis and subsequent liver metastasis in patients treated with intensity-modulated radiation therapy (IMRT) for...http://www.medconnect.com.my/tabid/100/ct9/c456078/In-regard-to-Zhou-et al-Baseline-Serum-Lactate-Dehydrogenase/Default.aspx01-Jun-2012To the Editor: We commend the RTOG radiation oncologists who arrived at a consensus for target volume delineation for preoperative sarcoma radiation therapy that generally follows the protocol for their recently completed RTOG 0630 trial , for which we all await local control results. Of interest...http://www.medconnect.com.my/tabid/100/ct9/c456079/In-regard-to-RTOG-Sarcoma-Radiation-Oncologists-Reach-Consensus-on/Default.aspx01-Jun-2012Clavel et al have stoked a controversial debate for neck dissection in complete responders after definitive chemoradiation in head-and-neck cancers, echoed in an accompanying editorial . Although applied radiologic criteria as predictive markers seem robust, at best, imaging is still a...http://www.medconnect.com.my/tabid/100/ct9/c456080/Need-for-Neck-Dissection-A-Premature-Epitaph-for-obsolete/Default.aspx01-Jun-2012To the Editor: We appreciate the effort of Dr. Kong et al to provide some uniformity for normal tissue delineation for thoracic tumors—clearly a worthwhile goal. However, we have one concern regarding the esophagus.http://www.medconnect.com.my/tabid/100/ct9/c456081/Esophageal-Delineation-In-regard-to-Kong-et al-Consideration-of/Default.aspx01-Jun-2012Purpose: To identify a cohort of women treated with neoadjuvant chemotherapy and mastectomy for whom postmastectomy radiation therapy (PMRT) may be omitted according to the projected risk of local-regional failure (LRF).Methods and Materials: Seven breast cancer physicians from the University of...http://www.medconnect.com.my/tabid/100/ct9/c456083/Role-of-Postmastectomy-Radiation-After-Neoadjuvant-Chemotherapy-in-Stage/Default.aspx01-Jun-2012Background: Accelerated whole-breast radiotherapy (RT) with tumor bed boost in the treatment of early invasive breast cancer has demonstrated equivalent local control and cosmesis when compared with standard RT. Its efficacy in the treatment of ductal carcinoma in situ (DCIS) remains...http://www.medconnect.com.my/tabid/100/ct9/c456088/Five-Year-Outcome-of-145-Patients-With-Ductal-Carcinoma/Default.aspx01-Jun-2012Purpose: In large stage III lung tumors, planning delivery of doses exceeding 60 Gy can be challenging and time consuming. Intensity modulated radiation therapy (IMRT) can improve target coverage but may increase volumes receiving low-dose irradiation. We clinically implemented a novel hybrid IMRT...http://www.medconnect.com.my/tabid/100/ct9/c456174/Clinical-Application-of-a-Novel-Hybrid-Intensity-Modulated-Radiotherapy-Technique-for/Default.aspx01-Jun-2012Human papillomavirus (HPV) is responsible for common condyloma acuminata and a number of premalignant and malignant anogenital lesions. These conditions are of particular concern in immunocompromised individuals who have higher risk of malignant transformation and are more difficult to treat. This...http://www.medconnect.com.my/tabid/100/ct9/c457229/Human-papillomavirus-related-genital-disease-in-the-immunocompromised-host-Part-I/Default.aspx01-Jun-2012Human papillomavirus is responsible for common condyloma acuminata and a number of premalignant and malignant anogenital lesions. The immunocompromised population is at particular risk because of a higher incidence of malignant transformation. Lesions in this population may prove refractory to...http://www.medconnect.com.my/tabid/100/ct9/c457230/Human-papillomavirus-related-genital-disease-in-the-immunocompromised-host-Part-II/Default.aspx01-Jun-2012 A respected physician affiliated with an academic medical center is shopping at a local gift shop with his spouse. The physician is being helped by the owner of the shop, a fair-skinned woman that he estimates to be in her mid-forties. During this interaction, the physician cannot help but notice...http://www.medconnect.com.my/tabid/100/ct9/c457242/The-unsolicited-ominous-diagnosis-Legal-moral-and-ethical-considerations/Default.aspx01-Jun-2012To the Editor: Reiter et al provide a comprehensive review of treatment options for calcinosis cutis (CC). However, they do not discuss the role of hematopoietic stem cell transplantation (HSCT), a treatment modality that has shown some promise in this condition and may have an increasing role as a...http://www.medconnect.com.my/tabid/100/ct9/c457245/Calcinosis-cutis-An-additional-therapy-to-consider/Default.aspx01-Jun-2012To the Editor: We read with great interest the article by Tziotzios and colleagues describing strategies to reduce cutaneous scarring, published in January 2012. This valuable review article very briefly touches on fractional laser therapy for scars, and comments that “there is a limited evidence...http://www.medconnect.com.my/tabid/100/ct9/c457246/Evidence-for-fractional-laser-treatment-in-the-improvement-of-cutaneous-scars/Default.aspx01-Jun-2012To the Editor: Sunscreens and sunblocks are significant means of protection from the cutaneous damages imparted by ultraviolet radiation (UVR). Chemical sunscreens, as opposed to physical sunblocks, typically consist of a combination of lipophilic organic compounds in order to absorb the broad UVR...http://www.medconnect.com.my/tabid/100/ct9/c457247/Stability-of-sunscreens-and-sunblocks-following-exposure-to-extreme-temperatures/Default.aspx01-Jun-2012To the Editor: Monitoring the severity of atopic dermatitis (AD) is crucial to disease management. Tools exist to assess disease severity for experimental studies; these tools are not practical in a high-volume clinical setting. Thus, a simple bedside marker of AD severity would be a useful...http://www.medconnect.com.my/tabid/100/ct9/c457248/The-infra-auricular-fissure-A-bedside-marker-of-disease-severity/Default.aspx01-Jun-2012To the Editor: While the varicella-zoster virus (VZV; chickenpox) vaccine (Varivax) is widely utilized and has produced a dramatic decline in VZV-related morbidity and mortality, the herpes zoster virus (HZV) (shingles) vaccine (Zostavax) is used in only 2% to 7% of the target population over 50...http://www.medconnect.com.my/tabid/100/ct9/c457249/Refusal-of-shingles-vaccine-Implications-for-public-health/Default.aspx01-Jun-2012To the Editor: Psoriasis is an inflammatory skin disease that affects approximately 2% of the general population, and roughly 1% of children. Numerous large population-based studies have demonstrated the systemic effects of psoriatic disease in adults showing an increased risk of coronary artery...http://www.medconnect.com.my/tabid/100/ct9/c457250/Association-between-pediatric-psoriasis-and-the-metabolic-syndrome/Default.aspx01-Jun-2012To the Editor: Lipodermatosclerosis (LDS) is believed to be associated with chronic venous insufficiency. Abnormal fibrinolysis, the excessive proteolytic activity by matrix metalloproteinase, and the up-regulation of inflammatory response by interleukin-8 are thought to be the causes for this...http://www.medconnect.com.my/tabid/100/ct9/c457251/Lipodermatosclerosis-Improvement-noted-with-hydroxychloroquine-and-pentoxifylline/Default.aspx01-Jun-2012To the Editor: Dermatophytoma is a little-known microscopic manifestation of fungal nail infection only recently mentioned in the literature. It is characterized by abundant fungal filaments, large spores, or both, compacted and forming a fungal ball. Definitive diagnosis is made microscopically by...http://www.medconnect.com.my/tabid/100/ct9/c457252/Dermatophytoma-Description-of-7-cases/Default.aspx01-Jun-2012A 63-year-old man presented with erythematous papules in a linear distribution (). Each linear lesion persisted beyond 24 hours. He complained of severe itching but otherwise felt well. A complete blood cell count revealed no pathologic findings. The patient denied taking any oral medications. On...http://www.medconnect.com.my/tabid/100/ct9/c457254/Linear-erythematous-papules-from-previous-scratching/Default.aspx01-Jun-2012An 18-year-old woman developed an asymptomatic rash 2 weeks after having a tattoo applied that preferentially affected both the red and black areas of the tattoo. There was no history of a sore throat or other infections. The physical examination revealed white scaling overlying the areas where...http://www.medconnect.com.my/tabid/100/ct9/c457255/A-scaling-rash-preferentially-involving-a-recent-tattoo/Default.aspx01-Jun-2012To the Editor: Chemical leukoderma is a chemically induced acquired hypopigmented dermatosis. We report a case of chemical leukoderma induced by a transdermal methylphenidate medicated patch for the treatment of attention deficit hyperactive disorder (ADHD).http://www.medconnect.com.my/tabid/100/ct9/c457264/Chemical-leukoderma-after-the-application-of-a-transdermal-methylphenidate-patch/Default.aspx01-Jun-2012To the Editor: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) has been described as a distinct clinicopathologic entity in the last World Health Organization classification of tumors of hematopoietic and lymphoid tissue. It is a very rare neoplasm, even more infrequent in children than in...http://www.medconnect.com.my/tabid/100/ct9/c457266/Blastic-plasmacytoid-dendritic-cell-neoplasm-in-a-child/Default.aspx01-Jun-2012To the Editor: A 32-year-old woman with acute myelogenous leukemia presented with a 2-month history of subtle papules on her cheeks and forehead 100 days after allogenic bone-marrow transplantation (). She was on cyclosporine for graft-versus-host disease prophylaxis. A punch biopsy specimen from...http://www.medconnect.com.my/tabid/100/ct9/c457267/Mycosis-fungoides-associated-follicular-mucinosis-after-bone-marrow-transplantation/Default.aspx01-Jun-2012To the Editor: Onychopapilloma is a benign neoplasm of the distal matrix and the nail bed. It typically presents with longitudinal erythronychia with hemorrhagic lines. One case of onychopapilloma causing longitudinal leukonychia has also been published.http://www.medconnect.com.my/tabid/100/ct9/c457268/Onychopapilloma-presenting-as-longitudinal-melanonychia/Default.aspx01-Jun-2012To the Editor: Pemphigus foliaceus is a well-defined clinical disease that has been linked to thymic neoplasmsm; however, most cases are idiopathic in origin. The purpose of this letter is to describe a novel observation of an association between pemphigus foliaceus and uterine fibroids.http://www.medconnect.com.my/tabid/100/ct9/c457270/Pemphigus-foliaceus-clearance-status-postmyomectomy-for-an-enlarged-infarcted/Default.aspx01-Jun-2012To the Editor: A 13-year-old African American girl presented with a history of several keloidal scars arising in areas of previously normal-appearing skin involving the face, neck, trunk, and lower and upper extremities. History of trauma, piercings, or acne was negative. The lesions arose...http://www.medconnect.com.my/tabid/100/ct9/c457271/Nodular-scleroderma-presenting-as-multiple-spontaneous-keloidal-scars/Default.aspx01-Jun-2012To the Editor: A 78-year-old woman with a history of sacral chordoma presented 2 years after wide local resection with multiple rubbery, flesh-colored, nodular lesions of the scalp measuring 0.9 × 0.7 × 0.5 cm, 0.6 × 0.5 × 0.5 cm, and 0.5 × 0.4 × 0.4 cm, and one 0.8 × 0.7 × 0.6 cm rubbery gray...http://www.medconnect.com.my/tabid/100/ct9/c457273/Multiple-cutaneous-metastatic-chordomas-from-the-sacrum/Default.aspx01-Jun-2012To the Editor: A 68-year-old man presented with a 2-month history of progressing plaques on his right arm after he had punctured the tip of his fourth finger with a fishhook. A first plaque had appeared on his forearm 1 month after the injury and two others appeared successively in a sporotrichoid...http://www.medconnect.com.my/tabid/100/ct9/c457274/Mycobacterium-celatum-skin-infection-with-sporotrichoid-spread-in-an/Default.aspx01-Jun-2012To the Editor: Anticonvulsant hypersensitivity syndrome is an adverse and potentially fatal condition associated with the use of certain anticonvulsants. It is characterized by the presence of fever, generalized cutaneous eruption, lymphadenopathy, and internal organ involvement. We present the...http://www.medconnect.com.my/tabid/100/ct9/c457275/Successful-treatment-of-lamotrigine-associated-drug-hypersensitivity-syndrome-with/Default.aspx01-Jun-2012To the Editor: Dowling-Degos disease (DDD) is a rare autosomal dominant genodermatosis with variable penetrance. It is characterized by reticular hyperpigmentation and pruritic follicular hyperkeratotic papules in the axillae, groin, and other body folds. Comedo-like lesions on the back or neck,...http://www.medconnect.com.my/tabid/100/ct9/c457276/Galli-Galli-disease-is-an-acantholytic-variant-of-Dowling-Degos-disease-/Default.aspx01-Jun-2012To the Editor: We describe a patient with severe psoriasis whose skin lesions regressed after the oral administration of erlotinib, an epidermal growth factor receptor (EGFR)-specific tyrosine kinase inhibitor (TKI), for the treatment of metastatic lung adenocarcinoma.http://www.medconnect.com.my/tabid/100/ct9/c457277/A-case-of-rapid-improvement-of-severe-psoriasis-during/Default.aspx01-Jun-2012Aesthetic Rejuvenation: A Regional Approach edited by Ranell Hirsch, Neil Sadick, and Joel L. Cohen is a lightweight, but comprehensive, easy-to-use textbook. The book's focus is on specific regions of the body, giving practitioners a way to effectively determine the most appropriate procedure,...http://www.medconnect.com.my/tabid/100/ct9/c457278/Aesthetic-rejuvenation-A-regional-approach/Default.aspx01-Jun-2012Magro et al have succeeded in filling a vacuum in our libraries. This is the first truly comprehensive book on the subject of lymphoid-rich infiltrates of the skin covering the entire spectrum of cutaneous pathology from benign dermatoses to malignant lymphomas, including a section on cutaneous...http://www.medconnect.com.my/tabid/100/ct9/c457279/The-cutaneous-lymphoid-proliferations-A comprehensive-textbook-of-lymphocytic/Default.aspx01-Jun-2012In the late decades of the 18th century, the ravages of syphilis and other contagions aroused widespread public alarm. Syphilis and other venereal diseases were rampant. Scabies was endemic. Many disorders of the skin were thought to be signs of the dreaded leprosy. Clinics for skin disorders were...http://www.medconnect.com.my/tabid/100/ct9/c457280/History-of-German-language-dermatology/Default.aspx01-Jun-2012Tumorigenic melanocytic proliferations, by David Elder, is part of the Consultant Pathology series published by Demos Medical Publishing. Given that most medical titles are now published by Elsevier or Wolters Kluwer, this book might escape notice during a casual stroll down publisher's row at the...http://www.medconnect.com.my/tabid/100/ct9/c457281/Consultant-pathology-Tumorigenic-melanocytic-proliferations/Default.aspx01-Jun-2012Abstract: Intramedullary nailing is gradually emerging as the treatment of choice for pertrochanteric femoral fractures. Nevertheless, prospective randomised trials have failed to demonstrate the assumed superiority of cephalomedullary nails over the traditional treatment with the sliding hip...http://www.medconnect.com.my/tabid/100/ct9/c454481/Evolving-concepts-of-stability-and-intramedullary-fixation-of-intertrochanteric/Default.aspx01-Jun-2012Abstract: Articular cartilage has a very limited capacity to repair and as such premature joint degeneration is often the end point of articular injuries. Patients with chondral injury have asymptomatic periods followed by others in which discomfort or pain is bearable. The repair of focal...http://www.medconnect.com.my/tabid/100/ct9/c454482/Knee-chondral-injuries-Clinical-treatment-strategies-and-experimental-models/Default.aspx01-Jun-2012Abstract: Introduction: A sliding hip screw (SHS) is currently the treatment of choice for trochanteric hip fractures, largely due to the low incidence of complications. An alternative treatment is the use of intramedullary proximal femoral nails. Unfortunately these implants have been associated...http://www.medconnect.com.my/tabid/100/ct9/c454483/Occurrence-of-secondary-fracture-around-intramedullary-nails-used-for/Default.aspx01-Jun-2012Abstract: Purpose: Any torsion experienced at a fracture site will directly translate into shearing forces and has been regarded as detrimental to healing. The purpose of this study was to determine which plating system currently on the market controls torsional forces about comminuted olecranon...http://www.medconnect.com.my/tabid/100/ct9/c454484/Quantifying-and-comparing-torsional-strains-after-olecranon-plating/Default.aspx01-Jun-2012Abstract: Objective: Fixation of ankle fractures in elderly patients is associated with reduced stability conditioned by osteoporotic bone. Therefore, fixation with implants providing improved biomechanical features could allow a more functional treatment, diminish implant failure and avoid...http://www.medconnect.com.my/tabid/100/ct9/c454487/A-contoured-locking-plate-for-distal-fibular-fractures-in/Default.aspx01-Jun-2012Abstract: The purpose of this study was to translate and culturally adapt the Dutch version of the Short Musculoskeletal Function Assessment questionnaire (SMFA-NL) and to investigate the internal consistency, validity, repeatability and responsiveness of the translated version.The original SMFA...http://www.medconnect.com.my/tabid/100/ct9/c454492/Cross-cultural-adaptation-of-the-Dutch-Short-Musculoskeletal-Function-Assessment/Default.aspx01-Jun-2012Abstract: Objectives: Locking plate fixation of humeral head fractures bares the risk of glenohumeral screw penetration. In order to circumvent this problem it is recommended to insert shorter locking screws having at least a 6mm distance to the humeral head cortex. This in turn may reduce fixation...http://www.medconnect.com.my/tabid/100/ct9/c454498/Locking-plate-fixation-of-humeral-head-fractures-with-a/Default.aspx01-Jun-2012Abstract: Objectives: To describe the experience in the development of an electronic emergency department (ED)-based injury surveillance (IS) system in Hong Kong using data-mining and geo-spatial information technology (IT) for a Safe Community setup.Methods: This paper described the phased...http://www.medconnect.com.my/tabid/100/ct9/c454499/Development-of-an-electronic-emergency-department-based-geo-information-injury/Default.aspx01-Jun-2012Abstract: Objectives: We investigated the accuracy of reduction of intramedullary nailed femoral shaft fractures in human cadavers, comparing conventional and computer navigation techniques.Methods: Twenty femoral shaft fractures were created in human cadavers, with segmental defects ranging from 9...http://www.medconnect.com.my/tabid/100/ct9/c454500/Computer-navigation-in-the-reduction-and-fixation-of-femoral/Default.aspx01-Jun-2012Abstract: Purpose: There has been considerable concern regarding radiation exposure to both the patient and treating surgeon and the possible risk of resulting malignancy. We sought to analyse the total effective dose of radiation that a cohort of orthopaedic trauma patients are exposed to during...http://www.medconnect.com.my/tabid/100/ct9/c454503/Analysis-of-radiation-exposure-to-the-orthopaedic-trauma-patient/Default.aspx01-Jun-2012Abstract: Introduction: Fractures in children are the second most common presentation of child abuse. In younger children, especially in those less than 18 months, fractures should be considered suspicious of a non-accidental injury (NAI). Risk factors associated for abuse are: age younger than 12...http://www.medconnect.com.my/tabid/100/ct9/c454504/The-incidence-of-fractures-in-children-under-the-age/Default.aspx01-Jun-2012Abstract: Introduction: Bed rest with elevation of the affected limb is commonly prescribed postoperatively following ankle fracture fixation although there is no evidence that this is necessary.Aim: The aim of this prospective, randomised study was to investigate the effects of early mobilisation...http://www.medconnect.com.my/tabid/100/ct9/c454505/Rest-easy-Is-bed-rest-really-necessary-after-surgical-repair-of-an-ankle-fracture-/Default.aspx01-Jun-2012Abstract: Background: The timing of soft tissue reconstruction for severe open lower limb trauma is critical to its successful outcome, particularly in the setting of exposed metalware and pre-existing wound infection. The use of negative pressure wound therapy (NPWT) may allow a delay in soft...http://www.medconnect.com.my/tabid/100/ct9/c454506/Early-soft-tissue-coverage-and-negative-pressure-wound-therapy/Default.aspx01-Jun-2012Abstract: The purpose of this study was to determine the long-term incidence of infrapatellar nerve damage after tibial nailing and its relation to anterior knee pain. We retrospectively evaluated 71 patients in whom 72 isolated tibial shaft fractures were treated with an intramedullary nail. The...http://www.medconnect.com.my/tabid/100/ct9/c454507/Injury-to-the-infrapatellar-branch-of-the-saphenous-nerve-/Default.aspx01-Jun-2012Abstract: Introduction: The integral classification of injuries (ICI), by Zwipp et al. has been developed as a classification system for injuries of the bones, joints, cartilage and ligaments of the foot. It follows the principles of the comprehensive classification of fractures by Müller et al....http://www.medconnect.com.my/tabid/100/ct9/c454508/The-ICI-classification-for-calcaneal-injuries-A-validation-study/Default.aspx01-Jun-2012Abstract: Most animal studies of muscle contractile function utilise the anterior or posterior crural muscle (dorsiflexors and plantarflexors, respectively). An advantage to using these muscles is that the common fibular and tibial nerves are readily accessible, while the small size of the crural...http://www.medconnect.com.my/tabid/100/ct9/c454509/An-in-vivo-rodent-model-of-contraction-induced-injury-in-the-quadriceps-muscle/Default.aspx01-Jun-2012Abstract: Loss of oligodendrocytes and demyelination further impair neural function after spinal cord injury (SCI). Replacement of lost oligodendrocytes and improvement of myelination have a therapeutic significance in treatment of SCI. Here, we transplanted oligodendrocyte precursor cells (OPCs)...http://www.medconnect.com.my/tabid/100/ct9/c454512/Transplantation-of-oligodendrocyte-precursor-cells-improves-myelination-and-promotes/Default.aspx01-Jun-2012Abstract: Background: The purpose of this study is to determine the biomechanical stability of a novel prototype femoral neck locking plate (FNLP) for treatment of Pauwels type C femoral neck fractures compared with other current fixation methods.Methods: Forty femur sawbones were divided into...http://www.medconnect.com.my/tabid/100/ct9/c454513/Biomechanical-analysis-of-a-novel-femoral-neck-locking-plate/Default.aspx01-Jun-2012Abstract: Numerous different designs of hemiarthroplasty are available but few have been compared within the context of a randomised controlled trial. Two-hundred patients presenting with a displaced intracapsular fracture of the hip were randomised to receive either a cemented Thompson...http://www.medconnect.com.my/tabid/100/ct9/c454514/Cemented-Thompson-hemiarthroplasty-versus-cemented-Exeter-Trauma-Stem-ETS-/Default.aspx01-Jun-2012Abstract: Introduction: This prospective study was designed to evaluate whether preoperative plasma brain natriuretic peptide (BNP) could identify significant preoperative cardiovascular disease in elderly hip-fractured patients.Patients and methods: Preoperative plasma BNP measurement and rest...http://www.medconnect.com.my/tabid/100/ct9/c454515/Preoperative-plasma-B-type-natriuretic-peptide-BNP-identifies-abnormal/Default.aspx01-Jun-2012Summary: Aims: Recent studies have recommended the use of cephalo-medullary devices for the treatment of reverse oblique intertrochanteric femoral fractures (Orthopaedic Trauma Association/Arbeitsgemeinschaft für Osteosynthesefragen, OTA/AO 31-A3). Both the proximal femoral nail (PFN) and the gamma...http://www.medconnect.com.my/tabid/100/ct9/c454517/Reverse-oblique-intertrochanteric-femoral-fractures-treated-with-the-intramedullary/Default.aspx01-Jun-2012Abstract: Purpose: The aim of the study is to evaluate the surgical technique and clinical significance of the sequential therapy of vacuum sealing drainage (VSD) and free-flap transplantation for children with extensive soft-tissue defects below the knee in the extremities.Methods: Twenty-two...http://www.medconnect.com.my/tabid/100/ct9/c454519/Sequential-therapy-of-vacuum-sealing-drainage-and-free-flap-transplantation/Default.aspx01-Jun-2012Abstract: Background: Accurate prediction of the likelihood of discharge to inpatient rehabilitation following lower limb fracture made on admission to hospital may assist patient discharge planning and decrease the burden on the hospital system caused by delays in decision making.Aims: To develop...http://www.medconnect.com.my/tabid/100/ct9/c454520/Discharge-destination-following-lower-limb-fracture-Development-of-a/Default.aspx01-Jun-2012Abstract: Introduction: Hip injuries are becoming a more common problem as the elderly population increases and their management represents a significant proportion of health care costs. Diagnosis of a fracture based on clinical assessment and plain films is not always conclusive and further...http://www.medconnect.com.my/tabid/100/ct9/c454522/Objective-sound-wave-amplitude-measurement-generated-by-a-tuning-fork-/Default.aspx01-Jun-2012Abstract: Background: Ankle syndesmotic injuries are complex and require anatomic reduction and fixation. Tightrope fixation is a relatively new technique and we present the largest series of syndesmosis fixation using Arthrex Tightrope™ (Naples, FL, USA).Materials and methods: Forty-nine patients...http://www.medconnect.com.my/tabid/100/ct9/c454523/Tightrope-fixation-of-ankle-syndesmosis-injuries-Clinical-outcome-complications-and/Default.aspx01-Jun-2012Abstract: Introduction: Missed compartment syndrome can have devastating long-term impact on a patient's function. Femoral fracture has been reported in 52–58% of acute thigh compartment syndromes in the existing literature. Time to diagnosis of compartment syndrome is cited as a key determinant of...http://www.medconnect.com.my/tabid/100/ct9/c454524/A-national-survey-of-acute-hospitals-in-England-on/Default.aspx01-Jun-2012Abstract: Objectives: Measuring the neck-shaft angle (NSA) and amount of shortening of the femoral neck on the anterior to posterior (AP) X-ray is important when treating proximal femur fractures. To compensate for proximal femoral external rotation, the X-rays need to be taken with the leg...http://www.medconnect.com.my/tabid/100/ct9/c454527/Accuracy-of-in-situ-neck-shaft-angle-and-shortening-measurements/Default.aspx01-Jun-2012Abstract: Introduction: One of the limiting factors in finding the best osteosynthesis approach in proximal humerus fractures is the current lack of information on the properties of the cancellous bone regions engaged by the implants fixing the epiphysis. The aim of this study is to assess the...http://www.medconnect.com.my/tabid/100/ct9/c454529/Where-do-locking-screws-purchase-in-the-humeral-head-/Default.aspx01-Jun-2012Abstract: Background: Successful treatment of intertrochanteric femoral fractures was reportedly influenced by the position of the fixation devices, by reduction quality and by fracture type.Methods: The records of 227 patients with intertrochanteric fractures treated by intramedullary hip screws...http://www.medconnect.com.my/tabid/100/ct9/c454531/Radiological-evaluation-of-intertrochanteric-fracture-fixation-by-the-proximal/Default.aspx01-Jun-2012Abstract: Introduction: Bicondylar tibial plateau fractures can be treated with locked plating applied from the lateral side with or without additional application of a medial plate (dual plating). Recent studies demonstrate that these injuries can be sub-grouped based upon their morphology by...http://www.medconnect.com.my/tabid/100/ct9/c454534/Fracture-pattern-and-fixation-type-related-to-loss-of/Default.aspx01-Jun-2012Abstract: Background: Femoral fractures in adolescents usually need operative treatment, but the optimal method is unclear. The purpose of this study is to compare intramedullary nailing (IN) and submuscular plating (SP) in adolescent femoral fractures.Materials and methods: We performed the...http://www.medconnect.com.my/tabid/100/ct9/c454536/Intramedullary-nailing-versus-submuscular-plating-in-adolescent-femoral-fracture/Default.aspx01-Jun-2012Abstract: Intertrochanteric fractures in elderly patients are always associated with poor prognosis in the functional outcome as a result of the complications and mortality. A retrospective study was performed in our institution, 303 consecutive patients were followed up with mean age of 81.7...http://www.medconnect.com.my/tabid/100/ct9/c454539/Proximal-femoral-nail-antirotation-versus-hemiarthroplasty-A-study-for-the/Default.aspx01-Jun-2012Abstract: Introduction: Collarless, uncemented, femoral stems give excellent results in elective hip replacements but few studies look at outcomes in trauma patients. The presence of osteoporosis and subsequent widened femoral canal may compromise the mechanical stability of uncemented femoral...http://www.medconnect.com.my/tabid/100/ct9/c454541/Subsidence-of-collarless-uncemented-femoral-stems-in-total-hips/Default.aspx01-Jun-2012Abstract: Objective: By analysing the injuries of the orthopaedic wounded during the 2010 Yushu earthquake, we aim to provide useful medical information for the rational application and allocation of medical resources and better implementation of medical relief in earthquake-stricken areas.Patients...http://www.medconnect.com.my/tabid/100/ct9/c454544/Orthopaedic-injury-analysis-in-the-2010-Yushu-China-Earthquake/Default.aspx01-Jun-2012Abstract: There is little information available about the epidemiology of open fractures. We examined 2386 open fractures over a 15-year period analysing the incidence and severity of the fractures. The majority of open fractures are low energy injuries with only 22.3% of open fractures being...http://www.medconnect.com.my/tabid/100/ct9/c454545/The-epidemiology-of-open-fractures-in-adults-A-15-year-review/Default.aspx01-Jun-2012Abstract: The use of open wedge high tibial osteotomy (HTO) to correct varus deformity of the knee is well established. However, the stability of the various implants used in this procedure has not been previously demonstrated. In this study, the two most common types of plates were analysed (1)...http://www.medconnect.com.my/tabid/100/ct9/c454548/Finite-element-analysis-of-Puddu-and-Tomofix-plate-fixation/Default.aspx01-Jun-2012Abstract: The aim of this experimental cadaver study was to investigate which kinds of lesions could occur in jam events between the glass and seal entry of power-operated motor vehicle side door windows at two different closing forces.Ten hands of fresh cadaver specimens were used. Three different...http://www.medconnect.com.my/tabid/100/ct9/c454550/Finger-injuries-caused-by-power-operated-windows-of-motor-vehicles-/Default.aspx01-Jun-2012Abstract: Purpose: To establish the intra-operative radiographic parameters that predict the need for percutaneous wire fixation to prevent redisplacement following manipulation for displaced paediatric distal radius fractures.Materials and methods: A retrospective study of 105 children, assessing...http://www.medconnect.com.my/tabid/100/ct9/c454553/Displaced-paediatric-distal-radius-fractures-When-should-we-use-percutaneous-wires-/Default.aspx01-Jun-2012Abstract: Introduction: Long-term follow-up studies focusing on the posterior extensor muscles in patients suffering from whiplash injury are scarce. The purpose of this study was to elucidate the changes in the posterior extensor muscles 10years after whiplash injury.Methods: Twenty-three patients...http://www.medconnect.com.my/tabid/100/ct9/c454556/Cross-sectional-area-of-the-posterior-extensor-muscles-of-the/Default.aspx01-Jun-2012Abstract: Purpose: The effects of cerclage wiring in the open reduction and internal fixation of displaced associated anterior column and posterior hemi-transverse acetabular fractures were evaluated.Methods: This is a retrospectively clinical study of such cases where the main surgical strategy...http://www.medconnect.com.my/tabid/100/ct9/c454558/Cerclage-wiring-in-displaced-associated-anterior-column-and-posterior-hemi-transverse/Default.aspx01-Jun-2012Abstract: Introduction: During plate fixation of clavicular fractures the brachial plexus and subclavian vessels are vulnerable to injury beneath the clavicle. Locking plate fixation allows for mono-cortical fixation, theoretically reducing the risk of injury to these structures. Biomechanical...http://www.medconnect.com.my/tabid/100/ct9/c454560/Biomechanical-analysis-of-locked-and-non-locked-plate-fixation-of-the-clavicle/Default.aspx01-Jun-2012Summary: Purpose: The aim of the study was to examine triangular fibrocartilage (TFCC) injury patterns associated with unstable, extra-articular dorsally displaced distal radius fractures.Methods: Twenty adult patients with an Arbeitsgemeinschaft für Osteosynthesefragen (AO), type A2 or A3, distal...http://www.medconnect.com.my/tabid/100/ct9/c454564/Patterns-of-triangular-fibrocartilage-complex-TFCC-injury-associated-with/Default.aspx01-Jun-2012Abstract: Introduction: Scaphoid fractures with displacement have a higher incidence of nonunion that can cause pain and reduced movement, strength and function. The aim of this study was to review the evidence available and establish the risk of nonunion associated with management of displaced...http://www.medconnect.com.my/tabid/100/ct9/c454566/Management-of-displaced-fractures-of-the-waist-of-the/Default.aspx01-Jun-2012Abstract: Background: Plate and screw fixation was introduced for complex fractures of the hand. Several risk factors for a poor functional outcome have been identified, but there is a paucity of evidence regarding predictors of finger stiffness in difficult hand fractures. The purpose of this...http://www.medconnect.com.my/tabid/100/ct9/c454569/Predictors-of-the-postoperative-range-of-finger-motion-for/Default.aspx01-Jun-2012Abstract: This study from the Swedish Hip Arthroplasty Register (SHAR) compares cemented (Thompson®, Exeter Trauma Stem (ETS)®) and uncemented (Austin-Moore®) monoblock hemiarthroplasties (n=1116 and 616, respectively) with modular ones (n=18,659).Austin-Moore® prostheses lead to more re-operations...http://www.medconnect.com.my/tabid/100/ct9/c454571/Monoblock-hemiarthroplasties-for-femoral-neck-fractures-A-part/Default.aspx01-Jun-2012Abstract: Introduction: Drilling is an integral part of almost all boney operations. Various anatomical structures coursing close to the bone are at risk if the drill bit projects beyond the far cortex. Aim of this study was to evaluate and quantify the depth to which surgeons over drill beyond the...http://www.medconnect.com.my/tabid/100/ct9/c454574/Drilling-not-a-benign-procedure-Laboratory-simulation-of-true-drilling-depth/Default.aspx01-Jun-2012Abstract: Background and purpose: Autogenous bone grafts from the iliac crest are frequently harvested for autologous bone transplantation, because this is still the gold standard in the treatment of many bone defects. However, significant donor site morbidity must be considered. We have developed...http://www.medconnect.com.my/tabid/100/ct9/c454575/Donor-site-reconstruction-in-iliac-crest-tricortical-bone-graft-Surgical-technique/Default.aspx01-Jun-2012Abstract: The standard management of degloving injuries involves either immediate grafting with the avulsed skin or full- or split-thickness grafts at a later date. Alternative methods include pedicle and free flaps and revascularisation. The authors present an innovative technique of treating...http://www.medconnect.com.my/tabid/100/ct9/c454578/Vacuum-assisted-closure-dermal-regeneration-template-and-degloved-cryopreserved-skin/Default.aspx01-Jun-2012Using a correctly sized implant when internally fixing of fractures is crucial. Too long an implant may not fit and too short may compromise the strength and the stability of the fracture fixation. The mandatory introduction of presterilised and prepacked implants in sealed packages in the UK...http://www.medconnect.com.my/tabid/100/ct9/c454580/A-simple-way-to-determine-appropriate-implant-size-when-fixing-fractures/Default.aspx01-Jun-2012Intertrochanteric fractures are very common fractures that occur in the elderly, owing to the fragile nature of their skeleton and are related to their propensity to falls. They are extra-articular fractures of the hip that occur between the extracapsular region of the femoral neck and just distal...http://www.medconnect.com.my/tabid/100/ct9/c454583/Intramedullary-nailing-of-trochanteric-fractures-Operative-technical-tips/Default.aspx01-Jun-2012Abstract: Background: Combining closed reduction techniques with minimally invasive plate osteosynthesis (MIPO) or intramedullary nailing is a technically challenging procedure, especially when dealing with complex femoral fractures such as periprosthetic fractures. Cerclage wiring is a well known...http://www.medconnect.com.my/tabid/100/ct9/c454585/Percutaneous-cerclage-wiring-for-reduction-of-periprosthetic-and-difficult/Default.aspx01-Jun-2012 Background: Previous efforts to forecast future trends in obesity applied linear forecasts assuming that the rise in obesity would continue unabated. However, evidence suggests that obesity prevalence may be leveling off. Purpose: This study presents estimates of adult obesity and severe...http://www.medconnect.com.my/tabid/100/ct9/c460172/Obesity-and-Severe-Obesity-Forecasts-Through-2030/Default.aspx01-Jun-2012 Background: Limited evidence exists on the metabolic and cardiovascular risk correlates of commuting by vehicle, a habitual form of sedentary behavior. Purpose: To examine the association between commuting distance, physical activity, cardiorespiratory fitness (CRF), and metabolic risk...http://www.medconnect.com.my/tabid/100/ct9/c460173/Commuting-Distance-Cardiorespiratory-Fitness-and-Metabolic-Risk/Default.aspx01-Jun-2012 Background: Little is known about the influence of in-town fast-food availability on family-level fast-food intake in nonmetropolitan areas. Purpose: The purpose of the current study was to determine whether the presence of chain fast-food outlets was associated with fast-food intake among...http://www.medconnect.com.my/tabid/100/ct9/c460174/Fast-Food-Environments-and-Family-Fast-Food-Intake-in-Nonmetropolitan-Areas/Default.aspx01-Jun-2012 Background: Although most Medicaid programs have some coverage for tobacco-cessation treatments, little is known about how well the covered treatments are utilized among Medicaid enrollees. Purpose: To examine the impact of Arkansas Medicaid coverage of tobacco-cessation treatment on...http://www.medconnect.com.my/tabid/100/ct9/c460175/Medicaid-Coverage-and-Utilization-of-Covered-Tobacco-Cessation-Treatments-The/Default.aspx01-Jun-2012 Background: The Affordable Care Act mandates that new insurance plans cover smoking-cessation therapy without cost-sharing. Previous cost difference estimates, which show a spike around the time of cessation, suggest premiums might rise as a result of covering these services. Purpose: The goal...http://www.medconnect.com.my/tabid/100/ct9/c460176/Healthcare-Costs-Around-the-Time-of-Smoking-Cessation/Default.aspx01-Jun-2012 Background: An increase in total vaccine exemptions (medical, philosophic, and religious) occurred in Arkansas after a 2003 legislation added a philosophic category and used a new process for vaccine exemptions. By legislative requirement, the Arkansas Department of Health monitored exemptions...http://www.medconnect.com.my/tabid/100/ct9/c460177/Vaccine-Policy-and-Arkansas-Childhood-Immunization-Exemptions-A-Multi-Year-Review/Default.aspx01-Jun-2012 Background: Disparities in receipt of preventive services by people with mental illness have been documented previously. However, whether these disparities extend to screening mammography among individuals experiencing comparable barriers to accessing care has not been examined fully. Purpose:...http://www.medconnect.com.my/tabid/100/ct9/c460178/Mental-Illness-and-Use-of-Screening-Mammography-Among-Medicaid-Beneficiaries/Default.aspx01-Jun-2012 Background: To successfully stimulate cycling, it is necessary to understand the factors that facilitate or inhibit cycling. Little is known about how changes in the neighborhood environment are related to changes in cycling behavior. Purpose: This study aimed to identify environmental...http://www.medconnect.com.my/tabid/100/ct9/c460179/Taking-Up-Cycling-After-Residential-Relocation-Built-Environment-Factors/Default.aspx01-Jun-2012 Background: Parks are an important setting for leisure-time physical activity. Understanding how to attract residents to parks and encourage park users to be physically active is an important public health initiative. Natural experiments are a research priority for investigating whether changes...http://www.medconnect.com.my/tabid/100/ct9/c460180/Park-Improvements-and-Park-Activity-A-Natural-Experiment/Default.aspx01-Jun-2012 Background: Stress fractures and other musculoskeletal injuries are major sources of morbidity among female military trainees. Several risk factors have been postulated, particularly pre-existing fitness, usually assessed with post-entry run time for ≥1.0 mile. Purpose: Physical fitness is not...http://www.medconnect.com.my/tabid/100/ct9/c460182/Step-Test-Performance-and-Risk-of-Stress-Fractures-Among-Female-Army-Trainees/Default.aspx01-Jun-2012 Background: Binge drinking (≥4 drinks for women; ≥5 drinks for men, per occasion) is responsible for more than half of the estimated 80,000 U.S. deaths annually and three-quarters of the $223.5 billion in costs in 2006. Binge drinking prevalence is assessed more commonly than binge drinking...http://www.medconnect.com.my/tabid/100/ct9/c460185/Binge-Drinking-Intensity-A-Comparison-of-Two-Measures/Default.aspx01-Jun-2012 Context: Video games represent a multibillion-dollar industry in the U.S. Although video gaming has been associated with many negative health consequences, it also may be useful for therapeutic purposes. The goal of this study was to determine whether video games may be useful in improving health...http://www.medconnect.com.my/tabid/100/ct9/c460187/Role-of-Video-Games-in-Improving-Health-Related-Outcomes-A-Systematic-Review/Default.aspx01-Jun-2012Abstract: The term P4 medicine is used to denote an evolving field of medicine that uses systems biology approaches and information technologies to enhance wellness rather than just treat disease. Its four components include predictive, preventive, personalized, and participatory medicine. In the...http://www.medconnect.com.my/tabid/100/ct9/c460190/A-Population-Approach-to-Precision-Medicine/Default.aspx01-Jun-2012Abstract: Over-reliance on decontextualized, standardized implementation of efficacy evidence has contributed to slow integration of evidence-based interventions into health policy and practice. This article describes an “evidence integration triangle” (EIT) to guide translation, implementation,...http://www.medconnect.com.my/tabid/100/ct9/c460192/An-Evidence-Integration-Triangle-for-Aligning-Science-with-Policy-and-Practice/Default.aspx01-Jun-2012 Context: Approximately 22% of U.S. young adults (aged 18–24 years) are smokers. Young adults typically display an interest in quitting, but it is unknown whether the evidence-based cessation programs designed for adults will be equally effective for young adults. This meta-analysis investigated...http://www.medconnect.com.my/tabid/100/ct9/c460195/Efficacy-of-Smoking-Cessation-Interventions-for-Young-Adults-A-Meta-Analysis/Default.aspx01-Jun-2012The current newborn screening program for sickle cell disease in Jamaica started in 1995 and encompasses three main hospitals on the island, which are responsible for ∼43% of births islandwide. Our paper titled “Newborn Sickle Cell Disease Screening: the Jamaican Experience (1995–2000)” was...http://www.medconnect.com.my/tabid/100/ct9/c460197/Newborn-Screening-in-Jamaica-Inaccurate-Reference/Default.aspx01-Jun-2012We welcome the opportunity to provide additional support for the assertion in our paper on sickle cell disease (SCD) in Africa that newborn screening can result in substantially reduced mortality even in the absence of specific interventions such as penicillin prophylaxis or pneumococcal conjugate...http://www.medconnect.com.my/tabid/100/ct9/c460200/The-Jamaican-Historical-Experience-of-the-Impact-of-Educational/Default.aspx01-Jun-2012Two very different books by leaders in the field of preventive medicine have been recently published. In one, Faust and Menzel have edited entries from more than a dozen contributors addressing the economic, efficacy, and ethical issues around preventive care versus medical treatment. In the other,...http://www.medconnect.com.my/tabid/100/ct9/c460202/Prevention-vs-Treatment-Whats-the-Right-Balance-/Default.aspx01-Jun-2012Summary: Differences in pain perception between athletes and nonathletes were meta-analyzed. Available data suggest that regular physical activity is associated with specific alterations in pain perception.Abstract: This study systematically reviewed differences in pain perception between athletes...http://www.medconnect.com.my/tabid/100/ct9/c460496/Pain-perception-in-athletes-compared-to-normally-active-controls-A/Default.aspx01-Jun-2012Abstract: Background: Carers for people with dementia experience high levels of anxiety and depression. Coping style has been associated with carer anxiety and depression.Method: We systematically reviewed studies examining the relationships between coping and anxiety or depression among carers of...http://www.medconnect.com.my/tabid/100/ct9/c449362/Coping-strategies-and-psychological-morbidity-in-family-carers-of/Default.aspx01-Jun-2012Abstract: Background: The purpose of this work was to study the association between the PON1 L55M and Q192R polymorphisms and bipolar I disorder in Tunisian patients and to explore their relation to the sociodemographic, clinical and therapeutic characteristics of this disease.Patients and methods:...http://www.medconnect.com.my/tabid/100/ct9/c449363/Association-between-bipolar-I-disorder-and-the-L55M-and/Default.aspx01-Jun-2012Abstract: Background: The aim of this study was to investigate the characteristics of affective temperaments in general non-clinical population in different countriesMethod: We performed a detailed search of published studies (one unpublished) investigating affective temperaments in non-clinical...http://www.medconnect.com.my/tabid/100/ct9/c449364/Affective-temperaments-in-general-population-A-review-and-combined/Default.aspx01-Jun-2012Abstract: Background: Few studies have explored the evolution of perinatal depressive symptoms (PNDS) throughout the perinatal period.Aims: To evaluate in a low-risk sample, whether different evolutive profiles of PNDS exist from pregnancy to 2-years postpartum, and whether the subgroups differ...http://www.medconnect.com.my/tabid/100/ct9/c449365/Evolution-of-perinatal-depressive-symptoms-from-pregnancy-to-two/Default.aspx01-Jun-2012Abstract: Background: Jackson's (2005, 2008a) hybrid model of learning identifies a number of learning mechanisms that lead to the emergence and maintenance of the balance between rationality and irrationality. We test a general hypothesis that Jackson's model will predict depressive symptoms, such...http://www.medconnect.com.my/tabid/100/ct9/c449366/Mechanisms-underlying-REBT-in-mood-disordered-patients-Predicting-depression/Default.aspx01-Jun-2012Abstract: Background: Relationships among religiosity and other psychosocial factors in determining suicidal behaviors in adolescence and in emerging adulthood have been inconclusive. We sought to investigate prospective relationships among religiosity, psychosocial factors and suicidal behaviors...http://www.medconnect.com.my/tabid/100/ct9/c449367/A-longitudinal-evaluation-of-religiosity-and-psychosocial-determinants-of/Default.aspx01-Jun-2012Abstract: Background: The purpose of this study was to examine how sex differences in suicide rates unfolded in a long-term follow up of patients who had been diagnosed with major depression.Method: Patients who were diagnosed with major depression in the Chichester/Salisbury Catchment Area Study...http://www.medconnect.com.my/tabid/100/ct9/c449368/Long-term-follow-up-of-suicide-in-a-clinically-depressed-community-sample/Default.aspx01-Jun-2012Abstract: Background: Abnormalities have been identified in the Cognitive Control Network (CCN) and the Default Mode Network (DMN) during episodes of late-life depression. This study examined whether functional connectivity at rest (FC) within these networks characterizes late-life depression and...http://www.medconnect.com.my/tabid/100/ct9/c449369/Functional-connectivity-in-the-cognitive-control-network-and-the-default/Default.aspx01-Jun-2012Abstract: Background: Sleep problems are commonly associated with the primary diagnostic criteria for many psychiatric disorders. Evidence suggests sleep disturbances may precede development of psychiatric disorders and the severity of psychopathology reflects the severity of sleep problems....http://www.medconnect.com.my/tabid/100/ct9/c449370/Peeking-into-the-minds-of-troubled-adolescents-The-utility/Default.aspx01-Jun-2012Abstract: Background: Invariant item ordering (IIO) is defined as the extent to which items have the same ordering (in terms of item difficulty/severity — i.e. demonstrating whether items are difficult [rare] or less difficult [common]) for each respondent who completes a scale. IIO is therefore...http://www.medconnect.com.my/tabid/100/ct9/c449371/A-hierarchy-of-distress-and-invariant-item-ordering-in/Default.aspx01-Jun-2012Abstract: Background: The efficacy and tolerability of antidepressants (ADs) to treat or avoid episodes of depression in bipolar disorder (BPD) patients as well as reasons for using them remain unresolved.Methods: We analyzed patient-characteristics and outcomes of episodes of acute major...http://www.medconnect.com.my/tabid/100/ct9/c449372/Bipolar-depression-Clinical-correlates-of-receiving-antidepressants/Default.aspx01-Jun-2012Abstract: Background: The role of stigma in help-seeking for depression is unclear. We hypothesize that in persons experiencing symptoms of depression, personal stigmatizing attitudes impair appraisal of the present condition as mental health problem and thus reduce the perceived need for...http://www.medconnect.com.my/tabid/100/ct9/c449373/Personal-stigma-problem-appraisal-and-perceived-need-for-professional/Default.aspx01-Jun-2012Abstract: Objectives: The current study investigated whether a single brief cognitive assessment, processing speed, could be considered as a valid endophenotype for bipolar disorder (BD).Methods: Processing speed was assessed using the Digit Symbol Test (DST) in 53 euthymic BD probands (BD-P), 50...http://www.medconnect.com.my/tabid/100/ct9/c449374/Is-processing-speed-a-valid-cognitive-endophenotype-for-bipolar-disorder-/Default.aspx01-Jun-2012Harold Fox, the co-founder of Placenta along with Page Faulk, died on 21st March 2012. An obituary written by his Mancunian colleagues appears elsewhere in this issue. In that piece, Robert Boyd and Carolyn Jones state that ‘he is one to whom current students of the placenta owe a substantial debt...http://www.medconnect.com.my/tabid/100/ct9/c452393/To-Harold-Fox-Our-thanks/Default.aspx01-Jun-2012Harold Fox, MD (Gold Medal) FRC Path FRCOG, died suddenly at home on 21st March 2012, aged 80 years. His contribution to our understanding of the placenta cannot be overestimated.http://www.medconnect.com.my/tabid/100/ct9/c452412/Harold-Fox-1931-2012/Default.aspx01-Jun-2012The scope of minimally invasive laparoscopic and robotic techniques for urological surgery has expanded vastly during the last decade. These techniques hold the promise of applying modern surgical technology to decrease patient morbidity and improve surgical outcomes. Application of minimally...http://www.medconnect.com.my/tabid/100/ct9/c454920/Learning-From-Our-Patients-Complications-and-the-Future-of/Default.aspx01-Jun-2012Posttraumatic stress disorder (PTSD) is a common, distressing, and debilitating consequence of the experience of extremely stressful life events, exemplified by combat, sexual assault, torture, or natural disasters. Although the majority of people exposed to these extreme events recover within days...http://www.medconnect.com.my/tabid/100/ct9/c455830/Enhancing-Prolonged-Exposure-Therapy-for-Posttraumatic-Stress-Disorder-with/Default.aspx01-Jun-2012The history of the field of biological psychiatry can be cynically encapsulated by the quest to reverse engineer serendipitous clinical findings. The role of monoamines in depression, dopamine in schizophrenia, and second messengers in bipolar disorder have all been reversed engineered from...http://www.medconnect.com.my/tabid/100/ct9/c455831/Translating-the-Rosetta-Stone-of-N-Acetylcysteine/Default.aspx01-Jun-2012Despite decades of intense research and development, current treatments for schizophrenia (SZ) have not only met with limited efficacy but are also often associated with serious side effects, justifying the heightened interest in the development of alternate therapies (). With mounting experimental...http://www.medconnect.com.my/tabid/100/ct9/c455832/N-Acetylcysteine-for-the-Treatment-of-Glutathione-Deficiency-and-Oxidative/Default.aspx01-Jun-2012Three very different methods are currently used to repair acute retinal detachments. Elsewhere in this issue of the Journal, Hwang reviews data obtained from Medicare part B summaries, finding regional differences in the choice of procedure for repair of retinal detachment. The author gives us an...http://www.medconnect.com.my/tabid/100/ct9/c459529/How-We-Currently-Choose-to-Repair-Retinal-Detachment-in/Default.aspx01-Jun-2012Carl Koller (1837-1944) became known in Vienna at the age of 26 when he first appreciated the usefulness of cocaine as a local anesthetic in ophthalmology. He nonetheless decided that his professional opportunities were limited in Vienna, a decision probably influenced by his wounding of a fellow...http://www.medconnect.com.my/tabid/100/ct9/c459557/AJO-History-of-Ophthalmology-Series-Carl-Koller-in-New-York-City/Default.aspx01-Jun-2012Frédéric Cochennec, Isabelle Javerliat, Isabelle Di Centa, Olivier Goëau-Brissonnière, Marc Coggia Objective: The feasibility of total laparoscopic abdominal aortic aneurysm (AAA) repair has been well established. In a previous case-control study, we showed that the postoperative courses of total...http://www.medconnect.com.my/tabid/100/ct9/c459754/Selected-Abstracts-from-the-June-Issue-of-the-Journal-of-Vascular-Surgery/Default.aspx01-Jun-2012Abstract: Total knee arthroplasty (TKA) can lead to substantial blood loss. To avoid the high costs of autologous blood predonation programs and efficiently allocate limited blood resources, we sought to identify preoperative and intraoperative factors associated with allogeneic blood transfusion...http://www.medconnect.com.my/tabid/100/ct9/c460605/Predicting-Need-for-Allogeneic-Transfusion-After-Total-Knee-Arthroplasty/Default.aspx01-Jun-2012Background: Superior labrum anterior-posterior (SLAP) lesions of the shoulder that require surgical repair are relatively uncommon. However, recent observations suggest that there may be a rise in the incidence of SLAP lesion repair.Materials and methods: The Statewide Planning and Research...http://www.medconnect.com.my/tabid/100/ct9/c460946/The-rising-incidence-of-arthroscopic-superior-labrum-anterior-and/Default.aspx01-Jun-2012An advisory committee of the US Food and Drug Administration (FDA) has recommended approval of combined tenofovir-emtricitabine for HIV-1 pre-exposure prophylaxis (PrEP) in high-risk populations, including for serodiscordant couples and men who have sex with men. A final decision from the FDA is...http://www.medconnect.com.my/tabid/100/ct9/c459365/-This-Week-in-Medicine-May-19-25-2012/Default.aspx19-May-2012The world's population is ageing owing to increasing life expectancy and declining fertility. The populations of low-income and middle-income countries are now joining those of high-income countries in facing an increasing burden of chronic diseases. A report, Shades of gray: a cross-country study...http://www.medconnect.com.my/tabid/100/ct9/c459366/-Editorial-Chronic-disease-management-in-ageing-populations/Default.aspx19-May-2012In May, 2002, under the auspices of its Advisory Committee on Health Research, WHO released Genomics and World Health, a report that assessed genomics research and its future possibilities. The report addressed issues of equitable sharing of benefits between low-income and high-income countries,...http://www.medconnect.com.my/tabid/100/ct9/c459367/-Comment-Genomics-and-world-health-a-decade-on/Default.aspx19-May-2012Development of new therapeutics for adults with metastatic soft-tissue sarcoma has been frustratingly slow, with few effective drugs identified in the past 30 years. Despite their common mesenchymal origin, soft-tissue sarcomas are heterogeneous and increasing knowledge of their molecular biology...http://www.medconnect.com.my/tabid/100/ct9/c459368/-Comment-Pazopanib-and-the-treatment-palette-for-soft-tissue-sarcoma/Default.aspx19-May-2012In The Lancet, findings from Surya Biere and colleagues' multicentre randomised trial comparing minimally invasive oesophagectomy with open oesophagectomy provide evidence for short-term benefits of the minimally invasive technique for patients with resectable oesophageal cancer. Seven (12%) of 59...http://www.medconnect.com.my/tabid/100/ct9/c459370/-Comment-Is-minimally-invasive-preferable-to-open-oesophagectomy-/Default.aspx19-May-2012In The Lancet, Gerald Falchook and colleagues present results from a phase 1 trial of dabrafenib in patients with incurable solid tumours. In an expansion cohort, patients with BRAF-mutant tumours (including those with non-Val600Glu mutations) from three populations were treated at the recommended...http://www.medconnect.com.my/tabid/100/ct9/c459372/-Comment-Extending-the-reach-of-BRAF-targeted-cancer-therapy/Default.aspx19-May-2012The NCD Alliance aims to put non-communicable diseases (NCDs) on the global agenda to address the NCD crisis. Improving outcomes in morbidity and mortality by 2015 will clearly depend to a large extent on tackling the burden of NCDs, especially in developing countries.http://www.medconnect.com.my/tabid/100/ct9/c459375/-Comment-Tackling-NCDs-a-different-approach-is-needed/Default.aspx19-May-2012Until May 8, Canada was the only member of the G8 without a national mental health strategy. However, the Mental Health Commission of Canada has remedied this shortcoming, releasing the first-ever national mental health strategy, entitled Changing Directions, Changing Lives.http://www.medconnect.com.my/tabid/100/ct9/c459377/-Editorial-A-first-for-mental-health-in-Canada/Default.aspx19-May-2012To say that India's drug regulatory authority, the Central Drugs Standard Control Organisation (CDSCO)—whose remit includes new drug approval, licensing of manufacturing facilities, and regulation of drug trials—is not fit for purpose seems a gross understatement. A damning 118-page report from the...http://www.medconnect.com.my/tabid/100/ct9/c459380/-Editorial-Drug-regulation-in-India-the-time-is-ripe-for-change/Default.aspx19-May-2012Sitting over lunch with a scientist who serves on the governing body of a well-known UK research funder, together with the former Dean of a British medical school (and now one his university's senior administrators), the conversation turned to the Francis Crick Institute. The “Crick” is expected to...http://www.medconnect.com.my/tabid/100/ct9/c459382/-Comment-Offline-Celebrating-the-Francis-Crick-Institute-with-questions/Default.aspx19-May-2012With a perfect storm of patent expirations, poor development pipelines, and pressures on drug pricing, is the party over for an industry once considered recession-proof? David Holmes reports.http://www.medconnect.com.my/tabid/100/ct9/c459384/-World-Report-Skies-darken-over-drug-companies/Default.aspx19-May-2012A 2005 US Institute of Medicine report championed care plans for people who survive cancer. But, as Bob Kirsch reports, many survivors are still missing out on the close follow-up that they need.http://www.medconnect.com.my/tabid/100/ct9/c459387/-World-Report-Many-US-cancer-survivors-still-lost-in-transition/Default.aspx19-May-2012The Universe is filled with a mysterious essence, the ether, through which light is transmitted. Life is imbued with an equally enigmatic principle, the “vital force”. Some materials—like lead and gold—can be heated up and will return to their original state when cold, but others like chickens or...http://www.medconnect.com.my/tabid/100/ct9/c459389/-Perspectives-The-power-of-belonging/Default.aspx19-May-2012“Girl, 12, Killed by Drunk Driver While Trick-or-Treating.” This headline appeared in the Nov 1, 2011, online edition of the Daily Mail, a UK newspaper. However, the unfortunate victim, Faith Monet Love, was killed in Las Vegas, Nevada, where she lived and was collecting Halloween candy with her...http://www.medconnect.com.my/tabid/100/ct9/c459391/-Perspectives-Drunk-driving-across-the-globe-lets-learn-from-one-another/Default.aspx19-May-2012Our paper on priority actions for the non-communicable disease (NCD) crisis proposed five actions to prevent and treat NCDs: international and national political leadership, prevention, treatment, international co-operation, and accountability and monitoring. These actions are relevant for all...http://www.medconnect.com.my/tabid/100/ct9/c459393/-Correspondence-Tackling-NCDs-a-different-approach-is-needed/Default.aspx19-May-2012In their Seminar on low back pain, Federico Balagué and colleagues (Feb 4, p 482) conclude that (occupational) mechanical factors are unlikely to be independently causative of low back pain. This far-reaching conclusion is based on reviews of published epidemiological studies and on the relation...http://www.medconnect.com.my/tabid/100/ct9/c459397/-Correspondence-Non-specific-low-back-pain/Default.aspx19-May-2012In the BALTI-2 trial, Fang Gao Smith and colleagues (Jan 21, p 229) report an increase in 28-day mortality after a 7-day infusion of salbutamol compared with placebo in patients with early acute respiratory distress syndrome (ARDS). Major discrepancies between predicted and observed mortality make...http://www.medconnect.com.my/tabid/100/ct9/c459399/-Correspondence-Intravenous-salbutamol-in-ARDS-and-increased-mortality/Default.aspx19-May-2012I am writing to correct Sheldon Krimsky's presumption in his Art of Medicine essay (Jan 14, p 114) that BiDil (hydralazine hydrochloride plus isosorbide dinitrate) is no longer available.http://www.medconnect.com.my/tabid/100/ct9/c459401/-Correspondence-BiDil-alive-and-kicking/Default.aspx19-May-2012There is growing support for making research data widely available to accelerate the pace of scientific discovery, foster cross-sectoral collaboration, and ultimately enhance the translation of science to clinical and public health practice. We would like to draw attention to an additional, less...http://www.medconnect.com.my/tabid/100/ct9/c459403/-Correspondence-Educating-for-the-future-another-important-benefit-of-data-sharing/Default.aspx19-May-2012A catastrophic breakdown in regulatory functions in Pakistan has caused more than 120 deaths. The case highlights the need for urgent attention to WHO's core functions such as those supporting the safety of medicines. We describe what occurred and its relation to the WHO reforms.http://www.medconnect.com.my/tabid/100/ct9/c459405/-Correspondence-Urgent-need-for-WHOs-reform-to-prioritise-core-functions/Default.aspx19-May-2012In recent years, Chinese hospitals have seen numerous violent incidents perpetrated by patients on medical staff. On March 23, an intern of the First Affiliated Hospital of Harbin Medical University, Wang Hao, was killed by an angry patient wielding a fruit knife. Many doctors and medical students...http://www.medconnect.com.my/tabid/100/ct9/c459407/-Correspondence-New-generations-of-Chinese-doctors-face-crisis/Default.aspx19-May-2012Ed Holt's World Report on the redrafting of Romania's health-care law (Feb 11, p 505) emphasises one of the most sensitive issues of the Romanian health-care system: informal payments. Although most Romanians will have offered an informal payment at least once when interacting with health...http://www.medconnect.com.my/tabid/100/ct9/c459409/-Correspondence-The-saga-of-the-Romanian-health-care-reform/Default.aspx19-May-2012José Baddini Martinez and Adriana Ignacio de Padua (Feb 4, p e32) raise an important issue regarding over-reliance on modern technology for the identification and diagnosis of pathology. Their reference to the Star Trek character Dr Leonard McCoy and his ever-reliable tricorder cleverly illustrates...http://www.medconnect.com.my/tabid/100/ct9/c459411/-Correspondence-The-real-McCoy-/Default.aspx19-May-2012Pazopanib is a new treatment option for patients with metastatic non-adipocytic soft-tissue sarcoma after previous chemotherapy.http://www.medconnect.com.my/tabid/100/ct9/c459413/-Articles-Pazopanib-for-metastatic-soft-tissue-sarcoma-PALETTE-a-randomised-/Default.aspx19-May-2012These findings provide evidence for the short-term benefits of minimally invasive oesophagectomy for patients with resectable oesophageal cancer.http://www.medconnect.com.my/tabid/100/ct9/c459415/-Articles-Minimally-invasive-versus-open-oesophagectomy-for-patients-with/Default.aspx19-May-2012Dabrafenib is safe in patients with solid tumours, and an active inhibitor of Val600-mutant BRAF with responses noted in patients with melanoma, brain metastases, and other solid tumours.http://www.medconnect.com.my/tabid/100/ct9/c459417/-Articles-Dabrafenib-in-patients-with-melanoma-untreated-brain-metastases-/Default.aspx19-May-2012Tuberculosis is still one of the most important causes of death worldwide. The 2010 Lancet tuberculosis series provided a comprehensive overview of global control efforts and challenges. In this update we review recent progress. With improved control efforts, the world and most regions are on track...http://www.medconnect.com.my/tabid/100/ct9/c459419/-Review-Scaling-up-interventions-to-achieve-global-tuberculosis-control-/Default.aspx19-May-2012Thomas Wakley—founding editor of The Lancet, member of Parliament, coroner and, for 12 years, all three simultaneously—died 150 years ago. His fullest biography is more than a century old, but still provides a good account of the struggles and achievements of this extraordinary yet at times rather...http://www.medconnect.com.my/tabid/100/ct9/c459421/-Review-Thomas-Wakley-1795-1862-a-biographical-sketch/Default.aspx19-May-2012A 65-year-old man was referred by his general practitioner for an ECG at our hospital after a single episode of syncope occurring at rest. He had felt light-headed immediately before collapsing but had had no other symptoms. The ECG showed sinus rhythm at 68 beats per min, with striking...http://www.medconnect.com.my/tabid/100/ct9/c459423/-Case-Report-A-heart-without-hormones/Default.aspx19-May-2012 Purpose Because insurers use performance and quality metrics to inform reimbursement, identifying remediable causes of poor-quality cancer care is imperative. We undertook this descriptive cohort study to assess key predictors of women's perceived quality of their breast cancer care and actual...http://www.medconnect.com.my/tabid/100/ct9/c460086/Quality-of-Breast-Cancer-Care-Perception-Versus-Practice-Health/Default.aspx19-May-2012 Purpose Prolonged and disabling fatigue is prevalent after cancer treatment, but the early natural history of cancer-related fatigue (CRF) has not been systematically examined to document consistent presence of symptoms. Hence, relationships to cancer, surgery, and adjuvant therapy are...http://www.medconnect.com.my/tabid/100/ct9/c460089/Cancer-Related-Fatigue-in-Women-With-Breast-Cancer-Outcomes-of/Default.aspx19-May-2012 Purpose Non–small-cell lung cancer (NSCLC) is predominantly a disease of the elderly. Retrospective analyses of the National Cancer Institute of Canada Clinical Trials Group JBR.10 trial and the Lung Adjuvant Cisplatin Evaluation (LACE) meta-analysis suggest that the elderly benefit from...http://www.medconnect.com.my/tabid/100/ct9/c460090/Adjuvant-Chemotherapy-for-Non-Small-Cell-Lung-Cancer-in-the-Elderly-/Default.aspx19-May-2012 Purpose To conduct a phase I dose-escalation trial assessing safety and response of recombinant immunotoxin moxetumomab pasudotox (CAT-8015, HA22) in chemotherapy-resistant hairy cell leukemia (HCL). Patients and Methods Eligible patients had relapsed/refractory HCL after ≥ two prior therapies...http://www.medconnect.com.my/tabid/100/ct9/c460093/Phase-I-Trial-of-Anti-CD22-Recombinant-Immunotoxin-Moxetumomab-Pasudotox-CAT-8015/Default.aspx19-May-2012 Purpose Objective factors for making choices about the treatment of elderly patients with cancer are lacking. This investigation aimed to help physicians select appropriate treatments through the identification of factors that predict early death (< 6 months) after initiation of chemotherapy...http://www.medconnect.com.my/tabid/100/ct9/c460095/Predictors-of-Early-Death-Risk-in-Older-Patients-Treated-With/Default.aspx19-May-2012 Purpose To analyze the prognostic relevance of circulating T cells responding to NY-ESO-1, Melan-A, MAGE-3, and survivin in patients with melanoma with distant metastasis. Patients and Methods We examined 84 patients with follow-up after analysis (cohort A), 18 long-term survivors with an...http://www.medconnect.com.my/tabid/100/ct9/c460100/Functional-T-Cells-Targeting-NY-ESO-1-or-Melan-A-Are-Predictive/Default.aspx19-May-2012 Purpose The primary objective of Children's Oncology Group study P9641 was to demonstrate that surgery alone would achieve 3-year overall survival (OS) ≥ 95% for patients with asymptomatic International Neuroblastoma Staging System stages 2a and 2b neuroblastoma (NBL). Secondary objectives...http://www.medconnect.com.my/tabid/100/ct9/c460103/Outcome-After-Surgery-Alone-or-With-Restricted-Use-of/Default.aspx19-May-2012 Purpose Ganitumab is a fully human monoclonal antibody against type-1 insulin-like growth factor receptor (IGF1R). An open-label phase II study was conducted to evaluate the efficacy and safety of ganitumab monotherapy in patients with metastatic Ewing family tumors (EFT) or desmoplastic small...http://www.medconnect.com.my/tabid/100/ct9/c460106/Phase-II-Study-of-Ganitumab-a-Fully-Human-Anti-Type-1/Default.aspx19-May-2012 Purpose To validate the interval to biochemical failure (IBF) as a prognostic factor at the time of biochemical failure for prostate cancer mortality (PCM) following radiotherapy (RT). Patients and Methods From a collaborative data set of men with clinically localized prostate cancer treated with...http://www.medconnect.com.my/tabid/100/ct9/c460107/Validating-the-Interval-to-Biochemical-Failure-for-the-Identification/Default.aspx19-May-2012 Purpose To investigate changes in bone mineral density (BMD) and fracture risk in men who received intermittent androgen deprivation (IAD) for nonmetastatic, hormone-sensitive prostate cancer. Patients and Methods Men with prostate cancer who lacked radiographically detectable metastases were...http://www.medconnect.com.my/tabid/100/ct9/c460110/Long-Term-Dynamics-of-Bone-Mineral-Density-During-Intermittent-Androgen/Default.aspx19-May-2012 Purpose Bladder cancer is the second most common tobacco-related malignancy. A new bladder cancer diagnosis may be an opportunity to imprint smoking cessation. Little is known about the impact of a diagnosis of bladder cancer on patterns of tobacco use and smoking cessation among patients with...http://www.medconnect.com.my/tabid/100/ct9/c460112/Impact-of-a-Bladder-Cancer-Diagnosis-on-Smoking-Behavior-Urologic-Oncology-/Default.aspx19-May-2012 Triple-negative breast cancer (TNBC) accounts for 15% to 20% of breast cancers. It is a heterogeneous disease, not only on the molecular level, but also on the pathologic and clinical levels. TNBC is associated with a significantly higher probability of relapse and poorer overall survival in the...http://www.medconnect.com.my/tabid/100/ct9/c460115/Dissecting-the-Heterogeneity-of-Triple-Negative-Breast-Cancer-REVIEW-ARTICLE-/Default.aspx19-May-2012 Purpose The NORDIC-VII multicenter phase III trial investigated the efficacy of cetuximab when added to bolus fluorouracil/folinic acid and oxaliplatin (Nordic FLOX), administered continuously or intermittently, in previously untreated metastatic colorectal cancer (mCRC). The influence of KRAS...http://www.medconnect.com.my/tabid/100/ct9/c460077/Phase-III-Trial-of-Cetuximab-With-Continuous-or-Intermittent/Default.aspx19-May-2012 Purpose Over recent years, patient outcomes after colon cancer resection have not improved to the same degree as for rectal cancer. Japanese D3 resection and European complete mesocolic excision (CME) with central vascular ligation (CVL) are both based on sound oncologic principles. Expert...http://www.medconnect.com.my/tabid/100/ct9/c460079/Understanding-Optimal-Colonic-Cancer-Surgery-Comparison-of-Japanese-D3-Resection/Default.aspx19-May-2012 Purpose To report the results from a randomized trial comparing accelerated radiotherapy (AR) with accelerated radiotherapy plus carbogen inhalation and nicotinamide (ARCON) in laryngeal cancer. Patients and Methods Patients with cT2-4 squamous cell laryngeal cancer were randomly assigned to AR...http://www.medconnect.com.my/tabid/100/ct9/c460082/Accelerated-Radiotherapy-With-Carbogen-and-Nicotinamide-for-Laryngeal-Cancer-Results/Default.aspx19-May-2012 Estrogens affect a diversity of peripheral and central physiological endpoints. Traditionally, estrogens were thought to be peripherally derived transcription regulators (i.e. slow acting). More recently, we have learned that estrogens are also synthesized in neuronal cell bodies and synaptic...http://www.medconnect.com.my/tabid/100/ct9/c459963/Acute-and-Specific-Modulation-of-Presynaptic-Aromatization-in-the-Vertebrate-Brain/Default.aspx19-May-2012 1,25-dihydroxyvitamin D3 [1,25(OH)2D3 or calcitriol], the hormonally active vitamin D metabolite, exhibits anticancer actions in models of breast cancer and prostate cancer. Because CYP27B1 (1α-hydroxylase), the enzyme catalyzing 1,25(OH)2D3 formation in the kidney, is also expressed in...http://www.medconnect.com.my/tabid/100/ct9/c459967/Dietary-Vitamin-D3-and-1-25-Dihydroxyvitamin-D3-Calcitriol-Exhibit-Equivalent/Default.aspx19-May-2012 Individuals carrying heterozygous (hz) MEN1 (Multiple Endocrine Neoplasia Syndrome Type 1) germ line mutations develop endocrine tumors as a result of somatic loss of the wild-type (wt) allele. However, endocrine cell proliferation has been observed despite wt allele retention, indicating...http://www.medconnect.com.my/tabid/100/ct9/c459969/Accelerated-Proliferation-and-Differential-Global-Gene-Expression-in-Pancreatic/Default.aspx19-May-2012 In response to gonadectomy certain inbred mouse strains develop sex steroidogenic adrenocortical neoplasms. One of the hallmarks of neoplastic transformation is expression of GATA4, a transcription factor normally present in gonadal but not adrenal steroidogenic cells of the adult mouse. To show...http://www.medconnect.com.my/tabid/100/ct9/c459972/GATA4-Is-a-Critical-Regulator-of-Gonadectomy-Induced-Adrenocortical-Tumorigenesis/Default.aspx19-May-2012 Arachidonic acid metabolites are crucial mediators of inflammation in diabetes. Although eicosanoids are established modulators of pancreatic β-cell function, the role of prostacyclin (prostaglandin I2) is unknown. Therefore, this study aimed to analyze the role of prostacyclin in β-cell...http://www.medconnect.com.my/tabid/100/ct9/c459975/Mechanism-of-Prostacyclin-Induced-Potentiation-of-Glucose-Induced-Insulin-Secretion/Default.aspx19-May-2012 The enteroendocrine and enteric nervous systems convey signals through an overlapping network of regulatory peptides that act either as circulating hormones or as localized neurotransmitters within the gastrointestinal tract. Because recent studies invoke an important role for vasoactive...http://www.medconnect.com.my/tabid/100/ct9/c459978/Intestinotrophic-Glucagon-Like-Peptide-2-GLP-2-Activates-Intestinal-Gene-Expression/Default.aspx19-May-2012 The dorsal vagal complex of the hindbrain, including the nucleus of the solitary tract (NTS), receives neural and humoral afferents that contribute to the process of satiation. The gut peptide, cholecystokinin (CCK), promotes satiation by activating gastrointestinal vagal afferents that synapse in...http://www.medconnect.com.my/tabid/100/ct9/c459980/CCK-Induced-Reduction-of-Food-Intake-and-Hindbrain-MAPK-Signaling/Default.aspx19-May-2012 Leptin resistance is a feature of obesity that poses a significant therapeutic challenge. Any treatment that is effective to reduce body weight in obese patients must overcome or circumvent leptin resistance, which promotes the maintenance of excess body fat in obese individuals. Ciliary...http://www.medconnect.com.my/tabid/100/ct9/c459983/The-Anorectic-Effect-of-CNTF-Does-Not-Require-Action-in-Leptin-Responsive-Neurons/Default.aspx19-May-2012 Hypothalamic functions, including feeding behavior, show a high degree of plasticity throughout life. Doublecortin (DCX) is a marker of plasticity and neuronal migration expressed in the hypothalamus. Therefore, we wanted to map the fate of DCX+ cells in the arcuate nucleus (ARC) of the...http://www.medconnect.com.my/tabid/100/ct9/c459985/Involvement-of-Doublecortin-Expressing-Cells-in-the-Arcuate-Nucleus-in/Default.aspx19-May-2012 Visceral adiposity represents a high risk factor for type 2 diabetes, metabolic syndrome, and cardiovascular disease as well as various cancers. While studying sex hormone imbalance-induced early obesity and late onset of insulin resistance in FSH receptor knock out female mice, we identified a...http://www.medconnect.com.my/tabid/100/ct9/c459988/Novel-Genes-of-Visceral-Adiposity-Identification-of-Mouse-and/Default.aspx19-May-2012 This study sought to elucidate the relationship between skeletal muscle mitochondrial dysfunction, oxidative stress, and insulin resistance in two mouse models with differential susceptibility to diet-induced obesity. We examined the time course of mitochondrial dysfunction and insulin resistance...http://www.medconnect.com.my/tabid/100/ct9/c459990/Early-Mitochondrial-Adaptations-in-Skeletal-Muscle-to-Diet-Induced-Obesity-Are/Default.aspx19-May-2012 The acute phase response (APR) produces marked alterations in lipid and carbohydrate metabolism including decreasing plasma ketone levels. Fibroblast growth factor 21 (FGF21) is a recently discovered hormone that regulates lipid and glucose metabolism and stimulates ketogenesis. Here we...http://www.medconnect.com.my/tabid/100/ct9/c459993/FGF21-Is-Increased-by-Inflammatory-Stimuli-and-Protects-Leptin-Deficient/Default.aspx19-May-2012 Aromatase is essential for estrogen production and is the target of aromatase inhibitors, the most effective endocrine treatment for postmenopausal breast cancer. Peripheral tissues in women, including the breast, express aromatase via alternative promoters. Female mice lack the promoters that...http://www.medconnect.com.my/tabid/100/ct9/c459995/A-Humanized-Pattern-of-Aromatase-Expression-Is-Associated-with-Mammary/Default.aspx19-May-2012 Steroidogenic acute regulatory protein (StAR) facilitates cholesterol transfer into the inner mitochondrial membrane in the acute phase of steroidogenesis. Mice lacking StAR (Star–/–) share phenotypes with human individuals having congenital lipoid adrenal hyperplasia including...http://www.medconnect.com.my/tabid/100/ct9/c459998/A-Genome-Wide-Expression-Profile-of-Adrenocortical-Cells-in-Knockout/Default.aspx19-May-2012 Prolactin (PRL) is mainly expressed in the pituitary in rodents, whereas in humans, expression is observed in many extrapituitary sites, including lymphocytes. Due to the lack of adequate experimental models, the function of locally produced PRL in the immune system is largely unknown. Using...http://www.medconnect.com.my/tabid/100/ct9/c459999/Peritonitis-Activates-Transcription-of-the-Human-Prolactin-Locus-in/Default.aspx19-May-2012 The Ron receptor tyrosine kinase (macrophage stimulating 1 receptor) is overexpressed in approximately 50% of human breast cancers. Transgenic mice overexpressing Ron in the mammary epithelium [mouse mammary tumor virus driven (MMTV)-Ron expressing mice] develop mammary tumors that exhibit...http://www.medconnect.com.my/tabid/100/ct9/c460002/Conditional-Deletion-of-{beta}-Catenin-in-Mammary-Epithelial-Cells-of/Default.aspx19-May-2012 G protein signaling through human somatostatin receptor subtype 2 (SSTR2) is well known, but the amino acids involved in stimulation of intracellular responses upon ligand binding have not been characterized. We constructed a series of point mutants in SSTR2 at amino acid positions 89, 139, and...http://www.medconnect.com.my/tabid/100/ct9/c460004/Identification-of-Critical-Residues-Involved-in-Ligand-Binding-and/Default.aspx19-May-2012 Puberty onset in female sheep is marked by a decrease in estradiol-negative feedback, allowing for the increase in GnRH and LH pulses that heralds the first ovulation. Based on recent genetic studies in humans, two possible neuropeptides that could promote puberty onset are kisspeptin and...http://www.medconnect.com.my/tabid/100/ct9/c460007/Evidence-of-a-Role-for-Kisspeptin-and-Neurokinin-B-in-Puberty-of-Female-Sheep/Default.aspx19-May-2012 Amino acid (aa) neurotransmitters in synaptic afferents to hypothalamic GnRH-I neurons are critically involved in the neuroendocrine control of reproduction. Although in rodents the major aa neurotransmitter in these afferents is -aminobutyric acid (GABA), glutamatergic axons also innervate GnRH...http://www.medconnect.com.my/tabid/100/ct9/c460009/Glutamatergic-and-GABAergic-Innervation-of-Human-Gonadotropin-Releasing-Hormone-I/Default.aspx19-May-2012 Although several lines of evidence have indicated that menopause is associated with increased susceptibility to neurological disorders, the mechanisms involved in this phenomenon remain to be elucidated. Because neuroinflammation is a common feature of a number of brain diseases, we hypothesized...http://www.medconnect.com.my/tabid/100/ct9/c460012/A-Lack-of-Ovarian-Function-Increases-Neuroinflammation-in-Aged-Mice/Default.aspx19-May-2012 Age-related depletion of estrogens and androgens is associated with an increase in Alzheimer's disease (AD) brain pathology and diminished cognitive function. Here we investigated AD-associated molecular and cellular changes in brains of aged hypogonadal (hpg) male and female mice. hpg Mice have a...http://www.medconnect.com.my/tabid/100/ct9/c460014/Altered-Expression-of-Alzheimers-Disease-Related-Proteins-in-Male-Hypogonadal-Mice/Default.aspx19-May-2012 Estrogen withdrawal increases gonadotropin secretion and body weight, but the critical cell populations mediating these effects are not well understood. Recent studies have focused on a subpopulation of hypothalamic arcuate neurons that coexpress estrogen receptor α, neurokinin 3 receptor...http://www.medconnect.com.my/tabid/100/ct9/c460017/Arcuate-Kisspeptin-Neurokinin-B-Dynorphin-KNDy-Neurons-Mediate-the-Estrogen/Default.aspx19-May-2012 Prenatal testosterone (T) excess compromises the estradiol (E2) positive feedback. This study tested the hypothesis that antagonizing androgen action or improving insulin sensitivity prenatally would prevent positive feedback disruptions from developing, whereas postnatal intervention with...http://www.medconnect.com.my/tabid/100/ct9/c460020/Developmental-Programming-Prenatal-and-Postnatal-Contribution-of-Androgens-and/Default.aspx19-May-2012 The links between obesity in parents and their offspring and the role of genes and a shared environment are not completely understood. Adipocytokines such as leptin and adiponectin play important roles in glucose and lipid metabolism. Therefore, we examined whether the offspring from dams exposed...http://www.medconnect.com.my/tabid/100/ct9/c460023/Effects-of-a-High-Fat-Diet-Exposure-in-Utero-on/Default.aspx19-May-2012 We have previously reported that 5α-dihydrotestosterone (DHT) inhibits FSH-mediated granulosa cell proliferation by reducing cyclin D2 mRNA expression and blocking cell cycle progression at G1/S phase. The present study investigated the role of AMP activated protein kinase (AMPK) in...http://www.medconnect.com.my/tabid/100/ct9/c460025/AMPK-Activation-by-Dihydrotestosterone-Reduces-FSH-Stimulated-Cell-Proliferation-in/Default.aspx19-May-2012 Ovulation in mammals is gated by a master circadian clock in the suprachiasmatic nucleus (SCN). GnRH neurons represent the converging pathway through which the brain triggers ovulation, but precisely how the SCN times GnRH neurons is unknown. We tested the hypothesis that neurons expressing...http://www.medconnect.com.my/tabid/100/ct9/c460028/The-Dorsomedial-Suprachiasmatic-Nucleus-Times-Circadian-Expression-of-Kiss1/Default.aspx19-May-2012 The ovary is a complex endocrine organ responsible for steroidogenesis and folliculogenesis. Follicles consist of oocytes and two primary steroidogenic cell types, the granulosa cells, and the theca cells. Immortalized human granulosa cells are essential for researching the mechanism of...http://www.medconnect.com.my/tabid/100/ct9/c460030/Establishment-of-a-Human-Nonluteinized-Granulosa-Cell-Line-that/Default.aspx19-May-2012 Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women in their reproductive age, is characterized by both reproductive and metabolic features. Recent studies in human, nonhuman primates, and sheep suggest that hyperandrogenism plays an important role in the development of...http://www.medconnect.com.my/tabid/100/ct9/c460033/Reproductive-and-Metabolic-Phenotype-of-a-Mouse-Model-of-PCOS/Default.aspx19-May-2012 The human endometrium undergoes extensive monthly regeneration in response to fluctuating levels of circulating estrogen and progesterone in premenopausal (Pre-M) women. In contrast, postmenopausal (Post-M) endometrium is thin and quiescent with low mitotic activity, similar to the Pre-M...http://www.medconnect.com.my/tabid/100/ct9/c460035/Differential-Expression-of-Wnt-Signaling-Molecules-Between-Pre-and/Default.aspx19-May-2012 No other tissue in the body undergoes such a vast and extensive growth and remodeling in a relatively short period of time as the primate endometrium. Endometrial integrity is coordinated by ovarian hormones, namely, estrogens, progesterone, and the embryonic hormone chorionic gonadotropin (CG)....http://www.medconnect.com.my/tabid/100/ct9/c460038/Notch1-Is-Regulated-by-Chorionic-Gonadotropin-and-Progesterone-in-Endometrial/Default.aspx19-May-2012 We previously showed that advancing the increase in estradiol levels from the second to the first third of baboon pregnancy suppressed placental extravillous trophoblast (EVT) invasion and remodeling of the uterine spiral arteries. Cell culture studies show that vascular endothelial cell growth...http://www.medconnect.com.my/tabid/100/ct9/c460040/Prematurely-Elevating-Estradiol-in-Early-Baboon-Pregnancy-Suppresses-Uterine/Default.aspx19-May-2012 Endothelin (ET) receptor dysregulation has been described in a number of pathophysiological processes, including cardiovascular disorders, renal failure, and cancer. The aim of this study was to evaluate the expression of the ET-A receptor (ETAR) in murine models of thyroid carcinoma using optical...http://www.medconnect.com.my/tabid/100/ct9/c460043/Assessment-of-Endothelin-A-Receptor-Expression-in-Subcutaneous-and-Orthotopic-Thyroid/Default.aspx19-May-2012 Thyroid hormones regulate brain development and function through the control of gene expression, mediated by binding of T3 to nuclear receptors. Brain T3 concentration is tightly controlled by homeostatic mechanisms regulating transport and metabolism of T4 and T3. We have examined the role of the...http://www.medconnect.com.my/tabid/100/ct9/c460045/Critical-Role-of-Types-2-and-3-Deiodinases-in/Default.aspx19-May-2012 Sex influences are proving to be extremely widespread on brain function, including the human brain. Ample evidence now proves that the sex of subjects can influence, ever reverse, findings, hence conclusions, at all levels of brain science, down to the molecular level, often in completely...http://www.medconnect.com.my/tabid/100/ct9/c459957/A-Half-Truth-Is-a-Whole-Lie-On-the-Necessity/Default.aspx19-May-2012 Males and females have the same immunological cells, proteins, and pathways in place to protect against the development of disease. The kinetics, magnitude, and skewing of the responses mounted against pathogens, allergens, toxins, or self-antigens, however, can differ dramatically between the...http://www.medconnect.com.my/tabid/100/ct9/c459959/Immune-Cells-Have-Sex-and-So-Should-Journal-Articles/Default.aspx19-May-2012 The current male bias in biomedical research should be eliminated. The large sex differences in incidence and progression of diseases mean that sex-biased factors are an untapped source of factors that protect from disease. Greater understanding will come from intensified study of the "sexome,"...http://www.medconnect.com.my/tabid/100/ct9/c459961/Understanding-the-Sexome-Measuring-and-Reporting-Sex-Differences-in-Gene-Systems/Default.aspx19-May-2012We have previously reported that the absence of leptin signaling in β-cells enhances glucose-stimulated insulin secretion and improves glucose tolerance in vivo. To investigate the relevance of β-cell leptin signaling in the context of postprandial or therapeutic insulin secretion, we examined the...http://www.medconnect.com.my/tabid/100/ct9/c459933/Enhanced-GLP-1-and-Sulfonylurea-Induced-Insulin-Secretion-in-Islets-Lacking/Default.aspx19-May-2012Peroxisome proliferator-activated receptor γ (PPARγ) is expressed at low levels in skeletal muscle, where it protects against adiposity and insulin resistance via unclear mechanisms. To test the hypothesis that PPARγ directly modulates skeletal muscle metabolism, we created two models that isolate...http://www.medconnect.com.my/tabid/100/ct9/c459936/Peroxisome-Proliferator-Activated-Receptor-{gamma}-Decouples-Fatty-Acid-Uptake-from/Default.aspx19-May-2012MicroRNA-375 (miR-375) is necessary for proper formation of pancreatic islets in vertebrates and is necessary for the development of β-cells in mice, but regulation of miR-375 in these cells is poorly understood. Here, we show that miR-375 is transcriptionally repressed by the cAMP-protein kinase A...http://www.medconnect.com.my/tabid/100/ct9/c459939/Regulation-of-microRNA-375-by-cAMP-in-Pancreatic-{beta}-Cells/Default.aspx19-May-2012The glucocorticoid-induced leucine zipper (Tsc22d3-2) is a widely expressed dexamethasone-induced transcript that has been proposed to be important in immunity, adipogenesis, and renal sodium handling based on in vitro studies. To address its function in vivo, we have used Cre/loxP technology to...http://www.medconnect.com.my/tabid/100/ct9/c459942/The-Glucocorticoid-Induced-Leucine-Zipper-Gilz-Tsc22d3-2-Gene-Locus-Plays-a-Crucial/Default.aspx19-May-2012The pituitary is a complex gland comprising different cell types each secreting specific hormones. The extensive network of signaling molecules and transcription factors required for determination and terminal differentiation of specific cell types is still not fully understood. The SRY-like...http://www.medconnect.com.my/tabid/100/ct9/c459945/The-HMG-Box-Transcription-Factor-Sox4b-Is-Required-for-Pituitary-Expression/Default.aspx19-May-2012miR-93/106b and their host gene minichromosome maintenance complex component 7 (MCM7) reside at chr7q22, a region frequently rearranged in leiomyomas. We explored the expression of miR-93/106b in leiomyoma and paired myometrium (n = 63) from untreated and patients exposed to hormonal therapies...http://www.medconnect.com.my/tabid/100/ct9/c459948/miR-93-106b-and-Their-Host-Gene-MCM7-Are-Differentially-Expressed-in/Default.aspx19-May-2012We previously demonstrated that long-term pretreatment of rat FRTL-5 thyroid cells with TSH or cAMP-generating reagents potentiated IGF-I-dependent DNA synthesis. Under these conditions, cAMP treatment increased tyrosine phosphorylation of a 125-kDa protein (p125) and its association with a p85...http://www.medconnect.com.my/tabid/100/ct9/c459951/Phosphatidylinositol-3-Kinase-Binding-Protein-PI3KAP-XB130-Is-Required-for/Default.aspx19-May-2012GH and GH receptors are expressed throughout life, and GH elicits a diverse range of responses, including growth and altered metabolism. It is therefore important to understand the full spectrum of GH signaling pathways and cellular responses. We applied mass spectrometry-based phosphoproteomics...http://www.medconnect.com.my/tabid/100/ct9/c459954/Research-Resource-Identification-of-Novel-Growth-Hormone-Regulated-Phosphorylation/Default.aspx19-May-2012Rod and cone photoreceptors are specialized sensory cells that mediate vision. Transcriptional controls are critical for the development and long-term survival of photoreceptors; when these controls become ineffective, retinal dysfunction or degenerative disease may result. This review discusses...http://www.medconnect.com.my/tabid/100/ct9/c459918/Minireview-The-Role-of-Nuclear-Receptors-in-Photoreceptor-Differentiation/Default.aspx19-May-2012The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a broad-specificity nuclear hormone receptor that is well known for its role in drug and xenobiotic metabolism. SXR is activated by a wide variety of endobiotics, dietary compounds, pharmaceuticals, and...http://www.medconnect.com.my/tabid/100/ct9/c459921/The-Steroid-and-Xenobiotic-Receptor-Negatively-Regulates-B-1-Cell/Default.aspx19-May-2012Thyroid hormones have a profound influence on human development and disease. The hypothalamic-pituitary-thyroid axis involves finely tuned feedback mechanisms to maintain thyroid hormone (TH) levels. Despite the important role of TH-negative feedback in regulating this axis, the mechanism by which...http://www.medconnect.com.my/tabid/100/ct9/c459924/Fundamentally-Distinct-Roles-of-Thyroid-Hormone-Receptor-Isoforms-in/Default.aspx19-May-2012The tumor microenvironment plays a critical role in supporting cancer cells particularly as they disengage from limitations on their growth and motility imposed by surrounding nonreactive stromal cells. We show here that stromal-derived androgenic precursors are metabolized by DU145 human prostate...http://www.medconnect.com.my/tabid/100/ct9/c459927/A-Local-Paracrine-and-Endocrine-Network-Involving-TGF{beta}-Cox-2-ROS-/Default.aspx19-May-2012Progesterone receptor (PgR) controls the menstrual cycle, pregnancy, embryonic development, and homeostasis, and it plays important roles in breast cancer development and progression. However, the requirement of coregulators for estrogen-induced expression of the PgR gene has not been fully...http://www.medconnect.com.my/tabid/100/ct9/c459930/Gene-Specific-Patterns-of-Coregulator-Requirements-by-Estrogen-Receptor-{alpha}-in/Default.aspx19-May-2012No abstract availablehttp://www.medconnect.com.my/tabid/100/ct9/c461063/Which-Method-Is-Best-for-Imaging-of-Anal-Sphincter-Defects-/Default.aspx19-May-2012BACKGROUND: Preoperative clinical diagnosis of lymph node involvement guides treatment decisions for rectal cancer. Unfortunately, clinical staging still suffers from a lack of accuracy. OBJECTIVE: The aim of this study was to evaluate objective genetic differences in primary rectal cancers with...http://www.medconnect.com.my/tabid/100/ct9/c461064/High-Throughput-Arrays-Identify-Distinct-Genetic-Profiles-Associated-With-Lymph/Default.aspx19-May-2012BACKGROUND: Improvements in outcome after surgery for elective pilonidal sinus disease have yet to be matched for those presenting with acute disease. Traditional approaches to the management of acute pilonidal abscess have been associated with slow healing and significant loss of working...http://www.medconnect.com.my/tabid/100/ct9/c461065/Converting-Emergency-Pilonidal-Abscess-Into-an-Elective-Procedure/Default.aspx19-May-2012BACKGROUND: Endoanal ultrasound is widely used for the detection of external and internal anal sphincter defects in patients with fecal incontinence. Recently, 3-dimensional transperineal ultrasound has been introduced as a noninvasive imaging method for the detection of these sphincter...http://www.medconnect.com.my/tabid/100/ct9/c461066/Detection-of-Anal-Sphincter-Defects-in-Female-Patients-With/Default.aspx19-May-2012BACKGROUND: Lynch syndrome is a disorder caused by mismatch repair gene mutations. Mutation carriers have a high risk of developing colorectal cancer. In patients with Lynch syndrome in whom colon cancer has been diagnosed, in general, subtotal colectomy instead of partial colectomy is recommended...http://www.medconnect.com.my/tabid/100/ct9/c461067/Quality-of-Life-After-Surgery-for-Colon-Cancer-in/Default.aspx19-May-2012BACKGROUND: There are multiple procedures to treat full-thickness rectal prolapse. No consensus exists as to the best surgical option. All procedures have a significant recurrence rate. OBJECTIVE: The aim of this study was to report short- and long-term technical results following laparoscopic...http://www.medconnect.com.my/tabid/100/ct9/c461068/Laparoscopic-Anterior-Rectopexy-to-the-Promontory-for-Full-Thickness-Rectal/Default.aspx19-May-2012BACKGROUND: The surgical approach to recurrent full-thickness rectal prolapse after perineal rectosigmoidectomy is complicated by recurrent prolapse. The majority of patients who undergo perineal rectosigmoidectomy are elderly with comorbidities. Therefore, redo perineal rectosigmoidectomy is...http://www.medconnect.com.my/tabid/100/ct9/c461069/Perineal-Rectosigmoidectomy-for-Primary-and-Recurrent-Rectal-Prolapse-/Default.aspx19-May-2012BACKGROUND: Limited information exists on what constitutes normal bowel function in children and adolescents. This information is essential for determining outcomes of surgery for anorectal malformations and other colonic disorders. OBJECTIVE: The aim of this study was to define bowel function and...http://www.medconnect.com.my/tabid/100/ct9/c461070/Evaluation-of-Bowel-Function-and-Fecal-Continence-in-594/Default.aspx19-May-2012BACKGROUND: Lymph node metastasis is an important indicator of oncologic outcome for patients with rectal cancer. Identifying predictive biomarkers of lymph node metastasis could therefore be clinically useful. OBJECTIVE: The aim of this study was to assess whether chromosomal copy number...http://www.medconnect.com.my/tabid/100/ct9/c461071/Chromosomal-Copy-Number-Alterations-Are-Associated-with-Persistent-Lymph/Default.aspx19-May-2012BACKGROUND: Locally advanced and recurrent colorectal cancers pose a significant therapeutic challenge. Orthovoltage intraoperative radiotherapy provides one potential means of improving disease control at the time of surgery. OBJECTIVE: This study sought to analyze outcomes and identify...http://www.medconnect.com.my/tabid/100/ct9/c461072/Orthovoltage-Intraoperative-Radiotherapy-for-Locally-Advanced-and-Recurrent/Default.aspx19-May-2012BACKGROUND: Alcohol is considered to be a cocarcinogen or a tumor promoter, and various studies have shown a linear dose-dependent association between alcohol consumption and colorectal cancer. However, a few studies suggest that moderate alcohol consumption may have a protective effect, similar to...http://www.medconnect.com.my/tabid/100/ct9/c461073/Alcohol-Consumption-and-Colorectal-Cancer-in-a-Mediterranean-Population-/Default.aspx19-May-2012BACKGROUND: Fecal incontinence is an increasingly common condition with significant negative impact on quality on life and health care resources. It frequently presents a therapeutic challenge to clinicians. Emerging evidence suggests that percutaneous tibial nerve stimulation is an effective...http://www.medconnect.com.my/tabid/100/ct9/c461074/Percutaneous-Tibial-Nerve-Stimulation-for-Fecal-Incontinence-A-Video-Demonstration/Default.aspx19-May-2012BACKGROUND: The Heineke-Mikulicz and Finney techniques are conventional strictureplasties that have been used to manage short (10 cm and 20 cm) strictures from Crohn’s disease. Nonconventional strictureplasty techniques have emerged to facilitate bowel conservation for atypical strictures. These...http://www.medconnect.com.my/tabid/100/ct9/c461075/Comparison-of-Conventional-and-Nonconventional-Strictureplasties-in-Crohn-s-Disease-/Default.aspx19-May-2012 Euthyroid status is essential for normal skeletal development and the maintenance of adult bone structure and strength. Established thyrotoxicosis has long been recognised as a cause of high bone turnover osteoporosis and fracture but more recent studies have suggested that subclinical...http://www.medconnect.com.my/tabid/100/ct9/c460056/The-skeletal-consequences-of-thyrotoxicosis/Default.aspx18-May-2012 3-Iodothyronamine (T1AM) is a novel chemical messenger, structurally related to thyroid hormone, able to interact with G protein-coupled receptors known as trace amine-associated receptors (TAARs). Little is known about the physiological role of T1AM. In this prospective, we synthesized...http://www.medconnect.com.my/tabid/100/ct9/c460059/Distribution-of-exogenous-125I-3-iodothyronamine-in-mouse-in-vivo-relationship/Default.aspx18-May-2012 Pituitary folliculostellate (FS) cells are characterized by producing S100B protein, as do brain astrocytes. FS cells have some functions in the pituitary gland, i.e. scavenger functions, sustentacular cell activity through cytokines, and intercellular communication through gap junctions. However,...http://www.medconnect.com.my/tabid/100/ct9/c460061/Differentiation-capacity-of-native-pituitary-folliculostellate-cells-and-brain/Default.aspx18-May-2012 DP71 is the major cerebral dystrophin isoform and exerts its multiple functions via the dystrophin-associated protein complex (DAPC), also comprised of β-dystroglycan (β-DG) and α1-syntrophin (α1-Syn). Since DP71 disruption leads to impairment in the central control of the...http://www.medconnect.com.my/tabid/100/ct9/c460063/Dp71-gene-disruption-alters-the-composition-of-the-dystrophin-associated/Default.aspx18-May-2012 Excessive fat accumulation in liver (hepatic steatosis) predisposes to hepatic functional and structural impairment and overall metabolic risk. Previous studies noted an association between hepatic steatosis and age in humans and rodents. However, the mechanisms leading to age-associated hepatic...http://www.medconnect.com.my/tabid/100/ct9/c460065/Role-of-{beta}-adrenergic-receptors-in-regulation-of-hepatic-fat/Default.aspx18-May-2012 We investigated the potential anorectic action of peripherally administered glucagon-like peptide 2 (GLP2) in lean and diet-induced obese (DIO) mice. Mice, fasted for 16 h, were injected i.p. with native GLP2 or [Gly2]GLP2, stable analog of GLP2, before or after GLP2 (3–33), a GLP2 receptor...http://www.medconnect.com.my/tabid/100/ct9/c460068/Food-intake-in-lean-and-obese-mice-after-peripheral/Default.aspx18-May-2012 Obesity induces hypertrophy of adipocyte resulting in production of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein 1 (MCP1 (CCL2)). These cytokines play an important role in the development of insulin resistance. Beraprost sodium...http://www.medconnect.com.my/tabid/100/ct9/c460070/Beraprost-sodium-a-stable-prostacyclin-analogue-improves-insulin-resistance/Default.aspx18-May-2012A fitness boxing gym in the West Village offers more than a pacifist might expect. (Source: NYT)MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctorshttp://www.medconnect.com.my/tabid/100/ct9/c460835/Urban-Athlete-Fitness-Boxing-in-the-West-Village/Default.aspx18-May-2012A video game designed to rehabilitate stroke patients, gene therapy for a form of blindness, and an implantable device to monitor pulmonary hypertension are some of the projects being supported by... http://www.medconnect.com.my/tabid/100/ct9/c460145/Innovation-fund-supports-video-game-to-help-stroke-patients-regain-movement/Default.aspx18-May-2012A Canadian woman is thought to have become the first patient to receive a new vital organ from an unrelated, altruistic donor who answered an appeal launched on social media.Lucia Andrade, 61, of... http://www.medconnect.com.my/tabid/100/ct9/c460146/Patient-who-received-liver-after-social-media-campaign-reports-success/Default.aspx18-May-2012Members of Canada’s cabinet have engaged in a war of words with the United Nations’ special rapporteur on the right to food, who accused the government of widening inequalities in society and failing... http://www.medconnect.com.my/tabid/100/ct9/c460148/Canadian-MPs-dismiss-findings-that-food-policies-are-leading-to-hunger-and-obesity/Default.aspx18-May-2012Review found fewer excess pounds and complications with healthy diet vs. exercise (Source: The Doctors Lounge - Health News)http://www.medconnect.com.my/tabid/100/ct9/c460837/Healthy-Dieting-in-Pregnancy-May-Be-Helpful/Default.aspx18-May-2012Objective To assess the reporting, extent, and handling of loss to follow-up and its potential impact on the estimates of the effect of treatment in randomised controlled trials.Design Systematic... http://www.medconnect.com.my/tabid/100/ct9/c460150/Potential-impact-on-estimated-treatment-effects-of-information-lost/Default.aspx18-May-2012Some will be aware that the ever expanding repertoire of monoclonal antibody drugs benefits from systematic naming rules, but for those who are not, there is hope: we can understand the... http://www.medconnect.com.my/tabid/100/ct9/c460151/How-to-remember-biological-therapeutics/Default.aspx18-May-2012Imagine a hypothetical condition that affects about 1 in 200 hospitalised general medical patients and that can occasionally be fatal. Imagine that the drug used to treat this condition could also be... http://www.medconnect.com.my/tabid/100/ct9/c460153/Prophylaxis-rates-for-venous-thromboembolism-and-gastrointestinal-bleeding-in-general/Default.aspx18-May-2012Recently I suffered from a cold severe enough to land me in bed for three days on wife’s orders. I do not mention this to arouse the reader’s sympathy, only to draw attention to the truth of what... http://www.medconnect.com.my/tabid/100/ct9/c460154/An-antiepidemiologist/Default.aspx18-May-2012For many of us, the ghost at the table of our early clinical education was syphilis. The great imitator, we were warned, was potentially always around the next corner. Anxiously, we sought out... http://www.medconnect.com.my/tabid/100/ct9/c460155/String-quartets-by-Bedrich-Smetana/Default.aspx18-May-2012The National Institute for Health and Clinical Excellence (NICE) has amended draft guidance on the drug abiraterone (marketed in the United Kingdom as Zytiga) for men with advanced prostate cancer... http://www.medconnect.com.my/tabid/100/ct9/c460157/NICE-recommends-abiraterone-for-prostate-cancer-after-manufacturer-reduces-price/Default.aspx18-May-2012Go ahead and pour a second cup this morning — new research indicates coffee drinkers are likely to live longer, despite their bad habits, The Associated Press reports. A large study including about 400,000 indicates that instead of raising risks for heart disease as previously thought, coffee has...http://www.medconnect.com.my/tabid/100/ct9/c460842/Study-shows-coffee-drinkers-live-longer/Default.aspx18-May-2012what do cathode ray tubes, "Blue John" and moon rocks have in common?This week, we meet the rare earths element, europium, which has the atomic number 63 and the symbol Eu. Europium is a silvery-coloured element that is ductile. It also is highly reactive since its outer (valence) electron shell is...http://www.medconnect.com.my/tabid/100/ct9/c460846/Europium-|-video-|-GrrlScientist/Default.aspx18-May-2012Object control skills provide children the tools to be physically active-a major societal priority. At the fundamental movement level, object control skills form the foundation of further sports skill development. The purpose of this study was to examine c... (Source: SafetyLit: All (Unduplicated))http://www.medconnect.com.my/tabid/100/ct9/c460851/Age-and-sex-differences-in-object-control-skills-by/Default.aspx18-May-2012The aim of this study was to monitor injury incidence and pattern in Norwegian male professional football over six consecutive seasons and compare the risk of injury between the preseason and competitive season. All time loss injuries were recorded by the ... (Source: SafetyLit: All...http://www.medconnect.com.my/tabid/100/ct9/c460855/Gradual-increase-in-the-risk-of-match-injury-in-Norwegian/Default.aspx18-May-2012The sudden death in athletes is, in the vast majority of cases, related to ventricular fibrillation, often in a subject with unknown cardiovascular abnormality; this dramatic event has a significant impact on society and the medical profession. We conducte... (Source: SafetyLit: All (Unduplicated))http://www.medconnect.com.my/tabid/100/ct9/c460859/Sudden-Cardiac-Death-of-Rhythmic-Origin-in-Athletes-Literature/Default.aspx18-May-2012(Source: Sports Medicine)http://www.medconnect.com.my/tabid/100/ct9/c460863/Impact-of-Breath-Holding-on-Cardiovascular-Respiratory-and-Cerebrovascular-Health/Default.aspx18-May-2012(Source: Sports Medicine)http://www.medconnect.com.my/tabid/100/ct9/c460867/Exercise-Training-in-Chronic-Kidney-Disease-Patients/Default.aspx18-May-2012(Source: Sports Medicine)http://www.medconnect.com.my/tabid/100/ct9/c460871/The-Potential-for-High-Intensity-Interval-Training-to-Reduce-Cardiometabolic/Default.aspx18-May-2012(Source: Sports Medicine)http://www.medconnect.com.my/tabid/100/ct9/c460875/Exercise-Training-Intervention-Studies-in-Competitive-Swimming/Default.aspx18-May-201205/17/2012, The Cochrane Library, Not only is it safe for people with asthma to exercise, but doing so could reduce their risk of asthma symptoms or attacks, according to a new evidence review in The Cochrane Library. (Source: Health Behavior News Service)http://www.medconnect.com.my/tabid/100/ct9/c460879/People-with-Asthma-Get-the-Green-Light-for-Exercise/Default.aspx18-May-2012(Source: Sports Medicine)http://www.medconnect.com.my/tabid/100/ct9/c460883/Genetic-Inheritance-Effects-on-Endurance-and-Muscle-Strength-An-Update/Default.aspx18-May-2012Conclusion: The German fibromyalgia consumer reports highlight the importance of non-pharmcological therapies in the long-term management of FMS, and challenges the strong recommendationsfor drug therapies given by FMS-guidelines. (Source: BMC Musculoskeletal Disorders)http://www.medconnect.com.my/tabid/100/ct9/c460887/German-fibromyalgia-consumer-reports-a-crosssectional-survey/Default.aspx18-May-2012Background: Previous studies reported divergent results on nutraceutical actions and free radicalscavenging capability of ginseng extracts. Variations in ginsenoside profile of ginseng due todifferent soil and cultivating season may contribute to the inconsistency. To circumvent thisdrawback, we...http://www.medconnect.com.my/tabid/100/ct9/c460891/Oral-Rg1-supplementation-strengthens-antioxidant-defense-system-against/Default.aspx18-May-2012Conclusions: Our data demonstrates that exposure of human synovial fibroblasts to SAA promotes MSU-mediated caspase-1 activation and IL-1beta secretion in the absence of microbial stimulation. These findings provide insight into the molecular processes underlying the synovial inflammatory condition...http://www.medconnect.com.my/tabid/100/ct9/c460828/Serum-amyloid-A-triggers-the-MSU-mediated-mature-interleukin-1beta-production/Default.aspx18-May-2012Objective To evaluate the effects of dietary and lifestyle interventions in pregnancy on maternal and fetal weight and to quantify the effects of these interventions on obstetric outcomes.Design... http://www.medconnect.com.my/tabid/100/ct9/c459432/Effects-of-interventions-in-pregnancy-on-maternal-weight-and/Default.aspx18-May-2012Obesity in pregnant women has considerable resource implications, with increased odds of caesarean or instrumental delivery, haemorrhage, infection, longer duration of hospital stay, and need for... http://www.medconnect.com.my/tabid/100/ct9/c459438/How-should-women-be-advised-on-weight-management-in-pregnancy-/Default.aspx18-May-2012 The recent paper by Scholefield and colleagues1 on the 20 year follow-up of the ‘Nottingham’ randomised controlled trial of guaiac based faecal occult blood test (gFOBT) colorectal cancer (CRC) screening, reports an intention to screen benefit of 13% reduced mortality from CRC and a...http://www.medconnect.com.my/tabid/100/ct9/c459293/Guaiac-based-faecal-occult-blood-testing-for-colorectal-cancer-screening-/Default.aspx18-May-2012 Important advances are being made in our understanding of the composition and function of the large amount of commensal bacteria that the human intestine has long been known to contain. Metagenomic sequencing has shown that the microbiome of healthy individuals is different from that of patients...http://www.medconnect.com.my/tabid/100/ct9/c459294/A-major-advance-in-ex-vivo-intestinal-organ-culture/Default.aspx18-May-2012 Together with immunosuppressants, anti-tumour necrosis factor (TNF) monoclonal antibodies represent a major class of treatment for the inflammatory bowel diseases (IBD) therapeutic arsenal. Almost 20 years after the first report of infliximab in Crohn's disease,1 we do not know exactly how...http://www.medconnect.com.my/tabid/100/ct9/c459295/The-multiple-effects-of-tumour-necrosis-factor-inhibitors-on/Default.aspx18-May-2012 Helicobacter pylori is a Gram-negative bacterium that is highly adapted for persistent colonisation of the human stomach. Although most H pylori-infected people remain asymptomatic, the presence of this organism is a risk factor for gastric adenocarcinoma, peptic ulcer disease and gastric...http://www.medconnect.com.my/tabid/100/ct9/c459296/Role-of-Helicobacter-pylori-CagL-in-modulating-gastrin-expression/Default.aspx18-May-2012 Background Cirrhosis is one of the most frequent and severe chronic diseases worldwide. In the initial stages it has few or no symptoms, but advanced stages of cirrhosis are characterised by reduced liver function, complications due to portal hypertension and neuroendocrine abnormalities with...http://www.medconnect.com.my/tabid/100/ct9/c459297/The-window-hypothesis-haemodynamic-and-non-haemodynamic-effects-of-{beta}-blockers/Default.aspx18-May-2012 Introduction The risk of oesophageal adenocarcinoma (OAC) in non-dysplastic Barrett's oesophagus (BO) may have been overestimated. The objective was to estimate the incidence of OAC in patients with BO without dysplasia. Methods The authors searched MEDLINE and EMBASE from 1966 to 2011 and...http://www.medconnect.com.my/tabid/100/ct9/c459298/The-incidence-of-oesophageal-adenocarcinoma-in-non-dysplastic-Barretts-oesophagus-a/Default.aspx18-May-2012 Objective Using genome-wide promoter methylation assay, B cell CLL/lymphoma 6 member B (BCL6B) was found to be preferentially methylated in cancer. A study was undertaken to examine the epigenetic regulation, biological function and clinical significance of BCL6B in gastric cancer...http://www.medconnect.com.my/tabid/100/ct9/c459299/Epigenetic-inactivation-of-BCL6B-a-novel-functional-tumour-suppressor/Default.aspx18-May-2012 Objective One of the most important hormones in the human stomach is the peptide gastrin. It is mainly required for the regulation of gastric pH but is also involved in growth and differentiation of gastric epithelial cells. In Helicobacter pylori infected patients, gastrin secretion can be...http://www.medconnect.com.my/tabid/100/ct9/c459300/Helicobacter-pylori-CagL-dependent-induction-of-gastrin-expression-via/Default.aspx18-May-2012 Background and aims Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder that may be triggered by enteric pathogens and has also been linked to alterations in the microbiota and the host immune response. The authors performed a detailed analysis of the faecal microbiota...http://www.medconnect.com.my/tabid/100/ct9/c459301/An-irritable-bowel-syndrome-subtype-defined-by-species-specific-alterations-in/Default.aspx18-May-2012 Background and aims Probiotics and their metabolic products, here called postbiotics, have been proposed as food supplements for a healthier intestinal homeostasis, but also as therapeutic aids in inflammatory bowel disease (IBD) with, however, very little clinical benefit. This may be due to the...http://www.medconnect.com.my/tabid/100/ct9/c459302/Probiotic-and-postbiotic-activity-in-health-and-disease-comparison/Default.aspx18-May-2012 Background Tumour necrosis factor α (TNFα) inhibitors such as adalimumab and infliximab are frequently prescribed for inflammatory bowel disease (IBD). Despite the clinical success of TNFα inhibitors, their physiological mode of action is not fully understood. The aim of this...http://www.medconnect.com.my/tabid/100/ct9/c459303/TNF{alpha}-inhibitors-restrict-T-cell-activation-and-cycling-via/Default.aspx18-May-2012 Objective The NOX2 NADPH oxidase complex produces reactive oxygen species and plays a critical role in the killing of microbes by phagocytes. Genetic mutations in genes encoding components of the complex result in both X-linked and autosomal recessive forms of chronic granulomatous disease (CGD)....http://www.medconnect.com.my/tabid/100/ct9/c459304/NADPH-oxidase-complex-and-IBD-candidate-gene-studies-identification/Default.aspx18-May-2012 Background Three large randomised trials have shown that screening for colorectal cancer (CRC) using the faecal occult blood test (FOBt) can reduce the mortality from this disease. The largest of these trials, conducted in Nottingham since 1981, randomised 152 850 individuals between the ages of...http://www.medconnect.com.my/tabid/100/ct9/c459305/Nottingham-trial-of-faecal-occult-blood-testing-for-colorectal/Default.aspx18-May-2012 Objective Colon cancer is a leading cause of cancer deaths in Western countries and is associated with diets high in red meat. Haem, the iron-porphyrin pigment of red meat, induces cytotoxicity of gut contents and damages the colon surface epithelium. Compensatory hyperproliferation leads to...http://www.medconnect.com.my/tabid/100/ct9/c459306/Dietary-haem-stimulates-epithelial-cell-turnover-by-downregulating-feedback/Default.aspx18-May-2012 Objectives Colonoscopy is central to colorectal cancer (CRC) screening. Success of CRC screening is dependent on colonoscopy quality. The NHS Bowel Cancer Screening Programme (BCSP) offers biennial faecal occult blood (FOB) testing to 60–74 year olds and colonoscopy to those with...http://www.medconnect.com.my/tabid/100/ct9/c459307/Colonoscopy-quality-measures-experience-from-the-NHS-Bowel-Cancer/Default.aspx18-May-2012 Background Non-alcoholic fatty liver disease is an obesity-related chronic liver disorder ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), which may progress to liver fibrosis and cirrhosis. Objective Tto investigate the role of Toll-like receptor (TLR) 4 in mediating the...http://www.medconnect.com.my/tabid/100/ct9/c459308/Toll-like-receptor-4-mediates-obesity-induced-non-alcoholic-steatohepatitis-through/Default.aspx18-May-2012 Objective It is difficult to predict the outcome in patients with acute liver failure (ALF) using existing prognostic models. This study investigated whether early changes in the levels of dynamic variables can predict outcome better than models based on static baseline variables. Design 380...http://www.medconnect.com.my/tabid/100/ct9/c459309/Prospective-derivation-and-validation-of-early-dynamic-model-for/Default.aspx18-May-2012 Background Hepatitis C virus (HCV) persistence is associated with impaired CD8 functions. Whether functional restoration of CD8 T cells chronically exposed to antigen can be obtained once the antigen is removed remains to be clarified. Objective To determine whether clearance of HCV by antiviral...http://www.medconnect.com.my/tabid/100/ct9/c459310/Lack-of-full-CD8-functional-restoration-after-antiviral-treatment/Default.aspx18-May-2012 Pancreatic cancer is a disease caused by the accumulation of genetic alterations in specific genes. Elucidation of the human genome sequence, in conjunction with technical advances in the ability to perform whole exome sequencing, have provided new insight into the mutational spectra...http://www.medconnect.com.my/tabid/100/ct9/c459311/Genetic-evolution-of-pancreatic-cancer-lessons-learnt-from-the/Default.aspx18-May-2012 We read with interest the paper from Muise et al in which they describe a rare variant in the NCF2 gene, which demonstrates a diminished RAC2 binding capacity.1 The NCF2 encoded protein p67phox is one of the components of the NADPH oxidase complex which drives the production of reactive oxygen...http://www.medconnect.com.my/tabid/100/ct9/c459312/Linking-risk-conferring-mutations-in-NCF4-to-functional-consequences/Default.aspx18-May-2012 We read with interest the article by Auernhammer and Göke1 on therapeutic strategies for liver metastasis in neuroendocrine carcinomas. Local tumour progress following radiofrequency ablation (RFA) occurred in only 6% of neuroendocrine carcinomas, but no data on overall survival and...http://www.medconnect.com.my/tabid/100/ct9/c459313/Percutaneous-cooled-tip-microwave-ablation-under-ultrasound-guidance-for-primary/Default.aspx18-May-2012 Research letter We read with interest the commentary by Bercik1 emphasising the influence that gut intestinal microflora may have on cognitive function—a model with clear therapeutic implications. We would like to propose, however, that a third party—the presence of autonomic nervous...http://www.medconnect.com.my/tabid/100/ct9/c459314/Cognitive-impairment-in-non-cirrhotic-chronic-liver-disease-is-unrelated/Default.aspx18-May-2012 We read with interest the article by Worthley et al1 regarding a new autosomal dominant syndrome characterised by fundic gland polyposis (FGP) and gastric cancer, which was not associated with familial adenomatous polyposis (FAP). We have experienced two similar cases of gastric adenocarcinoma...http://www.medconnect.com.my/tabid/100/ct9/c459315/Familial-fundic-gland-polyposis-with-gastric-cancer/Default.aspx18-May-2012When's the last time you treated yourself to a new mobile app? Okay, when's the last time you actually paid for an app? If you're like me, the answer was never. At least not until a few nights ago, when I sprang for an app called "Cholesterol Food Reference.” It lists...http://www.medconnect.com.my/tabid/100/ct9/c460895/Most-Users-Are-App-Freeloaders/Default.aspx18-May-2012Authors: Lucini D, Pagani M Abstract In this brief review we address schematically the relationship between two emerging issues in clinical medicine: stress and functional syndromes. It is becoming increasingly clear that they demand a multidimensional approach, considering simultaneously...http://www.medconnect.com.my/tabid/100/ct9/c460899/From-stress-to-functional-syndromes-An-internists-point-of-view-/Default.aspx18-May-2012[The Star] CAR and General have organised a free eye clinic at the Coast. The first will be held on Saturday at the Malindi District Hospital. The day-long exercise will be run in conjunction with the Lions Club of Mombasa and will start at 9am. This medical camp will cost the firm Sh250,000...http://www.medconnect.com.my/tabid/100/ct9/c460903/Kenya-Free-Eye-Clinic-Set-for-Malindi/Default.aspx17-May-2012The charity Médecins sans Frontières (MSF) has renewed calls for healthcare workers and medical facilities in Syria to be protected after it gained unauthorised entry to the country.The charity,... http://www.medconnect.com.my/tabid/100/ct9/c459425/Syrian-doctors-tell-charity-that-being-caught-with-patients/Default.aspx17-May-2012MERIDIAN, Idaho, May 17, 2012 (GLOBE NEWSWIRE) -- Healthy Habits Integrated Medicine of Meridian, Idaho, has announced a full range of physical medicine services to provide patients rehabilitation from a wide range of conditions and injuries. According the center, the physical medicine and...http://www.medconnect.com.my/tabid/100/ct9/c459697/Meridian-Chiropractor-Announces-Physical-Medicine-and-Rehabilitation-Services/Default.aspx17-May-2012The objective of this work was to investigate the effects of whole-body vibration on people with multiple sclerosis (MS). PubMed, CINAHL and Scopus databases were systematically searched for studies on the use of whole-body vibration (WBV) exercise in people with MS. These searches were...http://www.medconnect.com.my/tabid/100/ct9/c459699/Benefits-of-Whole-Body-Vibration-with-an-Oscillating-Platform-for/Default.aspx17-May-2012 Inflammation is the principal hallmark of RA. Different pathways are implicated in the production of pro-inflammatory cytokines, the bona fide mediators of this inflammation. Among them are the TNF pathway and the IL-1 receptor/Toll-like receptor (IL-1R/TLR4) pathway. One of the potential negative...http://www.medconnect.com.my/tabid/100/ct9/c459644/Fas-associated-death-domain-protein-and-adenosine-partnership-fad-in-RA/Default.aspx17-May-2012 The use of Doppler techniques, including power, colour and spectral Doppler, has greatly increased in rheumatology in recent years. This is due to the ability of Doppler US (DUS) to detect pathological vascularization within joints and periarticular soft tissues, thereby demonstrating the presence...http://www.medconnect.com.my/tabid/100/ct9/c459645/The-role-of-Doppler-ultrasound-in-rheumatic-diseases/Default.aspx17-May-2012 Objective. Behçet's disease is one of the major aetiologies of uveitis causing blindness in Asian countries. A genome-wide association study identified six microsatellite markers as disease susceptibility loci for Japanese patients with Behçet's disease. To confirm our recent...http://www.medconnect.com.my/tabid/100/ct9/c459646/Replication-of-a-microsatellite-genome-wide-association-study-of-Behcets/Default.aspx17-May-2012 Objective. Recent advances in molecular techniques have revealed that there is bi-directional transfer of cells between mother and child during pregnancy, and the presence of a mother's cells in her child has been termed maternal microchimerism (MMc). There is the potential for maternal cells to...http://www.medconnect.com.my/tabid/100/ct9/c459647/Maternal-microchimerism-in-muscle-biopsies-from-children-with-juvenile/Default.aspx17-May-2012 Objective. Evidence shows that defensins are involved in the pathogenesis of SLE and ANCA-associated small vasculitis (AASV). The copy number variation of DEFB4 has been proposed to be susceptible to inflammatory disorders. This study aims to investigate whether the DEFB4 genomic copy number...http://www.medconnect.com.my/tabid/100/ct9/c459648/Higher-DEFB4-genomic-copy-number-in-SLE-and-ANCA-associated-small-vasculitis/Default.aspx17-May-2012 Objective. To study the phenotypic characteristics of and the balance between systemic IL-7 receptor (IL-7R)α+ and IL-7Rα– Tregs in primary SS (pSS) patients as compared with control subjects and to assess the functional consequences this has for (IL-7-induced) T-cell...http://www.medconnect.com.my/tabid/100/ct9/c459650/IL-7-drives-Th1-and-Th17-cytokine-production-in-patients/Default.aspx17-May-2012 Objective. We explored the inhibitory effect of sulphoraphane (SFN), a potent inducer of Phase 2 enzymes, on cytokine-induced prostaglandin E2 (PGE2) and nitric oxide (NO) production and cartilage degradation in articular chondrocytes. The regulatory mechanism of SFN on nuclear factor (NF)-B was...http://www.medconnect.com.my/tabid/100/ct9/c459652/Phase-2-enzyme-inducer-sulphoraphane-blocks-prostaglandin-and-nitric/Default.aspx17-May-2012 Objective. SSc is known as the most severe connective tissue disorder, and to be associated with a high mortality risk. Some improvements in therapy for SSc have been achieved in recent years and some preliminary data have suggested an improvement in patient survival. Thus, we set out to determine...http://www.medconnect.com.my/tabid/100/ct9/c459653/Trends-in-mortality-in-patients-with-systemic-sclerosis-over/Default.aspx17-May-2012 Objectives. Internal organ involvement reduces the life expectancy of SSc patients. Cardiopulmonary manifestations are currently the primary cause of death. We aimed to perform a systematic review and meta-analysis to define more precise effect estimates of different cardiopulmonary manifestations...http://www.medconnect.com.my/tabid/100/ct9/c459655/The-impact-of-cardiopulmonary-manifestations-on-the-mortality-of/Default.aspx17-May-2012 Objective. Serum samples taken before the onset of RA suggest that one of the first features of RA is BMD loss. We determined the ability of radiographic BMD loss to predict RA development and arthritis persistency in patients with early undifferentiated arthritis (UA). Methods. Five hundred and...http://www.medconnect.com.my/tabid/100/ct9/c459656/Loss-of-metacarpal-bone-density-predicts-RA-development-in-recent-onset-arthritis/Default.aspx17-May-2012 Objective. Dysfunctional angiogenesis is a pathogenetic marker of SSc. Circulating levels of endothelial progenitor cells are reduced, and mesenchymal stromal cells show a reduced differentiation into endothelial cells and capacity to form capillaries. This suggests that pathophysiologically...http://www.medconnect.com.my/tabid/100/ct9/c459658/Evidence-for-reduced-angiogenesis-in-bone-marrow-in-SSc-/Default.aspx17-May-2012 Objective. To investigate the differential expression of MMP-1, tissue inhibitor of metalloproteinase-1 (TIMP-1) and hepatocyte growth factor (HGF) in clinically involved (affected) and uninvolved (unaffected) skin in patients with SSc. Methods. Punch biopsies from affected forearm and unaffected...http://www.medconnect.com.my/tabid/100/ct9/c459659/Differential-gene-expression-of-MMP-1-TIMP-1-and-HGF-in/Default.aspx17-May-2012 Objective. We have previously reported distinct symptom clusters among our patients with Behçet's syndrome (BS). The presence of such clusters suggests that more than one pathogenetic mechanism might be operative in BS. Increases in the frequency of certain clusters in familial BS cases, if...http://www.medconnect.com.my/tabid/100/ct9/c459661/The-papulopustular-lesion-arthritis-cluster-of-Behcets-syndrome-also-clusters/Default.aspx17-May-2012 Objectives. To describe the clinical, laboratory, histopathological presentations and final diagnoses for children presenting to a tertiary paediatric rheumatology service with an inflammatory lesion of the orbit. Methods. This was a retrospective descriptive case series of children with an...http://www.medconnect.com.my/tabid/100/ct9/c459663/Inflammatory-lesions-of-the-orbit-a-single-paediatric-rheumatology-centre-experience/Default.aspx17-May-2012 Objectives. The provisional ACR/European League Against Rheumatism (EULAR) definition of remission in RA requires a score of ≤1 on the patient global assessment (PGA, 0–10 scale). We explored the relation between the PGA criterion and the patient's clinical disease state in an...http://www.medconnect.com.my/tabid/100/ct9/c459664/The-provisional-ACR-EULAR-definition-of-remission-in-RA-a/Default.aspx17-May-2012 Objective. To test the diagnostic accuracy of modified American–European classification criteria (AEC) for primary SS (pSS) by replacing sialoscintigraphy (sSC) with ultrasonography of the major salivary glands. Methods. One hundred and ninety subjects were evaluated for the diagnosis of...http://www.medconnect.com.my/tabid/100/ct9/c459666/Ultrasonography-of-major-salivary-glands-could-be-an-alternative/Default.aspx17-May-2012 Objective. The autopsy and clinical information on children dying with anti-SSA/Ro-associated cardiac manifestations of neonatal lupus (cardiac NL) were examined to identify patterns of disease, gain insight into pathogenesis and enhance the search for biomarkers and preventive therapies. Methods....http://www.medconnect.com.my/tabid/100/ct9/c459667/Anatomical-and-pathological-findings-in-hearts-from-fetuses-and/Default.aspx17-May-2012 Objectives. To determine patterns on pain diagrams and corresponding diagnoses in patients referred to a rheumatology clinic and their sensitivity, specificity, and positive and negative predictive values (PPV and NPV, respectively). Methods. All new adult patient referrals from two...http://www.medconnect.com.my/tabid/100/ct9/c459669/The-sensitivity-and-specificity-of-pain-diagrams-in-rheumatic-disease-referrals/Default.aspx17-May-2012 Objective. Bone marrow oedema (BMO) and HLA-B27 are poor prognostic factors in axial SpA, and psoriasis is a poor prognostic factor in small-joint polyarthropathy. The aim of this study was to investigate the influence of HLA-B27, MRI BMO and psoriasis on long-term outcomes in early SpA-related...http://www.medconnect.com.my/tabid/100/ct9/c459670/Ten-year-follow-up-of-SpA-related-oligoarthritis-involving-the-knee-the/Default.aspx17-May-2012 Objective. The excess cardiac risk, found in RA has been attributed to biological inflammation. Effective control of inflammation may be of benefit in reducing cardiovascular risk in RA patients. The aim of this study is to investigate the effects of 24 and 52 weeks of rituximab treatment on...http://www.medconnect.com.my/tabid/100/ct9/c459671/No-significant-change-in-arterial-stiffness-in-RA-after/Default.aspx17-May-2012 Objective. The aim of the study was to assess the effect of long-term prednisolone on fasting and post-glucose load glucose concentration in patients with inflammatory rheumatological disease. We hypothesized that prednisolone would predominantly increase post-glucose load glucose concentration...http://www.medconnect.com.my/tabid/100/ct9/c459673/Screening-for-diabetes-in-patients-with-inflammatory-rheumatological-disease/Default.aspx17-May-2012 Objectives. To compare the prevalence of and predictors for sustained drug-free remission in two cohorts of patients with recent-onset RA treated with DAS-driven therapy or non-DAS-driven therapy. Methods. Sustained drug-free remission was assessed after 5 years of follow-up in 508 patients...http://www.medconnect.com.my/tabid/100/ct9/c459675/Sustained-drug-free-remission-in-rheumatoid-arthritis-after-DAS-driven-or/Default.aspx17-May-2012Conclusion Current guidelines recommend statins for people who have a 20% or greater chance of developing cardiovascular disease within 10 years. This large review of studies, which is a further assessment of previous research, suggests they may also benefit those without existing cardiovascular...http://www.medconnect.com.my/tabid/100/ct9/c460907/Statins-may-even-help-healthy-over-50s/Default.aspx17-May-2012Conclusion Current guidelines recommend statins for people who have a 20% or greater chance of developing cardiovascular disease within 10 years. This large review of studies, which further assessed previous research, suggests they may also benefit those without existing cardiovascular disease and...http://www.medconnect.com.my/tabid/100/ct9/c460911/Statins-may-help-even-healthy-over-50s/Default.aspx17-May-2012Do you love what you do? Most Americans don't. According to CareerFinders.com, four out of five Americans do not have their ideal jobs. The following are three factors that may help you identify your best career. read more (Source: Psychology Today Anxiety Center)http://www.medconnect.com.my/tabid/100/ct9/c459701/How-to-Find-Your-Best-Career-Get-Paid-Doing-What-You-Love/Default.aspx17-May-2012Those who are struggling to keep going to the gym should think about recruiting an exercise partner - as long as they are a little fitter than you, say scientists at Michigan State University. (Source: the Mail online | Health)http://www.medconnect.com.my/tabid/100/ct9/c459703/Finding-exercise-a-chore-How-a-virtual-partner-can-trick-you-into-working-harder/Default.aspx17-May-2012In March 2011 the most powerful earthquake and tsunami in Japan’s history caused horrifying devastation on the country’s northeastern coast. Along with a massive loss of life, the entire... http://www.medconnect.com.my/tabid/100/ct9/c459426/Can-Twitter-predict-disease-outbreaks-/Default.aspx17-May-2012Objective To estimate the degree of scatter of reports of randomised trials and systematic reviews, and how the scatter differs among medical specialties and subspecialties.Design Cross sectional... http://www.medconnect.com.my/tabid/100/ct9/c459427/The-scatter-of-research-cross-sectional-comparison-of-randomised/Default.aspx17-May-2012Peter Gøtzsche, having studied the science of mammography screening for a long time, is an angry man. And he has every reason to be. Like most public policy, that for mammography screening has... http://www.medconnect.com.my/tabid/100/ct9/c459428/How-we-got-it-wrong-with-breast-screening/Default.aspx17-May-2012An Indian parliamentary panel has said a “collusive nexus” between India’s drug regulators, manufacturers, and doctors has facilitated the irregular approvals of drugs and threatens to compromise the... http://www.medconnect.com.my/tabid/100/ct9/c459429/Indias-parliamentary-panel-sees-nexus-between-drug-regulators-manufacturers-/Default.aspx17-May-2012The European Parliament is refusing to sign off the European Medicines Agency’s financial accounts for 2010 until the London based organisation shows that it has effective procedures in place to... http://www.medconnect.com.my/tabid/100/ct9/c459430/Euro-MPs-refuse-to-approve-medicines-agencys-accounts-until/Default.aspx17-May-2012Conclusion This small study, carried out in highly artificial conditions, shows that students were able to judge sexuality with greater accuracy than could be put down to chance, and that women’s sexuality was judged more accurately than men’s sexuality. Despite these findings, the study should not...http://www.medconnect.com.my/tabid/100/ct9/c460915/A-glance-may-show-if-someone-is-gay/Default.aspx17-May-2012User-generated video content has grown tremendously fast to the point of outpacing professional content creation. In this work we develop methods that analyze contextual information of multiple user-generated videos in order to obtain semantic information about public happenings (e.g., sport and...http://www.medconnect.com.my/tabid/100/ct9/c459705/Multimodal-Semantics-Extraction-from-User-Generated-Videos/Default.aspx17-May-2012The most important market segmentation in sports and entertainment industry is the competition between customers that buy bundled and single tickets. A common selling practice is starting the selling season with bundled ticket sales and switching to selling single tickets later on. The aim of this...http://www.medconnect.com.my/tabid/100/ct9/c459707/Dynamically-Switching-among-Bundled-and-Single-Tickets-with-Time-Dependent/Default.aspx17-May-2012Updated Date: May 17, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))http://www.medconnect.com.my/tabid/100/ct9/c460919/PARROT-HEAD-FINS-UP-SPORT-15-MIST-SUNSCREEN-Avobenzone-Homosalate-Octisalate-/Default.aspx17-May-2012ConclusionsNon‐α‐adrenergic vasoconstriction was present during LBNP. The systemic vasoconstriction during static exercise and isolated muscle metaboreflex activation, in the absence of leg vasoconstriction, was explained by an α‐adrenergic mechanism. Therefore, non‐α‐adrenergic vasoconstriction is...http://www.medconnect.com.my/tabid/100/ct9/c460923/Non-alpha-adrenergic-effects-on-systemic-vascular-conductance-during-lower-body/Default.aspx17-May-2012Provision of dietary amino acids increases skeletal muscle protein synthesis (MPS), an effectthat is enhanced by prior resistance exercise. As a fundamentally necessary process in theenhancement of muscle mass, strategies to enhance rates of MPS would be beneficial in thedevelopment of...http://www.medconnect.com.my/tabid/100/ct9/c460927/Nutritional-regulation-of-muscle-protein-synthesis-with-resistance-exercise-/Default.aspx17-May-2012Conclusion.  The Dutch version of the nursing activity scale consists of 28 items and provides the opportunity to measure professional clinical autonomy for Dutch intensive care nurses using a well‐established method. (Source: Journal of Advanced Nursing)http://www.medconnect.com.my/tabid/100/ct9/c459709/Psychometric-properties-of-the-Dutch-version-of-the-American/Default.aspx17-May-2012Study finds endurance and 'game athletes' have higher tolerance for pain than the rest of us (Source: The Doctors Lounge - Health News)http://www.medconnect.com.my/tabid/100/ct9/c459711/Athletes-Really-Do-Play-Through-the-Pain/Default.aspx17-May-2012Conclusions: Classical CVD risk may influence endothelial function more than disease-related markers of inflammation in RA. Classical CVD risk factors and anti-TNFalpha medication have different effects on microvascular and macrovascular endothelial function, suggesting that combined CVD prevention...http://www.medconnect.com.my/tabid/100/ct9/c459687/The-role-of-Inflammation-Cardiovascular-Disease-Risk-on/Default.aspx17-May-2012IntroductionAnti-citrullinated peptide antibodies (ACPA) are found in rheumatoid arthritis (RA) patients with HLA-DR--chains encoding the shared epitope (SE) sequence. Citrullination can increase the immunogenicity of self-antigens, through increased binding affinity to SE-containing HLA-DR...http://www.medconnect.com.my/tabid/100/ct9/c459689/T-cell-autoreactivity-to-citrullinated-autoantigenic-peptides-in-rheumatoid-arthritis/Default.aspx17-May-2012The long term health and quality of life of patients with diabetes is being put at risk by the poor standard of care they receive in primary and secondary care, two reports have warned this... http://www.medconnect.com.my/tabid/100/ct9/c458643/Lack-of-specialist-diabetes-teams-in-hospitals-is-absolutely/Default.aspx17-May-2012Authors: Szmidt M Abstract Bronchodilators - long-acting b2-adrenergic agonists (formoterol and salmeterol) and a long-acting antimuscarinic drug (tiotropium), are the main drugs applied in symptomatic treatment of COPD. In patients with COPD, dyspnea is frequently associated with simple everyday...http://www.medconnect.com.my/tabid/100/ct9/c459136/-The-influence-of-treatment-with-formoterol-formoterol-with-tiotropium-/Default.aspx17-May-2012New England Journal of Medicine, Volume 366, Issue 20, Page 1849-1853, May 2012. http://www.medconnect.com.my/tabid/100/ct9/c459455/The-Evolving-Primary-Care-Physician/Default.aspx17-May-2012New England Journal of Medicine, Volume 366, Issue 20, Page 1905-1913, May 2012. http://www.medconnect.com.my/tabid/100/ct9/c459467/Somatic-STAT3-Mutations-in-Large-Granular-Lymphocytic-Leukemia/Default.aspx17-May-2012New England Journal of Medicine, Volume 366, Issue 20, Page 1914-1922, May 2012. http://www.medconnect.com.my/tabid/100/ct9/c459469/Secondary-Prevention-after-Ischemic-Stroke-or-Transient-Ischemic-Attack/Default.aspx17-May-2012New England Journal of Medicine, Volume 366, Issue 20, May 2012. http://www.medconnect.com.my/tabid/100/ct9/c459471/-Half-Half-Blisters/Default.aspx17-May-2012New England Journal of Medicine, Volume 366, Issue 20, Page 1924-1934, May 2012. http://www.medconnect.com.my/tabid/100/ct9/c459473/Case-15-2012/Default.aspx17-May-2012New England Journal of Medicine, Volume 366, Issue 20, Page 1853-1855, May 2012. http://www.medconnect.com.my/tabid/100/ct9/c459457/Mental-Illness-Comprehensive-Evaluation-or-Checklist-/Default.aspx17-May-2012New England Journal of Medicine, Volume 366, Issue 20, Page 1943-1944, May 2012. http://www.medconnect.com.my/tabid/100/ct9/c459479/Intramuscular-versus-Intravenous-Benzodiazepines-for-Status-Epilepticus/Default.aspx17-May-2012New England Journal of Medicine, Volume 366, Issue 20, Page 1940-1942, May 2012. http://www.medconnect.com.my/tabid/100/ct9/c459477/Stem-Cells-and-Spinal-Cord-Repair/Default.aspx17-May-2012New England Journal of Medicine, Volume 366, Issue 20, Page 1855-1857, May 2012. http://www.medconnect.com.my/tabid/100/ct9/c459459/Grief-Depression-and-the-DSM-5/Default.aspx17-May-2012New England Journal of Medicine, Volume 366, Issue 20, Page 1870-1880, May 2012. http://www.medconnect.com.my/tabid/100/ct9/c459461/Risk-of-Natalizumab-Associated-Progressive-Multifocal-Leukoencephalopathy/Default.aspx17-May-2012New England Journal of Medicine, Volume 366, Issue 20, Page 1881-1890, May 2012. http://www.medconnect.com.my/tabid/100/ct9/c459463/Azithromycin-and-the-Risk-of-Cardiovascular-Death/Default.aspx17-May-2012New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print. http://www.medconnect.com.my/tabid/100/ct9/c459449/Lost-in-Translation-¿Como-se-dice-Patient-Protection-and-Affordable-Care-Act-/Default.aspx17-May-2012New England Journal of Medicine, Volume 366, Issue 20, Page 1891-1904, May 2012. http://www.medconnect.com.my/tabid/100/ct9/c459465/Association-of-Coffee-Drinking-with-Total-and-Cause-Specific-Mortality/Default.aspx17-May-2012New England Journal of Medicine, Volume 366, Issue 20, Page 1938-1939, May 2012. http://www.medconnect.com.my/tabid/100/ct9/c459475/Predicting-Risk-of-Progressive-Multifocal-Leukoencephalopathy-from-Natalizumab/Default.aspx17-May-2012New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print. http://www.medconnect.com.my/tabid/100/ct9/c459453/Regulatory-Review-of-Novel-Therapeutics-Comparison-of-Three-Regulatory-Agencies/Default.aspx17-May-2012New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print. http://www.medconnect.com.my/tabid/100/ct9/c459451/Emergency-Departments-Medicaid-Costs-and-Access-to-Primary-Care-/Default.aspx17-May-2012 Objective— At sites of vascular injury, thrombin is an important mediator in thrombus growth and stability. Using microfluidic flow devices as well as patterned surfaces of collagen and tissue factor (TF), we sought to determine the role that fibrin plays in clot stability without...http://www.medconnect.com.my/tabid/100/ct9/c458407/Thrombus-Growth-and-Embolism-on-Tissue-Factor-Bearing-Collagen-Surfaces/Default.aspx17-May-2012 Objective— Thrombin induces CD40 ligand (CD40L) and matrix metalloproteinases (MMPs) under inflammatory/prothrombotic conditions. Thrombin and CD40L could modulate endothelial MMP-10 expression in vitro and in vivo. Methods and Results— Human endothelial cells were stimulated with...http://www.medconnect.com.my/tabid/100/ct9/c458409/Synergistic-Effect-of-Thrombin-and-CD40-Ligand-on-Endothelial/Default.aspx17-May-2012 Objectives— To define the mechanism of p47phox phosphorylation in regulating endothelial cell response to tumor necrosis factor-α (TNFα) stimulation. Methods and Results— We replaced 11 serines (303-4, 310, 315, 320, 328, 345, 348, 359, 370, and 379) with alanines and...http://www.medconnect.com.my/tabid/100/ct9/c458412/Divergent-Effects-of-p47phox-Phosphorylation-at-S303-4-or-S379/Default.aspx17-May-2012 Objective— Serum osteoprotegerin (OPG) concentrations have previously been associated with growth of abdominal aortic aneurysms (AAAs). In vitro experiments showed that OPG promotes matrix metalloprotease (MMP) release from monocytes and vascular smooth muscle cells. We hypothesized that OPG...http://www.medconnect.com.my/tabid/100/ct9/c458414/Osteoprotegerin-Is-Associated-With-Aneurysm-Diameter-and-Proteolysis-in/Default.aspx17-May-2012 Objectives— To determine whether the level of lysophosphatidylcholine (lysoPC) generated by lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with severity of inflammation in human atherosclerotic plaques. Elevated plasma Lp-PLA2 is associated with increased cardiovascular...http://www.medconnect.com.my/tabid/100/ct9/c458417/Evidence-Supporting-a-Key-Role-of-Lp-PLA2-Generated-Lysophosphatidylcholine-in/Default.aspx17-May-2012 Objectives— Incretin-based therapies for the treatment of type 2 diabetes mellitus improve plasma lipid profiles and postprandial lipemia, but their exact mechanism of action remains unclear. Here, we examined the acute effect of the glucagon-like peptide-1 receptor agonist, exenatide, on...http://www.medconnect.com.my/tabid/100/ct9/c458420/Exenatide-a-Glucagon-like-Peptide-1-Receptor-Agonist-Acutely-Inhibits-Intestinal/Default.aspx17-May-2012 Objective— Anderson disease is a rare inherited lipid malabsorption syndrome associated with hypocholesterolemia and linked to SAR1B mutations. The aim of this article was to analyze the mechanisms responsible for the low plasma apolipoprotein Apo-B100 and Apo-AI in 2 patients with Anderson...http://www.medconnect.com.my/tabid/100/ct9/c458422/Low-Rate-of-Production-of-Apolipoproteins-B100-and-AI/Default.aspx17-May-2012 Objective — Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that influences plasma low-density lipoprotein concentration and susceptibility to coronary heart disease. Circulating PCSK9 levels show considerable interindividual differences, but the factors...http://www.medconnect.com.my/tabid/100/ct9/c458425/Common-and-Low-Frequency-Genetic-Variants-in-the-PCSK9-Locus/Default.aspx17-May-2012 Objective— Genetic studies implicated upstream stimulatory factor 1 (USF1) in familial combined hyperlipidemia because the rs2073658 minor allele was associated with reduced risk of familial combined hyperlipidemia and related disorders. The molecular mechanisms whereby rs2073658 influences...http://www.medconnect.com.my/tabid/100/ct9/c458426/Potential-Role-of-Upstream-Stimulatory-Factor-1-Gene-Variant/Default.aspx17-May-2012 Objective— Acute ischemic events are often caused by the disruption of lipid-rich plaques, which are frequently not angiographically visible. Vascular cell adhesion molecule-1 and apoptotic cell-targeted peptides studied during our previous work were conjugated to ultrasmall...http://www.medconnect.com.my/tabid/100/ct9/c458359/Development-of-a-Magnetic-Resonance-Imaging-Protocol-for-the/Default.aspx17-May-2012 In this short review, we discuss apolipoprotein B100 and the assembly of very low-density lipoproteins. In particular, we address the nature and importance of co- and posttranslational degradation of apolipoprotein B100 during the assembly process. We also provide a short historical background to...http://www.medconnect.com.my/tabid/100/ct9/c458362/Apolipoprotein-B-Secretory-Regulation-by-Degradation-History-of-Discovery-/Default.aspx17-May-2012 Although already evident from the earliest days of macrophage research, the diversity of macrophage distribution, morphology, and function continues to attract immunologists interested in their role in physiology and disease. Contemporary tools of cellular and molecular analysis have begun to...http://www.medconnect.com.my/tabid/100/ct9/c458365/Macrophage-Heterogeneity-A-Personal-Scientific-Journey-History-of-Discovery-/Default.aspx17-May-2012 The asymmetric methylarginines inhibit nitric oxide synthesis in vivo by competing with L-arginine at the active site of nitric oxide synthase. High circulating levels of asymmetric dimethylarginine predict adverse outcomes, specifically vascular events but there is now increasing experimental and...http://www.medconnect.com.my/tabid/100/ct9/c458368/Endogenous-Nitric-Oxide-Synthase-Inhibitors-in-the-Biology-of/Default.aspx17-May-2012 Objective— Pulmonary arterial hypertension is a progressive pulmonary vascular disorder with high morbidity and mortality. Compelling evidence suggests that receptor tyrosine kinases, such as platelet-derived growth factor (PDGF) are closely involved in the pathogenesis of pulmonary arterial...http://www.medconnect.com.my/tabid/100/ct9/c458371/Role-of-Src-Tyrosine-Kinases-in-Experimental-Pulmonary-Hypertension/Default.aspx17-May-2012 Objectives— Toxicity of intense light to facilitate the development of neovascular age-related macular degeneration has been a health concern although the mechanism remains unclear. Methods and Results— Effects of intense, but within physiological range, light on retinal pigment...http://www.medconnect.com.my/tabid/100/ct9/c458374/Intense-Physiological-Light-Upregulates-Vascular-Endothelial-Growth-Factor-and/Default.aspx17-May-2012 Objective— MicroRNAs (miRs) regulate angiogenesis by posttranscriptional silencing of target genes. The significance of angiostatic miR-200b in switching on skin wound angiogenesis was tested. Methods and Results— Wounding caused imminent and transient downregulation of miR-200b in...http://www.medconnect.com.my/tabid/100/ct9/c458377/Downregulation-of-Endothelial-MicroRNA-200b-Supports-Cutaneous-Wound-Angiogenesis-By/Default.aspx17-May-2012 Objective— Previous findings from our laboratory demonstrated that neovascularization was impaired in osteopontin (OPN) knockout animals. However, the mechanisms responsible for the regulation of OPN expression in the setting of ischemia remain undefined. Therefore, we sought to determine...http://www.medconnect.com.my/tabid/100/ct9/c458380/Reactive-Oxygen-Species-Regulate-Osteopontin-Expression-in-a-Murine/Default.aspx17-May-2012 Objectives— Obesity promotes hypertension, but it is unclear if sex differences exist in obesity-related hypertension. Angiotensin converting enzyme 2 (ACE2) converts angiotensin II (AngII) to angiotensin-(1–7) (Ang-[1–7]), controlling peptide balance. We hypothesized that...http://www.medconnect.com.my/tabid/100/ct9/c458383/Angiotensin-Converting-Enzyme-2-Contributes-to-Sex-Differences-in/Default.aspx17-May-2012 Objective— Recently, we reported that angiopoietin-like protein 2 (Angptl2) functions in various chronic inflammatory diseases. In the present study, we asked whether Angptl2 and its associated chronic inflammation contribute to abdominal aortic aneurysm (AAA). Methods and...http://www.medconnect.com.my/tabid/100/ct9/c458386/Macrophage-Derived-Angiopoietin-Like-Protein-2-Accelerates-Development-of-Abdominal/Default.aspx17-May-2012 Objective— The mechanisms underlying abdominal aortic aneurysm development remain unknown. We hypothesized that acceleration of glucose metabolism with the upregulation of glucose transporters is associated with abdominal aortic aneurysm development. Methods and Results— Enhanced...http://www.medconnect.com.my/tabid/100/ct9/c458388/Inhibition-of-Development-of-Abdominal-Aortic-Aneurysm-by-Glycolysis/Default.aspx17-May-2012 Objective— Low and nontoxic proteasome inhibition has anti-inflammatory, antiproliferative, and antioxidative effects on vascular cells in vitro and in vivo. We hypothesized that low-dose inhibition of the proteasome could provide antiatherogenic protection. The present study investigated...http://www.medconnect.com.my/tabid/100/ct9/c458391/Attenuation-of-Early-Atherogenesis-in-Low-Density-Lipoprotein-Receptor-Deficient-Mice/Default.aspx17-May-2012 Objective— Endothelial cell activation is an important mediator of monocyte recruitment to sites of vascular inflammation. We hypothesized that high-affinity dual-ligand microparticles of iron oxide (MPIO), targeted to P-selectin and vascular cell adhesion molecule-1 (PV-MPIO), would...http://www.medconnect.com.my/tabid/100/ct9/c458393/A-Leukocyte-Mimetic-Magnetic-Resonance-Imaging-Contrast-Agent-Homes-Rapidly/Default.aspx17-May-2012 Objective— The dominant-negative mutation, P467L, in peroxisome proliferator–activated receptor- (PPAR) affects adipose tissue distribution, insulin sensitivity, and blood pressure in heterozygous humans. We hypothesized that the equivalent mutation, PPAR-P465L, in mice will worsen...http://www.medconnect.com.my/tabid/100/ct9/c458396/Pro-and-Antiatherogenic-Effects-of-a-Dominant-Negative-P465L-Mutation/Default.aspx17-May-2012 Objective— Oxidative stress is believed to play a key role in cardiovascular disorders. Thioredoxin (Trx) is an oxidative stress-limiting protein with anti-inflammatory and antiapoptotic properties. Here, we analyzed whether Trx-1 might exert atheroprotective effects by promoting macrophage...http://www.medconnect.com.my/tabid/100/ct9/c458399/Thioredoxin-1-Promotes-Anti-Inflammatory-Macrophages-of-the-M2-Phenotype-and/Default.aspx17-May-2012 Objective— Angiotensin II is involved in the genesis of atherosclerosis. As the role of the angiotensin II type 1a (AT1a) receptor in plaque rupture is poorly understood, we assessed the hypothesis that the AT1areceptor contributes to atherosclerotic plaque rupture. Methods and...http://www.medconnect.com.my/tabid/100/ct9/c458401/Deletion-of-the-Angiotensin-II-Type-1a-Receptor-Prevents/Default.aspx17-May-2012 Objective— Reverse cholesterol transport (RCT) involves the removal of cholesterol from peripheral tissue for excretion in the feces. Here, we determined whether red blood cells (RBCs) can contribute to RCT. Methods and Results— We performed a series of studies in apolipoprotein...http://www.medconnect.com.my/tabid/100/ct9/c458404/Red-Blood-Cells-Play-a-Role-in-Reverse-Cholesterol/Default.aspx17-May-2012 Initial antihypertensive therapy with single-pill combinations produced more rapid blood pressure control than initial monotherapy in clinical trials. Other studies reported better cardiovascular outcomes in patients achieving lower blood pressure during the first treatment year. We assessed the...http://www.medconnect.com.my/tabid/100/ct9/c458300/Initial-Monotherapy-and-Combination-Therapy-and-Hypertension-Control-the/Default.aspx17-May-2012 Day-by-day home blood pressure (BP) variability (BPV) was reported to be associated with increased cardiovascular risk. We aimed to test the hypothesis that the angiotensin II receptor blocker/calcium-channel blocker combination decreases day-by-day BPV more than the angiotensin II receptor...http://www.medconnect.com.my/tabid/100/ct9/c458302/Combined-Effect-of-Angiotensin-II-Receptor-Blocker-and-Either/Default.aspx17-May-2012 Carbon monoxide (CO) is a physiological messenger with diverse functions in the kidney, including controlling afferent arteriole tone both directly and via tubuloglomerular feedback (TGF). We have reported that CO attenuates TGF, but the mechanisms underlying this effect remain unknown. We...http://www.medconnect.com.my/tabid/100/ct9/c458303/Mechanisms-of-Carbon-Monoxide-Attenuation-of-Tubuloglomerular-Feedback-Kidney-/Default.aspx17-May-2012 Inappropriate Na+ reabsorption by thick ascending limbs (THALs) induces hypertension. NO produced by NO synthase type 3 (NOS3) inhibits NaCl reabsorption by THALs. Tumor necrosis factor α (TNF-α) decreases NOS3 expression in endothelial cells and contributes to increases in blood...http://www.medconnect.com.my/tabid/100/ct9/c458305/Tumor-Necrosis-Factor-{alpha}-Decreases-Nitric-Oxide-Synthase-Type/Default.aspx17-May-2012 The circadian clock protein period 1 (Per1) contributes to the regulation of expression of the α subunit of the renal epithelial sodium channel at the basal level and in response to the mineralocorticoid hormone aldosterone. The goals of the present study were to define the role of Per1 in...http://www.medconnect.com.my/tabid/100/ct9/c458307/The-Circadian-Protein-Period-1-Contributes-to-Blood-Pressure-Control/Default.aspx17-May-2012 Nighttime blood pressure (BP) dipping can be quantified as the ratio of mean nighttime (sleep) BP to mean daytime (awake) BP. People whose dipping ratio is ≥0.90 have been referred to as nondippers, and nondipping is associated with cardiovascular disease events. We examined the relationship...http://www.medconnect.com.my/tabid/100/ct9/c458308/Nighttime-Blood-Pressure-Dipping-in-Young-Adults-and-Coronary/Default.aspx17-May-2012 Low-dose mineralocorticoid receptor antagonists reduce morbidity and mortality in patients with heart failure and myocardial infarction, despite normal plasma aldosterone levels. Since apoptosis plays an important role in heart failure and postinfarction left ventricular remodeling, we examined...http://www.medconnect.com.my/tabid/100/ct9/c458309/Low-Dose-Spironolactone-Prevents-Apoptosis-Repressor-With-Caspase-Recruitment-Domain/Default.aspx17-May-2012 Chronic left ventricular failure causes pulmonary congestion with increased lung weight and type 2 pulmonary hypertension. Understanding the molecular mechanisms for type 2 pulmonary hypertension and the development of novel treatments for this condition requires a robust experimental animal model...http://www.medconnect.com.my/tabid/100/ct9/c458311/Left-Ventricular-Failure-Produces-Profound-Lung-Remodeling-and-Pulmonary-Hypertension/Default.aspx17-May-2012 The renin-angiotensin-aldosterone system is involved in the arterial hypertension-associated cardiovascular remodeling. In this context, the development of cardiac fibrosis results from an imbalance between profibrotic and antifibrotic pathways, in which the role of aldosterone is yet not...http://www.medconnect.com.my/tabid/100/ct9/c458312/Aldosterone-Inhibits-Antifibrotic-Factors-in-Mouse-Hypertensive-Heart-Heart-/Default.aspx17-May-2012 The (pro)renin receptor is a newly discovered member of the brain renin-angiotensin system. To investigate the role of brain (pro)renin receptor in hypertension, adeno-associated virus-mediated (pro)renin receptor short hairpin RNA was used to knockdown (pro)renin receptor expression in the brain...http://www.medconnect.com.my/tabid/100/ct9/c458314/Brain-Targeted-Pro-renin-Receptor-Knockdown-Attenuates-Angiotensin-II-Dependent/Default.aspx17-May-2012 Loss of angiotensin (Ang)-converting enzyme 2 (ACE2) and inability to metabolize Ang II to Ang 1-7 perpetuate the actions of Ang II after biomechanical stress and exacerbate early adverse myocardial remodeling. Ang receptor blockers are known to antagonize the effect of Ang II by blocking Ang II...http://www.medconnect.com.my/tabid/100/ct9/c458316/Cardioprotective-Effects-Mediated-by-Angiotensin-II-Type-1-Receptor/Default.aspx17-May-2012 A single-nucleotide polymorphism (C/A) located within an E-box at the –20 position of the human angiotensinogen (AGT) promoter may regulate transcriptional activation through differential recruitment of the transcription factors upstream stimulatory factor (USF) 1 and 2. To study the...http://www.medconnect.com.my/tabid/100/ct9/c458319/Gene-Trapping-Uncovers-Sex-Specific-Mechanisms-for-Upstream-Stimulatory-Factors-1/Default.aspx17-May-2012 Family history of hypertension increases the risk of an individual to develop hypertension, whereas moderate-to-high cardiorespiratory fitness has the opposite effect. However, the joint association of each on the development of hypertension is not well understood. We studied fitness and incident...http://www.medconnect.com.my/tabid/100/ct9/c458322/Cardiorespiratory-Fitness-Reduces-the-Risk-of-Incident-Hypertension-Associated-With/Default.aspx17-May-2012 Aging is associated with dysfunction of endothelial progenitor cells (EPCs), and shear stress has a beneficial impact on EPC function; however, the effects of aging and shear stress on the endothelial repair capacity of EPCs after arterial injury have not been reported. Here we investigated the...http://www.medconnect.com.my/tabid/100/ct9/c458324/Age-Related-Decline-in-Reendothelialization-Capacity-of-Human-Endothelial-Progenitor/Default.aspx17-May-2012 The goal of the study was to assess whether pulsatile atheroprone shear stress modulates the expression of transient receptor potential (TRP) channels, TRPC3, TRPC6, TRPM7, and TRPV1 mRNA, in human umbilical vascular endothelial cells. Exposure of cultured vascular endothelial cells to defined...http://www.medconnect.com.my/tabid/100/ct9/c458327/Pulsatile-Atheroprone-Shear-Stress-Affects-the-Expression-of-Transient/Default.aspx17-May-2012 We compared patterns of blood pressure (BP) change among normotensive women, women who developed gestational hypertension or preeclampsia, and women who had essential hypertension to examine how distinct these conditions are and whether rates of BP change may help to identify women at risk for...http://www.medconnect.com.my/tabid/100/ct9/c458332/Blood-Pressure-Change-in-Normotensive-Gestational-Hypertensive-Preeclamptic-and/Default.aspx17-May-2012 Preeclampsia is characterized by increased thromboxane and decreased prostacyclin levels, which predate symptoms, and can explain some of the clinical manifestations of preeclampsia, including hypertension and thrombosis. In this study, we examined DNA methylation of the promoter region of the...http://www.medconnect.com.my/tabid/100/ct9/c458334/Reduced-Methylation-of-the-Thromboxane-Synthase-Gene-Is-Correlated-With/Default.aspx17-May-2012 Some small molecular weight peptides possess potent vasoactive properties. Herein we have identified the laminin nonapeptide (LNP) CDPGYIGSR as a novel vasoconstrictive agent. Isometric force measurements revealed that LNP induced vasoconstriction in small and large murine arteries in a...http://www.medconnect.com.my/tabid/100/ct9/c458341/Identification-of-a-Novel-Vasoconstrictor-Peptide-Specific-for-the/Default.aspx17-May-2012 Testosterone has been implicated in vascular remodeling associated with hypertension. Molecular mechanisms underlying this are elusive, but oxidative stress may be important. We hypothesized that testosterone stimulates generation of reactive oxygen species (ROS) and migration of vascular smooth...http://www.medconnect.com.my/tabid/100/ct9/c458344/Testosterone-Induces-Vascular-Smooth-Muscle-Cell-Migration-by-NADPH/Default.aspx17-May-2012 Hydrochlorothiazide (HCTZ) is widely used for hypertension, and prescriptions for HCTZ outnumber those for chlorthalidone (CTDN) by >20-fold in 2 recent surveys. Some have recently expressed a preference for CTDN. However, head-to-head trials testing the effect of the 2 drugs on cardiovascular...http://www.medconnect.com.my/tabid/100/ct9/c458296/Chlorthalidone-Compared-With-Hydrochlorothiazide-in-Reducing-Cardiovascular-Events-/Default.aspx17-May-2012 The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure defined blood pressure (BP) levels of 120 to 139/80 to 89 mm Hg as prehypertension and those of ≥140/90 mm Hg as hypertension. Hypertension can be divided into 3...http://www.medconnect.com.my/tabid/100/ct9/c458298/Effects-of-Prehypertension-and-Hypertension-Subtype-on-Cardiovascular-Disease/Default.aspx17-May-2012A new study suggests that head impacts experienced during contact sports such as football and hockey may worsen some college athletes' ability to acquire new information. (Source: American Academy of Neurology)http://www.medconnect.com.my/tabid/100/ct9/c459137/Study-Finds-Head-Impacts-in-Contact-Sports-May-Reduce-Learning-in-College-Athletes/Default.aspx17-May-2012The study goals were to (1) establish the variability in postprandial glucose control in healthy young people consuming a mixed meal and, then (2) determine the acute and residual impact of a single exercise bout on postprandial glucose control. In study 1, 18 people completed two similar mixed...http://www.medconnect.com.my/tabid/100/ct9/c459138/The-Acute-and-Residual-Effect-of-a-Single-Exercise/Default.aspx17-May-2012 Aims The myocardium accumulates intracellular lipids under ischaemic conditions, and myocardial fat deposition is closely associated with cardiac dysfunction. Our aims were to analyse the effect of hypoxia on low-density lipoprotein receptor-related protein 1 (LRP1) expression in neonatal rat...http://www.medconnect.com.my/tabid/100/ct9/c458455/Low-density-lipoprotein-receptor-related-protein-1-mediates-hypoxia-induced-very-low/Default.aspx17-May-2012 Aims Binge drinking often triggers compromised myocardial contractile function while activating AMP-activated protein kinase (AMPK). Given the role of AMPK in the initiation of autophagy through the mammalian target of rapamycin complex 1 (mTORC1) and Unc51-like kinase (ULK1), this study was...http://www.medconnect.com.my/tabid/100/ct9/c458458/Deficiency-in-AMPK-attenuates-ethanol-induced-cardiac-contractile-dysfunction-through/Default.aspx17-May-2012 Aims P27Kip1 (p27) blocks cell proliferation through the inhibition of cyclin-dependent kinase 2 (cdk-2). Despite robust expression in the heart, little is known about the regulation and function of p27 in this terminally differentiated tissue. Previously, we demonstrated that p27 exerts...http://www.medconnect.com.my/tabid/100/ct9/c458460/Post-myocardial-infarct-p27-fusion-protein-intravenous-delivery-averts-adverse/Default.aspx17-May-2012 Aims The effectiveness of postconditioning (POC) in hypercholesterolaemia is in dispute. We investigated the effects of 3-day lipophilc (simvastatin) or hydrophilic (pravastatin) statin treatment, without or with POC in normocholesterolaemic (Norm) and hypercholesterolaemic (Chol)...http://www.medconnect.com.my/tabid/100/ct9/c458464/Short-term-statin-administration-in-hypercholesterolaemic-rabbits-resistant-to/Default.aspx17-May-2012 Aims Adequate endothelial cell stimulation is a prerequisite for the adaptive remodelling of macro- and microvessels. A pivotal autocrine mechanism following endothelial cell activation is the release of angiopoietin-2 (Ang-2), which subsequently antagonizes the binding of Ang-1 to the Tie-2...http://www.medconnect.com.my/tabid/100/ct9/c458466/Angiopoietin-1-mediates-inhibition-of-hypertension-induced-release-of-angiopoietin-2/Default.aspx17-May-2012 Aims Circulating angiogenic cells (CAC) participate in cardiac repair. CAC recruitment to the ischaemic heart is mainly induced by the chemokine (C–X–C motif) receptor 4 (CXCR4)/stromal-cell derived factor-1α axis. However, CAC mobilization is only partly prevented by CXCR4...http://www.medconnect.com.my/tabid/100/ct9/c458469/Monocyte-chemotactic-protein-3-is-a-homing-factor-for-circulating-angiogenic-cells/Default.aspx17-May-2012 Aims Platelet adhesion and aggregation is essential for haemostasis and thrombosis. Cytoskeletal reorganization of activated platelets plays a crucial role in these processes and implies activation of Rho GTPases. Rho GTPases are regulated by GTPase-activating proteins (GAPs) that stimulate GTP...http://www.medconnect.com.my/tabid/100/ct9/c458472/The-GRAF-family-member-oligophrenin1-is-a-RhoGAP-with/Default.aspx17-May-2012 Aims Microparticles are membrane vesicles shed by cells upon activation and/or apoptosis. Microparticles are involved in several processes, including blood coagulation and thrombosis. In addition to their role in the regulation of lipid metabolism, peroxisome proliferator-activated receptor-...http://www.medconnect.com.my/tabid/100/ct9/c458476/Effects-of-peroxisome-proliferator-activated-receptor-{gamma}-agonists-on-the/Default.aspx17-May-2012 Aims Vascular cartilaginous metaplasia and calcification are common in patients with atherosclerosis. However, sources of cells contributing to the development of this complication are currently unknown. In this study, we ascertained the origin of cells that give rise to cartilaginous and bony...http://www.medconnect.com.my/tabid/100/ct9/c458480/Sources-of-cells-that-contribute-to-atherosclerotic-intimal-calcification-an/Default.aspx17-May-2012 We review the pivotal role of the stromal derived factor (SDF)-1 chemokine in tissue ischaemia and how it orchestrates the rapid revascularization of injured, ischaemic, and regenerating tissues via the CXC chemokine receptors CXCR4 and CXCR7. Furthermore, we discuss the effects of preconditioning...http://www.medconnect.com.my/tabid/100/ct9/c458435/The-SDF-1-CXCR4-axis-in-stem-cell-preconditioning/Default.aspx17-May-2012 Aims The optic atrophy 1 (OPA1) protein is an essential protein involved in the fusion of the mitochondrial inner membrane. Despite its high level of expression, the role of OPA1 in the heart is largely unknown. We investigated the role of this protein in Opa1+/– mice, having a 50% reduction...http://www.medconnect.com.my/tabid/100/ct9/c458438/Down-regulation-of-OPA1-alters-mouse-mitochondrial-morphology-PTP-function-/Default.aspx17-May-2012 Aims The factors responsible for cardiomyopathy are not fully understood. Our studies of the transcriptome of human embryonic stem cell-derived cardiomyocytes identified novel genes up-regulated during cardiac differentiation, including RBM24. We therefore studied how its deficiency affected heart...http://www.medconnect.com.my/tabid/100/ct9/c458440/RNA-binding-protein-RBM24-is-required-for-sarcomere-assembly-and-heart-contractility/Default.aspx17-May-2012 Aims The aim of the present study was to assess whether the addition of a nitric oxide (NO)-donating moiety to atorvastatin enhances anti-inflammatory and anti-atherogenic effects in an animal model of endothelial dysfunction, systemic peroxidation and inflammation, and accelerated...http://www.medconnect.com.my/tabid/100/ct9/c458443/Nitric-oxide-enhances-the-anti-inflammatory-and-anti-atherogenic-activity-of/Default.aspx17-May-2012 Aim Treatment of disorders of the sinus node or the atrioventricular node requires insights into the molecular mechanisms of development and homoeostasis of these pacemaker tissues. In the developing heart, transcription factor TBX3 is required for pacemaker and conduction system development....http://www.medconnect.com.my/tabid/100/ct9/c458445/T-box-transcription-factor-TBX3-reprogrammes-mature-cardiac-myocytes-into/Default.aspx17-May-2012 Aims Reentry accounts for most life-threatening arrhythmias, complicating myocardial infarction, and therapies that consistently prevent reentry from occurring are lacking. In this study, we compare antiarrhythmic effects of gene transfer of green fluorescent protein (GFP; sham), the skeletal...http://www.medconnect.com.my/tabid/100/ct9/c458448/SkM1-and-Cx32-improve-conduction-in-canine-myocardial-infarcts/Default.aspx17-May-2012 Aims Cardiolipin (CL) is a tetra-acyl phospholipid that provides structural and functional support to several proteins in the inner mitochondrial membrane. The majority of CL in the healthy mammalian heart contains four linoleic acid acyl chains (L4CL). A selective loss of L4CL is associated with...http://www.medconnect.com.my/tabid/100/ct9/c458451/Dietary-linoleate-preserves-cardiolipin-and-attenuates-mitochondrial-dysfunction-in/Default.aspx17-May-2012 Background There are few data comparing the onset time of interscalene brachial plexus block performed using ultrasound (US) guidance or nerve stimulation (NS) technique for elective coracoacromial ligament repair. Methods Fifty ASA I–III patients were randomly allocated to receive a...http://www.medconnect.com.my/tabid/100/ct9/c459084/Prospective-randomized-comparison-of-ultrasound-guided-and-neurostimulation/Default.aspx17-May-2012 Background Intubation is one of the most important anaesthetic skills. We developed a robotic intubation system (Kepler intubation system, KIS) for oral tracheal intubation. Methods In this pilot study, 12 patients were enrolled after approval of the local Ethics board and written informed...http://www.medconnect.com.my/tabid/100/ct9/c459085/First-robotic-tracheal-intubations-in-humans-using-the-Kepler-intubation-system/Default.aspx17-May-2012 Background A small, flow-regulated, manually operated ventilator designed for ventilation through a narrow-bore transtracheal catheter (TTC) has become available (Ventrain, Dolphys Medical BV, Eindhoven, The Netherlands). It is driven by a predetermined flow of oxygen from a high-pressure source...http://www.medconnect.com.my/tabid/100/ct9/c459086/Ventrain-an-ejector-ventilator-for-emergency-use/Default.aspx17-May-2012 Background It is no longer safe to use large tidal volumes (VT) (>8 ml kg–1) for one-lung ventilation (OLV), and limiting plateau pressure should be a major objective. Due to the specificity of OLV, the use of positive end-expiratory pressure (PEEP) remains controversial. This study...http://www.medconnect.com.my/tabid/100/ct9/c459087/Reducing-tidal-volume-and-increasing-positive-end-expiratory-pressure-with/Default.aspx17-May-2012 Background The relative respiratory effects of fentanyl and remifentanil, administered as i.v. bolus, have not previously been studied. We determined what remifentanil bolus dose gave the same maximum depression of ventilation as 1 µg kg–1 of fentanyl. Methods Twelve healthy...http://www.medconnect.com.my/tabid/100/ct9/c459088/Intravenous-boluses-of-fentanyl-1-{micro}g-kg-1-and-remifentanil-/Default.aspx17-May-2012 Hypovolaemia after overnight fasting is believed to exacerbate postoperative nausea and vomiting (PONV). However, data on the efficacy of supplemental i.v. crystalloids for PONV prophylaxis are conflicting. We performed a literature search using CENTRAL, MEDLINE, EMBASE, CINAHL, and Web of...http://www.medconnect.com.my/tabid/100/ct9/c459072/Supplemental-intravenous-crystalloids-for-the-prevention-of-postoperative-nausea/Default.aspx17-May-2012 Local anaesthetic (LA) agents have been routinely used in dentistry, ophthalmology, minor surgery, and obstetrics since the late nineteenth century. Reports relating to adverse reactions and LA allergy have appeared in the published literature for several years. However, the incidence of true,...http://www.medconnect.com.my/tabid/100/ct9/c459073/IgE-mediated-allergy-to-local-anaesthetics-separating-fact-from-perception-/Default.aspx17-May-2012 Background Extracorporeal circulation (ECC) and hypothermia are routinely used in cardiac surgery to maintain stable circulatory parameters and to increase the ischaemic tolerance of the patient. However, ECC and hypothermia cause platelet activation and dysfunction possibly followed by a...http://www.medconnect.com.my/tabid/100/ct9/c459074/Short-acting-P2Y12-blockade-to-reduce-platelet-dysfunction-and-coagulopathy/Default.aspx17-May-2012 Background Cardiac output (CO) monitoring can be useful in high-risk patients during one-lung ventilation (OLV), but it is unclear whether thermodilution-derived CO monitoring is valid during OLV. Therefore, we compared pulmonary artery (COPATD) and transcardiopulmonary thermodilution (COTPTD)...http://www.medconnect.com.my/tabid/100/ct9/c459075/Effects-of-one-lung-ventilation-on-thermodilution-derived-assessment-of-cardiac/Default.aspx17-May-2012 Background The purpose of this observational study was to investigate the relationship between splanchnic and renal blood flow during infrarenal aortic cross-clamp (XC) and postoperative gastrointestinal perfusion and function. Methods Descending aortic blood flow (DABF) was continuously...http://www.medconnect.com.my/tabid/100/ct9/c459076/Descending-aortic-blood-flow-during-aortic-cross-clamp-indicates-postoperative/Default.aspx17-May-2012 Background There are few data on the associations between anaemia, allogeneic blood transfusion (ABT), patient blood management, and outcome after arthroplasty in the UK. National agencies nevertheless instruct NHS Trusts to implement blood conservation measures including preoperative anaemia...http://www.medconnect.com.my/tabid/100/ct9/c459077/Effect-of-a-patient-blood-management-programme-on-preoperative/Default.aspx17-May-2012 Background Measuring outcomes and quality in anaesthesia is challenging. In the UK, there is increased focus on these as a result of changes in Department of Health strategy and the imminent introduction of mandatory revalidation for all doctors. A definition of quality may differ according to the...http://www.medconnect.com.my/tabid/100/ct9/c459078/Shaping-quality-the-use-of-performance-polygons-for-multidimensional/Default.aspx17-May-2012 Background Guidelines to minimize the incidence of postoperative nausea and vomiting (PONV) have been implemented in many hospitals. In previous studies, we have demonstrated that guideline adherence is suboptimal and can be improved using decision support (DS). In this study, we investigate...http://www.medconnect.com.my/tabid/100/ct9/c459079/Automated-reminders-decrease-postoperative-nausea-and-vomiting-incidence-in-a/Default.aspx17-May-2012 Background Goal-directed therapy has a secure place in perioperative care. Algorithms are based on Starling's law of the heart, notwithstanding that this does not numerically define volume or heart performance variables. These have been developed based on a Guytonian view of the circulation and...http://www.medconnect.com.my/tabid/100/ct9/c459080/High-concordance-between-expert-anaesthetists-actions-and-advice-of-decision/Default.aspx17-May-2012 Background Microvascular dysfunction is considered to play an important pathophysiological role in sepsis. We addressed the hypothesis that macrovascular and microvascular flow are uncoupled in early sepsis, using a rodent model with well-characterized haemodynamic and biochemical markers of...http://www.medconnect.com.my/tabid/100/ct9/c459081/Microvascular-and-macrovascular-flow-are-uncoupled-in-early-polymicrobial-sepsis/Default.aspx17-May-2012 Background The aim of the study was to determine whether the fibrinogen level at diagnosis of postpartum haemorrhage (PPH) is associated with the severity of bleeding. Methods This is a secondary analysis of a population-based study in 106 French maternity units identifying cases of PPH...http://www.medconnect.com.my/tabid/100/ct9/c459082/Association-between-fibrinogen-level-and-severity-of-postpartum-haemorrhage-/Default.aspx17-May-2012 Background Continuous wound infiltration (CWI), i.v. patient-controlled analgesia (i.v.-PCA), and epidural analgesia (EDA) are analgesic techniques commonly used for pain relief after open abdominal surgery. The aim of this study was to evaluate the cost-effectiveness of these...http://www.medconnect.com.my/tabid/100/ct9/c459083/Cost-effectiveness-analysis-comparing-epidural-patient-controlled-intravenous/Default.aspx17-May-2012Background and Aims: Short bowel syndrome (SBS) describes the malabsorptive state seen following extensive bowel resection. Management aims to optimise nutritional intake, promote intestinal adaptation, and prevent the development of complications. Surgical options such as autologous...http://www.medconnect.com.my/tabid/100/ct9/c459214/Caregiver-Evaluation-and-Satisfaction-With-Autologous-Bowel-Reconstruction-in/Default.aspx17-May-2012The idea that what we eat affects our health is almost too obvious to state. And yet, apart from advising patients to eat more healthily, many doctors will feel they have little to contribute to... http://www.medconnect.com.my/tabid/100/ct9/c458644/Food-matters/Default.aspx16-May-2012The UK government’s decision to use a ministerial veto to suppress an official document outlining the risks of controversial NHS reforms, despite orders to disclose it under the Freedom of... http://www.medconnect.com.my/tabid/100/ct9/c458645/Information-commissioner-condemns-health-secretary-for-failing-to-publish/Default.aspx16-May-2012US citizens are living longer but less healthy lives according to the latest annual compendium of data, a huge 583 pages, released today by the Centers for Disease Control and Prevention.Life... http://www.medconnect.com.my/tabid/100/ct9/c458646/US-citizens-are-less-healthy-but-living-longer-report-says/Default.aspx16-May-2012Along with poverty, less schooling linked to more chronic disease, disability and shorter life (Source: Primary Care News - Doctors Lounge)http://www.medconnect.com.my/tabid/100/ct9/c459139/Education-Is-Key-to-Health-Report/Default.aspx16-May-2012Recent epidemiological and experimental studies suggest a link between cognitive decline in late adulthood and sports concussions sustained in early adulthood. In order to provide the first in vivo neuroanatomical evidence of this relation, the present stu... (Source: SafetyLit: All...http://www.medconnect.com.my/tabid/100/ct9/c459140/Sports-Concussions-and-Aging-A-Neuroimaging-Investigation-Tremblay-S-/Default.aspx16-May-2012Exercise in cold environments exerts a unique physiologic stress on the human body, which, under certain conditions, may result in a cold-related injury. Environmental factors are the most important risk factors for the development of hypothermia in athlet... (Source: SafetyLit: All (Unduplicated))http://www.medconnect.com.my/tabid/100/ct9/c459141/Cold-weather-issues-in-sideline-and-event-management-McMahon-JA-Howe-A-/Default.aspx16-May-2012ABSTRACT: There are a few national position stands/guidelines that address environmental conditions in athletics, yet they do not govern all outdoor sports. Extreme heat and cold, lightning, and severe wind can all be fatal, yet the majority of outdoor spo... (Source: SafetyLit: All (Unduplicated))http://www.medconnect.com.my/tabid/100/ct9/c459142/Lightning-and-severe-thunderstorms-in-event-management-Walsh-KM-/Default.aspx16-May-2012When athletes, warfighters, and laborers perform intense exercise in the heat, the risk of exertional heat stroke (EHS) is ever present. The recent data regarding the fatalities due to EHS within the confines of organized American sport are not promising: ... (Source: SafetyLit: All (Unduplicated))http://www.medconnect.com.my/tabid/100/ct9/c459143/Exertional-heat-stroke-new-concepts-regarding-cause-and-care-/Default.aspx16-May-2012ABSTRACT: Running has evolved throughout history from a necessary form of locomotion to an athletic and recreational pursuit. During this transition, our barefoot ancestors developed footwear. By the late 1970s, running popularity surged, and footwear manu... (Source: SafetyLit: All (Unduplicated))http://www.medconnect.com.my/tabid/100/ct9/c459144/The-barefoot-debate-can-minimalist-shoes-reduce-running-related-injuries-/Default.aspx16-May-2012Have you ever wondered how much medical “success” is simply down to patients failing to tell us what we’ve got wrong? Insight into patient experience comes from surprising sources at times. I... http://www.medconnect.com.my/tabid/100/ct9/c458647/A-lesson-from-a-bike-shop/Default.aspx16-May-2012Researchers investigated recent trends in the use of bariatric surgery in England. In particular, they examined the surgical techniques used and factors influencing postoperative outcomes. A... http://www.medconnect.com.my/tabid/100/ct9/c458653/Non-parametric-statistical-tests-for-independent-groups-numerical-data/Default.aspx16-May-2012David Southall, a professor of paediatrics and child protection specialist with a world reputation, was hauled before the UK medical regulator not once but three times, accused of serious... http://www.medconnect.com.my/tabid/100/ct9/c458655/David-Southall-anatomy-of-a-wrecked-career/Default.aspx16-May-2012Richard William Beard was professor of obstetrics and gynaecology at St Mary’s Hospital, Paddington, from 1972 to 1996. He was known for his kind, often self effacing personality, and his main... http://www.medconnect.com.my/tabid/100/ct9/c458656/Richard-William-Beard/Default.aspx16-May-2012Eric Philip Simkin originally wanted to be an orthopaedic surgeon, but during a registrar post at the old Liverpool Royal Infirmary he realised his true vocation was anorectal surgery. In 1967 he was... http://www.medconnect.com.my/tabid/100/ct9/c458657/Eric-Philip-Simkin/Default.aspx16-May-2012Born in Edinburgh, Brian John Chapman attended Daniel Stewart’s School, where he was Dux. He then entered medical school at the University of Edinburgh, where he met his wife Dorothy. The couple... http://www.medconnect.com.my/tabid/100/ct9/c458659/Brian-John-Chapman/Default.aspx16-May-2012Andrew James Stanford’s early career was very varied and completely different from the regulated pathways that have to be followed now. Born in Sutton on Hull, he studied medicine at Kings College,... http://www.medconnect.com.my/tabid/100/ct9/c458662/Andrew-James-Stanford/Default.aspx16-May-2012The British government has recently established the Troubled Families Programme in response to the riots in England in 2011, scaling up a non-negotiable version of the previous government’s Family... http://www.medconnect.com.my/tabid/100/ct9/c458664/The-British-governments-Troubled-Families-Programme/Default.aspx16-May-2012An international team of scientists has launched a drive to highlight the dangers of excessive drinking, which is thought to cause one in every eight deaths in people aged 15 to 64 years in... http://www.medconnect.com.my/tabid/100/ct9/c458666/Experts-launch-Europe-wide-drive-to-highlight-dangers-of-alcohol/Default.aspx16-May-2012The English Department of Health has consulted on its proposals to change the management of healthcare workers who are infected with HIV. It recommends relaxing the restriction on such workers... http://www.medconnect.com.my/tabid/100/ct9/c458667/Discrimination-against-doctors-with-HIV-must-end/Default.aspx16-May-2012Don't neglect exercise (Source: The Doctors Lounge - Health News)MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctorshttp://www.medconnect.com.my/tabid/100/ct9/c459145/Health-Tip-When-Physical-Therapy-Ends/Default.aspx16-May-2012Women who undergo abdominal liposuction and don?t follow an exercise regimen may add visceral fat after the procedure, according to a small study. (Source: Modern Medicine)http://www.medconnect.com.my/tabid/100/ct9/c459146/Visceral-fat-may-increase-after-liposuction/Default.aspx16-May-2012SummaryHigh‐risk surgery is performed in every acute hospital. These patients often have increased peri‐operative risk related to their poor cardiorespiratory reserve. Formal risk assessment is recommended for such patients; cardiopulmonary exercise testing is a well established triage tool, but is...http://www.medconnect.com.my/tabid/100/ct9/c459147/Use-of-the-pre-operative-shuttle-walk-test-to-predict/Default.aspx16-May-2012Even moderate activity like taking a walk may improve cancer survivors' long-term prognosis, according to new research showing that regular exercise can lower survivors' risk of premature death, not only from cancer but from any cause. (Source: NYT)http://www.medconnect.com.my/tabid/100/ct9/c459148/Well-Phys-Ed-Cancer-Survivors-Who-Exercise-Live-Longer/Default.aspx16-May-2012Conclusion:  The authors believe that learning anatomy via a surgical approach provides a relevant, in‐depth, purposeful and enjoyable learning experience. This technique also provided a valuable insight into surgery. (Source: The Clinical Teacher)http://www.medconnect.com.my/tabid/100/ct9/c459149/Cadaveric-surgery-a-novel-approach-to-teaching-clinical-anatomy/Default.aspx16-May-2012Discussion:  Having completed the same set of assessments, senior medical students are well placed to prepare more junior colleagues for their examinations. This exercise offered valuable teaching experience for the tutors, and also highlighted numerous areas of development for future iterations....http://www.medconnect.com.my/tabid/100/ct9/c459150/Utility-of-a-student-organised-revision-day/Default.aspx16-May-2012Some football, hockey players show postseason decline, study finds (Source: The Doctors Lounge - Neurology)http://www.medconnect.com.my/tabid/100/ct9/c459151/Head-Blows-May-Hamper-Learning-in-College-Athletes/Default.aspx16-May-2012Nature 485, 7398 (2012). doi:10.1038/485307a Whether sprinting, swimming, lifting or leaping, elite athletes in action are phenomenal — and, as biochemist and sports scientist Chris Cooper shows in this pacy account, some are also assisted by performance-enhancing drugs. To understand a...http://www.medconnect.com.my/tabid/100/ct9/c459152/Books-in-brief/Default.aspx16-May-2012Nature. doi:10.1038/485S18a Author: Scott P. Edwards While type 1 diabetes might be promising ground for a vaccine, the most effective way to avoid type 2 remains good old-fashioned diet and exercise. (Source: Nature)MedWorm Sponsor Message: Please support the Doctors In Chains campaign for...http://www.medconnect.com.my/tabid/100/ct9/c459153/Prevention-Nipped-in-the-bud/Default.aspx16-May-2012Int J Sports MedDOI: 10.1055/s-0031-1298001The purposes of this study were to prospectively determine changes in rotator cuff strength before and after surgical shoulder stabilization by Bristow-Latarjet procedure and to better estimate time needed for rotator cuff strength recovery. 20 patients...http://www.medconnect.com.my/tabid/100/ct9/c459154/Recovery-of-Rotators-Strength-after-Latarjet-Surgery/Default.aspx16-May-2012This study aimed to determine whether maximal lactate steady state (MLSS) represents a boundary above which not only physiological but also technical changes occur. On different days, 13 male swimmers (23±9 years) performed the following tests: 1) a 400-m all-out swim, to determine maximal aerobic...http://www.medconnect.com.my/tabid/100/ct9/c459155/Stroking-Parameters-during-Continuous-and-Intermittent-Exercise-in-Regional-Level/Default.aspx16-May-2012In this study we investigated whether RSI is associated with endothelial dysfunction and impaired exercise-induced blood flow in the affected forearm. 10 patients with RSI (age, 40.2±10.3; BMI, 23.8±3.3) and 10 gender- and age-matched control subjects (age, 38.0±12.4; BMI, 22.7±3.4) participated in...http://www.medconnect.com.my/tabid/100/ct9/c459156/Impaired-Endothelial-Function-and-Blood-Flow-in-Repetitive-Strain-Injury/Default.aspx16-May-2012Int J Sports MedDOI: 10.1055/s-0032-1311591The purpose of the current study was to investigate the effects of different wheel sizes, with fixed gear ratios, on maximal effort mobility performance in wheelchair athletes. 13 highly trained wheelchair basketball players, grouped by classification...http://www.medconnect.com.my/tabid/100/ct9/c459157/The-Effect-of-Wheel-Size-on-Mobility-Performance-in-Wheelchair-Athletes/Default.aspx16-May-2012We present the case of a 40 year old male semi-professional bodybuilder with systemic infection and painful reddened swellings of the right upper arm forcing him to discontinue weightlifting. Over the last 8 years he daily self-injected sterilized sesame seed oil at numerous intramuscular locations...http://www.medconnect.com.my/tabid/100/ct9/c459158/Irreversible-Muscle-Damage-in-Bodybuilding-due-to-Long-Term-Intramuscular/Default.aspx16-May-2012Int J Sports MedDOI: 10.1055/s-0032-1311585The aim of this study was to investigate the effects of overtraining on skeletal muscle growth and growth-related gene expression. The rats of overtraining group (OT) and overtraining recovery group (OTR) were subject to 11 experimental weeks of...http://www.medconnect.com.my/tabid/100/ct9/c459159/Effects-of-Overtraining-on-Skeletal-Muscle-Growth-and-Gene-Expression/Default.aspx16-May-2012We examined the effects of listening to music on attentional focus, rating of perceived exertion (RPE), pacing strategy and performance during a simulated 5-km running race. 15 participants performed 2 controlled trials to establish their best baseline time, followed by 2 counterbalanced...http://www.medconnect.com.my/tabid/100/ct9/c459160/Listening-to-Music-in-the-First-but-not-the/Default.aspx16-May-2012Int J Sports MedDOI: 10.1055/s-0031-1299753The purpose of this study was to describe the VO2 kinetics above and below respiratory compensation point (RCP) during swimming. After determination of the gas-exchange threshold (GET), RCP and VO2max, 9 well-trained swimmers (21.0±7.1 year,...http://www.medconnect.com.my/tabid/100/ct9/c459161/VO2-Kinetics-During-Heavy-and-Severe-Exercise-in-Swimming/Default.aspx16-May-2012In conclusion, capillary sampling is a valid technique for measuring bound cortisol across a range of concentrations.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: International Journal of Sports Medicine)http://www.medconnect.com.my/tabid/100/ct9/c459162/Capillary-Cortisol-Sampling-during-High-Intensity-Exercise/Default.aspx16-May-2012Since Achilles tendon healing is protracted, more knowledge of metabolites known to meet the demands for biosynthesis and proliferation is needed. We hypothesized that essential metabolites, glutamate, glucose, lactate, pyruvate and glycerol, are present and upregulated in healing Achilles tendons....http://www.medconnect.com.my/tabid/100/ct9/c459713/Metabolic-activity-in-early-tendon-repair-can-be-enhanced/Default.aspx16-May-2012CONCLUSIONS: The physical therapy treatment was effective in treating and/or curing the symptoms of UI, whether or not associated with pelvic prolapse, regardless of the clinical type of incontinence. Clinical Trial Registration (Brazilian Clinical Trial Registry): RBR-3p5s66. (Source: Revista...http://www.medconnect.com.my/tabid/100/ct9/c459163/Physical-therapy-intervention-in-women-with-urinary-incontinence-associated/Default.aspx16-May-2012BACKGROUND: Exercise training (ET) can reduce blood pressure (BP) and prevent functional disability. However, the effects of low volumes of training have been poorly studied, especially in elderly hypertensive patients. OBJECTIVES: To investigate the effects of a multi-component ET program (aerobic...http://www.medconnect.com.my/tabid/100/ct9/c459164/Exercise-training-program-based-on-minimum-weekly-frequencies-effects/Default.aspx16-May-2012Diet related disease leads to about 70 000 premature deaths in the United Kingdom.1 The rising prevalence of obesity is a signal that the food system is out of kilter with public health priorities.... http://www.medconnect.com.my/tabid/100/ct9/c457708/A-system-wide-challenge-for-UK-food-policy/Default.aspx16-May-2012Over the past few years, sports-related concussion has received significant media attention making it one of the most, if not highest profile neurological disorder. Thirty-one states now have passed sports concussion laws, with 14 states pending legislatio... (Source: SafetyLit: All (Unduplicated))http://www.medconnect.com.my/tabid/100/ct9/c459165/Sports-related-concussion-the-role-of-the-headache-specialist-Conidi-FX-/Default.aspx16-May-2012In a better world, vaccine mandates wouldn’t be necessary. Parents would educate themselves about the diseases that vaccines prevent and learn that measles causes pneumonia and brain damage, mumps... http://www.medconnect.com.my/tabid/100/ct9/c457726/Should-childhood-vaccination-be-mandatory-Yes/Default.aspx16-May-2012Mandatory vaccination in the UK was attempted first in the 19th century.1 The legislation was ineffective, discriminated in favour of those able to use the exemptions, and was divisive; it fostered... http://www.medconnect.com.my/tabid/100/ct9/c457728/Should-childhood-vaccination-be-mandatory-No/Default.aspx16-May-2012In September 2011, the United Nations held a high level meeting of the general assembly on the prevention and control of non-communicable diseases.1 The meeting was held in response to the increasing... http://www.medconnect.com.my/tabid/100/ct9/c457730/Food-policies-for-healthy-populations-and-healthy-economies/Default.aspx16-May-2012In the past year Denmark has introduced a “fat tax,” Hungary a “junk food tax,” and France a tax on sweetened drinks.1 2 Peru has announced plans to tax junk food, and other countries, notably... http://www.medconnect.com.my/tabid/100/ct9/c457732/Taxing-unhealthy-food-and-drinks-to-improve-health/Default.aspx16-May-2012 We read with great interest the paper by Hajnajeeb et al1 about the role of optical coherence tomography in identifying the shape and size of idiopathic epiretinal membranes (ERM). We have some concerns and comments about the study. Although the authors stated the investigators were blinded to...http://www.medconnect.com.my/tabid/100/ct9/c458046/Comment-on-The-role-of-the-optical-coherence-tomography/Default.aspx16-May-2012 Mycotic keratitis is a leading cause of ocular morbidity throughout the world and a higher incidence of fungal keratitis has been reported from tropical and subtropical countries. Early diagnosis is important for the prompt management of this disorder. Among the various diagnostic tests available,...http://www.medconnect.com.my/tabid/100/ct9/c458049/Evaluation-of-three-PCR-assays-for-the-detection-of/Default.aspx16-May-2012 Dr William Briggs (figure 1) was a 17th century physician with the distinction of being one of the first to specialise in ophthalmology. Despite competition with established quacks and charlatans such as the illiterates Sir William Read and Roger Grant, he established a reputation as an honest...http://www.medconnect.com.my/tabid/100/ct9/c457959/The-great-and-the-wrong-Dr-William-Briggs/Default.aspx16-May-2012 Background/aims To assess the current number of ophthalmologists practicing worldwide in 2010 and to create a system for maintaining, collecting and improving the accuracy of data on ophthalmologists per population, ophthalmologists performing surgery, growth rate of the profession, and the number...http://www.medconnect.com.my/tabid/100/ct9/c457961/The-number-of-ophthalmologists-in-practice-and-training-worldwide-/Default.aspx16-May-2012 Background The aim of this study was to perform the first femtosecond laser cuts with a new prototype femtosecond laser, in vivo and to evaluate its safety, stability and efficacy. Methods A LASIK cut was performed with a prototype 200 kHz femtosecond laser in both eyes of nine patients and one...http://www.medconnect.com.my/tabid/100/ct9/c457966/First-clinical-results-with-a-new-200-kHz-femtosecond-laser-system/Default.aspx16-May-2012 Aim To report the clinical and microbiological profile of patients with microsporidial keratoconjunctivitis in a tertiary eye care centre in India. Methods A retrospective analysis of medical records of all cases of microbiologically confirmed microsporidial keratoconjunctivitis, who presented...http://www.medconnect.com.my/tabid/100/ct9/c457969/Diagnosis-clinical-features-and-treatment-outcome-of-microsporidial/Default.aspx16-May-2012 Purpose To describe the epidemiology, clinical features, management and outcomes of paediatric Mooren's peripheral ulcerative keratitis. Methods All patients with Mooren's ulcer aged <18 years presenting at a single centre from 1987 to 2010 were enrolled. Epidemiological features,...http://www.medconnect.com.my/tabid/100/ct9/c457973/Moorens-ulcer-in-children/Default.aspx16-May-2012 Background Conjunctival ultraviolet autofluorescence (UVAF) photography was developed to detect and characterise pre-clinical sunlight-induced UV damage. The reliability of this measurement and its relationship to outdoor activity are currently unknown. Methods 599 people aged...http://www.medconnect.com.my/tabid/100/ct9/c457976/Reliability-and-validity-of-conjunctival-ultraviolet-autofluorescence-measurement/Default.aspx16-May-2012 Aims To compare the biomechanical properties of the cornea and intraocular pressure (IOP) between patients with nanophthalmos and age-matched controls. Methods In this prospective, cross-sectional and comparative study, 27 eyes of 27 healthy individuals (control group) and 27 eyes of 27 patients...http://www.medconnect.com.my/tabid/100/ct9/c457979/Corneal-biomechanical-properties-and-intraocular-pressure-measurement-in-patients/Default.aspx16-May-2012 Background To examine factors associated with progression of open-angle glaucoma in a population-based setting. Methods The population-based Beijing Eye Study, which included 4439 subjects with an age of 40+ years in the year 2001, was repeated in 2006. Optic disc photographs of the baseline...http://www.medconnect.com.my/tabid/100/ct9/c457983/Frequency-and-associated-factors-of-structural-progression-of-open-angle/Default.aspx16-May-2012 Aims To review the characteristics of patients attending a tertiary ophthalmic referral centre certified as sight impaired (SI) or severely sight impaired (SSI) from glaucoma. Methods One hundred consecutive patients certified SI/SSI from the Glaucoma Service at Moorfields Eye Hospital, London,...http://www.medconnect.com.my/tabid/100/ct9/c457986/Avoidable-sight-loss-from-glaucoma-is-it-unavoidable-/Default.aspx16-May-2012 Aim To assess the risk factors for anxiety and depression in patients with glaucoma. Methods Anxiety and depression in 408 patients with glaucoma were evaluated using the hospital anxiety and depression scale (HADS) questionnaire, which consists of two subscales, representing HADS-anxiety...http://www.medconnect.com.my/tabid/100/ct9/c457989/Risk-factors-for-anxiety-and-depression-in-patients-with-glaucoma/Default.aspx16-May-2012 Aim To evaluate the ocular surface symptoms and signs associated with preservative-free 0.0015% tafluprost in patients with glaucoma or ocular hypertension (OHT). Methods Prospective non-interventional, multicentre, observational study on 134 patients, naive or on previous treatment with another...http://www.medconnect.com.my/tabid/100/ct9/c457992/Spanish-multicenter-tafluprost-tolerability-study/Default.aspx16-May-2012 Backgrounds/aims To evaluate the agreement of parapapillary retinal nerve fibre layer (RNFL) thickness among three spectral-domain optical coherence tomography (OCT) instruments. Methods Two hundred and three glaucomatous eyes and 88 normal eyes were imaged by Cirrus, RTVue and 3D OCT. The...http://www.medconnect.com.my/tabid/100/ct9/c457995/Agreement-among-three-types-of-spectral-domain-optical-coherent-tomography/Default.aspx16-May-2012 Background There is considerable evidence to show that strabismus patients report their quality of life (QoL) as lower than normal controls. While the majority of patients with strabismus are treated with surgery there are a number of cases where surgery is not possible and good long-term ocular...http://www.medconnect.com.my/tabid/100/ct9/c457998/The-effect-on-quality-of-life-of-long-term-botulinum/Default.aspx16-May-2012 Aim To evaluate outcomes of patients with oculopharyngeal muscular dystrophy (OPMD) with levator function (LF) ≥10mm who underwent primary bilateral silicone frontalis suspension. Methods 31 patients with OPMD satisfied the following inclusion criteria: LF ≥10 mm; no previous eyelid...http://www.medconnect.com.my/tabid/100/ct9/c458001/Primary-bilateral-silicone-frontalis-suspension-for-good-levator-function/Default.aspx16-May-2012 Aim To examine the impact of bilateral or unilateral cataract surgery on visual functioning. Methods The Singapore Malay Eye Study is a population-based study of 3280 Singapore Malay patients aged 40–80 years, of which 3225 had data available for inclusion. Cataracts were graded from...http://www.medconnect.com.my/tabid/100/ct9/c458004/The-impact-of-bilateral-or-unilateral-cataract-surgery-on/Default.aspx16-May-2012 Aim The long-term course of juvenile idiopathic arthritis (JIA)-associated uveitis is not known yet. This study investigates the course and activity of JIA-associated uveitis in childhood and puberty. Design Retrospective study of the clinical data of 62 JIA patients with uveitis. The main...http://www.medconnect.com.my/tabid/100/ct9/c458007/The-clinical-course-of-juvenile-idiopathic-arthritis-associated-uveitis-in/Default.aspx16-May-2012 Background Case reports suggest a potential association between coeliac disease (CD) and uveitis, but larger well-controlled studies are lacking. The aim of this study was therefore to examine the risk of uveitis in patients with biopsy-verified CD. Methods Small intestinal biopsy reports...http://www.medconnect.com.my/tabid/100/ct9/c458010/Increased-risk-of-uveitis-in-coeliac-disease-a-nationwide-cohort-study/Default.aspx16-May-2012 Aims To describe and compare the causative organisms, clinical features and visual outcomes of endophthalmitis following intravitreal injection (IVI) to endophthalmitis following cataract surgery. Methods Patient population and setting: A retrospective case series of patients with acute...http://www.medconnect.com.my/tabid/100/ct9/c458013/Endophthalmitis-following-intravitreal-injection-versus-endophthalmitis-following/Default.aspx16-May-2012 AIM Currently, the border of idiopathic epiretinal membranes (iERM) is outlined intraoperatively using vital dyes. Therefore, the authors set out to investigate the role of the preoperative retinal thickness map (RTM) of the optical coherence tomography (OCT) in identifying the shape and the size...http://www.medconnect.com.my/tabid/100/ct9/c458016/The-role-of-the-optical-coherence-tomography-in-identifying/Default.aspx16-May-2012 Aims Associations among hypertension, diabetes mellitus and some ophthalmic diseases are well established; associations with others are more equivocal. The aim was to quantify associations accurately using large epidemiological datasets. Methods Analysis of the Oxford Record Linkage Study (ORLS),...http://www.medconnect.com.my/tabid/100/ct9/c458019/Risk-of-selected-eye-diseases-in-people-admitted-to/Default.aspx16-May-2012 Background/aims We have previously introduced electroretinography (ERG) as a proxy for visual function to monitor for retinal toxicity due to intra-arterial chemotherapy for retinoblastoma in young children. In this paper, we report ERG results for patients with retinoblastoma receiving initial...http://www.medconnect.com.my/tabid/100/ct9/c458022/ERG-monitoring-of-retinal-function-during-systemic-chemotherapy-for-retinoblastoma/Default.aspx16-May-2012 Aim To report the experience of the authors with efficacy and toxicity of periocular chemotherapy over a 12-year period. Methods 102 periocular injections of 2 cc (10 mg of carboplatin/1 cc) were given every 4–6 weeks in 33 eyes of 29 patients. Patient's data were...http://www.medconnect.com.my/tabid/100/ct9/c458025/Periocular-carboplatin-for-retinoblastoma-long-term-report-12-years-on/Default.aspx16-May-2012 Aim To describe the incidence of retinocytomas, their variability at presentation and their growth patterns both before and after regression. Methods Medical notes of the 525 patients of the Jules-Gonin Eye Hospital Retinoblastoma Clinic between 1964 and 2008 were reviewed and the charts of 36...http://www.medconnect.com.my/tabid/100/ct9/c458028/Phenotypic-variability-of-retinocytomas-preregression-and-postregression-growth/Default.aspx16-May-2012 Background Knobloch syndrome is defined as a triad of occipital defect, high myopia and vitreo-retinal degeneration (often with later retinal detachment); however, the ocular phenotype is not well defined. This report characterises eye findings of the syndrome in children with genetically...http://www.medconnect.com.my/tabid/100/ct9/c458031/The-distinct-ophthalmic-phenotype-of-Knobloch-syndrome-in-children/Default.aspx16-May-2012 Purpose To analyse the types of systematic reviews and meta-analyses published in the field of ophthalmology. Methods The systematic reviews and meta-analysis in ophthalmology published in peer-reviewed journals were retrieved. The distribution of systematic reviews and meta-analyses in various...http://www.medconnect.com.my/tabid/100/ct9/c458033/Survey-of-systematic-reviews-and-meta-analyses-published-in-ophthalmology/Default.aspx16-May-2012 Aims To investigate age-related lesions in the far-anterior retina that migrate from the ciliary body (CB) and how they affect the neural retina and retinal pigmented epithelium (RPE). Methods One eye from three healthy subjects aged 87, 92 and 93 years were used. Retinae were photographed,...http://www.medconnect.com.my/tabid/100/ct9/c458037/Aged-peripheral-retinal-lesions-originating-from-the-ciliary-body/Default.aspx16-May-2012 Aims To determine the effect of intracamerally injected voriconazole on corneal endothelial cells in rabbit eyes. Methods Various concentrations of voriconazole (0%, 0.03%, 0.1%, 0.25%, 0.5% and 1%) were injected intracamerally in 36 eyes of 18 rabbits (six eyes for each concentration)....http://www.medconnect.com.my/tabid/100/ct9/c458040/Toxicity-of-voriconazole-on-corneal-endothelial-cells-in-an-animal-model/Default.aspx16-May-2012 A 34-year-old Caucasian man presented to the ophthalmology emergency clinic with painless, bilateral upper and lower eyelid oedema since waking up that morning. The patient denied any history of lip swelling, tongue swelling, or shortness of breath. He reported a recent episode of an upper...http://www.medconnect.com.my/tabid/100/ct9/c458042/Acute-episode-of-eyelid-oedema/Default.aspx16-May-2012 What is Global Health? Globalisation has created a myriad of unprecedented challenges and opportunities for healthcare systems. For decades, the health systems of wealthier nations have benefited from the migration of healthcare workers from resource-poor areas of the world. This ‘brain...http://www.medconnect.com.my/tabid/100/ct9/c457953/Global-health-for-future-ophthalmologists-time-to-address-the-gaps-a-UK-perspective/Default.aspx16-May-2012 Microbial keratitis is an old disease and is not limited to humans, but we have a unique ability to change its prevalence and epidemiology, unlike other animals. Ten to eight thousand years ago, we were a hunter-gatherer species with an average life span of 20–30 years.1 Trauma was...http://www.medconnect.com.my/tabid/100/ct9/c457955/The-changing-spectrum-of-microbial-keratitis-is-microsporia-increasing-as/Default.aspx16-May-2012 Endophthalmitis remains one of the most damaging and challenging complications following Boston keratoprosthesis type 1 (KPro) surgery. The authors reviewed the literature from 2001 onward to identify cases of endophthalmitis following KPro surgery and present an additional case of endophthalmitis...http://www.medconnect.com.my/tabid/100/ct9/c457956/Review-of-endophthalmitis-following-Boston-keratoprosthesis-type-1/Default.aspx16-May-2012 Nutritional supplementation is now a multibillion-dollar industry, and about half of all US adults take supplements. Supplement use is fueled in part by the belief that nutritional supplements can ward off chronic disease, including cancer, although several expert committees and organizations have...http://www.medconnect.com.my/tabid/100/ct9/c457601/Dietary-Supplements-and-Cancer-Prevention-Balancing-Potential-Benefits-Against/Default.aspx16-May-2012 Background Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking-related health outcomes. Previous studies have...http://www.medconnect.com.my/tabid/100/ct9/c457603/Association-Between-Genetic-Variants-on-Chromosome-15q25-Locus-and-Objective/Default.aspx16-May-2012 Background Glycogen synthase kinase-3β (GSK-3β), a serine/threonine protein kinase, may function as a tumor suppressor or an oncogene, depending on the tumor type. We sought to determine the biological function of GSK-3β in osteosarcoma, a rare pediatric cancer for which the...http://www.medconnect.com.my/tabid/100/ct9/c457605/Glycogen-Synthase-Kinase-3{beta}-NF-{kappa}B-Signaling-and-Tumorigenesis-of-Human/Default.aspx16-May-2012 Background Both the European Neuroendocrine Tumor Society (ENETS) and the International Union for Cancer Control/American Joint Cancer Committee/World Health Organization (UICC/AJCC/WHO) have proposed TNM staging systems for pancreatic neuroendocrine neoplasms. This study aims to identify the most...http://www.medconnect.com.my/tabid/100/ct9/c457608/TNM-Staging-of-Neoplasms-of-the-Endocrine-Pancreas-Results/Default.aspx16-May-2012 Hepatitis D virus (HDV) is dependent on the presence of hepatitis B virus (HBV) for transmission and replication because of its inability to produce its own coat. It remains unclear whether HDV infection increases the risk of hepatocellular carcinoma. Using the Swedish Hospital Discharge Register...http://www.medconnect.com.my/tabid/100/ct9/c457610/A-Population-Based-Study-of-Hepatitis-D-Virus-as-Potential/Default.aspx16-May-2012Swimming is second only to walking as the nation's most popular recreational activity, and its benefits can be enjoyed regardless of age or infirmity. (Source: NYT)http://www.medconnect.com.my/tabid/100/ct9/c458137/Personal-Health-Personal-Health-The-Zen-of-Swimming/Default.aspx16-May-2012Staying in shape lowered odds of developing hypertension by up to 42 percent in study (Source: The Doctors Lounge - Health News)http://www.medconnect.com.my/tabid/100/ct9/c458138/Fitness-Fights-High-Blood-Pressure-Even-With-Family-History/Default.aspx16-May-2012 This article is currently available as a free download on ingentaconnect http://www.medconnect.com.my/tabid/100/ct9/c458093/Tuberculosis-care-why-the-words-we-use-matter-Editorial-/Default.aspx16-May-2012 This article is currently available as a free download on ingentaconnect http://www.medconnect.com.my/tabid/100/ct9/c458094/Declaration-on-palliative-care-and-MDR-XDR-TB-Editorial-/Default.aspx16-May-2012 This article is currently available as a free download on ingentaconnect http://www.medconnect.com.my/tabid/100/ct9/c458095/Language-in-tuberculosis-services-can-we-change-to-patient-centred/Default.aspx16-May-2012 This article is currently available as a free download on ingentaconnect http://www.medconnect.com.my/tabid/100/ct9/c458099/The-chemotherapy-of-tuberculosis-past-present-and-future-State-of-the-art-/Default.aspx16-May-2012 This article is currently available as a free download on ingentaconnect http://www.medconnect.com.my/tabid/100/ct9/c458101/2011-The-year-in-review-Part-I-Tuberculosis/Default.aspx16-May-2012Attention, college students cramming between midterms and finals: Binging on soda and sweets for as little as six weeks may make you stupid.    A new UCLA study is the first to show how a diet steadily high in fructose slows the brain, hampering memory and learning — and how...http://www.medconnect.com.my/tabid/100/ct9/c459166/This-is-your-brain-on-sugar-UCLA-study-shows/Default.aspx16-May-2012bmj;344/may15_3/e3362/FIG1F1fig1Age is what really determines health need, the health secretary for England believes. When the new clinical commissioning groups are up and running, areas with lots of... http://www.medconnect.com.my/tabid/100/ct9/c457709/Allocation-of-NHS-resources-are-some-patients-more-equal-than-others-/Default.aspx15-May-2012The Radio 4 Today programme heralded a day of wall to wall epigenetics. “Every now and then a new word emerges from scientific journals that lay people have to get used to. Such a word is... http://www.medconnect.com.my/tabid/100/ct9/c457710/Can-a-simple-blood-test-really-predict-breast-cancer-/Default.aspx15-May-2012For the third time in a row the Netherlands has come top in an exercise to gauge which country’s residents are most satisfied with their healthcare system, have the best outcomes, and have the best... http://www.medconnect.com.my/tabid/100/ct9/c457711/Netherlands-tops-European-healthcare-league-with-UK-coming-in-at-12th/Default.aspx15-May-2012The European Union is taking the highly unusual step of amending new measures on drug safety before the legislation introducing them, agreed almost 18 months ago, has even come into force.The move to... http://www.medconnect.com.my/tabid/100/ct9/c457718/EU-tightens-drug-safety-law-before-it-is-even-implemented/Default.aspx15-May-2012A government review has concluded that the UK regulator of medical devices, the Medicines and Healthcare Products Regulatory Agency (MHRA), acted “reasonably” in communicating to the public safety... http://www.medconnect.com.my/tabid/100/ct9/c457720/Device-regulator-is-told-to-improve-its-safety-monitoring/Default.aspx15-May-2012More than 100 000 doctors across the United Kingdom are being asked to vote on whether they are prepared to provide only urgent and emergency care for 24 hours in protest at the government’s changes... http://www.medconnect.com.my/tabid/100/ct9/c457722/UK-doctors-vote-on-industrial-action-for-first-time-in-37-years/Default.aspx15-May-2012Pfizer Australia has been accused of breaching regulations banning advertisements aimed directly at consumers by placing in the media what it calls “community service announcements” about its... http://www.medconnect.com.my/tabid/100/ct9/c457724/Pfizer-Australia-faces-scrutiny-over-atorvastatin-advertising-campaign/Default.aspx15-May-2012Routine exercise echocardiography in asymptomatic patients after revascularization does not lead to better outcomes, according to a new study published in Archives of Internal Medicine. Although guidelines generally discourage the practice, post-revascularization stress tests are still commonly...http://www.medconnect.com.my/tabid/100/ct9/c458139/No-Benefit-Found-For-Exercise-Echocardiography-In-Asymptomatic-Patients/Default.aspx15-May-2012 Recent evidence suggests that young men and women may have different strategies for regulating arterial blood pressure, and the purpose of the present study was to determine if sex differences exist in diastolic arterial pressure (DAP) and muscle sympathetic nerve activity (MSNA) relations during...http://www.medconnect.com.my/tabid/100/ct9/c458130/Sex-differences-in-hemodynamic-and-sympathetic-neural-firing-patterns/Default.aspx15-May-2012 The purpose of this study was to investigate the effects of mild therapeutic exercise (treadmill) in preventing the inactivity-induced alterations in contractile properties (e.g., power, force, and velocity) of type I soleus single fibers in three different age groups. Young adult (5- to...http://www.medconnect.com.my/tabid/100/ct9/c458131/Differential-effects-of-mild-therapeutic-exercise-during-a-period/Default.aspx15-May-2012 Synaptic activity can modify expression of neurotrophins, which influence the development of neuronal circuits. In the newborn rat, early hyperoxia silences the synaptic activity and input from the carotid body, impairing the development and function of chemoreceptors. The purpose of this study...http://www.medconnect.com.my/tabid/100/ct9/c458132/Effect-of-hyperoxic-exposure-during-early-development-on-neurotrophin/Default.aspx15-May-2012 Skeletal muscle is one of the most sensitive tissues to mechanical loading, and unloading inhibits the regeneration potential of skeletal muscle after injury. This study was designed to elucidate the specific effects of unloading stress on the function of immunocytes during muscle regeneration...http://www.medconnect.com.my/tabid/100/ct9/c458133/Unloading-stress-disturbs-muscle-regeneration-through-perturbed-recruitment-and/Default.aspx15-May-2012 This investigation examined the effects of acute resistance exercise (RE), progressive resistance training (PRT), and age on the human skeletal muscle Transcriptome. Two cohorts of young and old adults [study A: 24 yr, 84 yr (n = 28); study B: 25 yr, 78 yr (n = 36)] were studied. Vastus lateralis...http://www.medconnect.com.my/tabid/100/ct9/c458118/Transcriptome-signature-of-resistance-exercise-adaptations-mixed-muscle-and/Default.aspx15-May-2012 Obesity is associated with alterations in upper airway collapsibility during sleep. Obese, leptin-deficient mice demonstrate blunted ventilatory control, leading us to hypothesize that (1) obesity and leptin deficiency would predispose to worsening neuromechanical upper airway function and that...http://www.medconnect.com.my/tabid/100/ct9/c458119/Effects-of-leptin-and-obesity-on-the-upper-airway-function/Default.aspx15-May-2012 Reactive oxygen species (ROS) are essential in vascular homeostasis but may contribute to vascular dysfunction when excessively produced. Superoxide anion (O2·–) can directly affect vascular tone by reacting with K+ channels and indirectly by reacting with nitric oxide (NO), thereby...http://www.medconnect.com.my/tabid/100/ct9/c458120/Nitroso-redox-balance-in-control-of-coronary-vasomotor-tone/Default.aspx15-May-2012 Lower limb exercise increases upper limb conduit artery blood flow and shear stress, and leg exercise training can enhance upper limb vascular function. We therefore examined the contribution of shear stress to changes in vascular function in the nonexercising upper limbs in response to lower limb...http://www.medconnect.com.my/tabid/100/ct9/c458121/Brachial-artery-adaptation-to-lower-limb-exercise-training-role-of-shear-stress/Default.aspx15-May-2012 Low concentrations of inhaled hydrogen sulfide (H2S) induce hypometabolism in mice. Biological effects of H2S in in vitro systems are augmented by lowering O2 tension. Based on this, we hypothesized that reduced O2 tension would increase H2S-mediated hypometabolism in vivo. To test this, male...http://www.medconnect.com.my/tabid/100/ct9/c458122/Metabolic-and-cardiac-signaling-effects-of-inhaled-hydrogen-sulfide-and/Default.aspx15-May-2012 During methacholine challenge tests of airway responsiveness, it is invariably assumed that the administered dose of agonist is accurately reflected in the dose that eventually reaches the airway smooth muscle (ASM). However, agonist must traverse a variety of tissue obstacles to reach the ASM,...http://www.medconnect.com.my/tabid/100/ct9/c458123/Airway-responsiveness-depends-on-the-diffusion-rate-of-methacholine-across/Default.aspx15-May-2012 Acute intermittent hypoxia [AIH; 3, 5-min episodes; 35–45 mmHg arterial Po2 (PaO2)] elicits serotonin-dependent phrenic long-term facilitation (pLTF), a form of phrenic motor facilitation (pMF) initiated by Gq protein-coupled metabotropic 5-HT2 receptors. An alternate pathway to pMF is...http://www.medconnect.com.my/tabid/100/ct9/c458124/Severe-acute-intermittent-hypoxia-elicits-phrenic-long-term-facilitation-by/Default.aspx15-May-2012 Before a bolus is pushed into the pharynx, oral sensory processing is critical for planning movements of the subsequent pharyngeal swallow, including hyoid bone and laryngeal (hyo-laryngeal) kinematics. However, oral and pharyngeal sensory processing for hyo-laryngeal kinematics is not fully...http://www.medconnect.com.my/tabid/100/ct9/c458125/Adaptation-of-swallowing-hyo-laryngeal-kinematics-is-distinct-in-oral/Default.aspx15-May-2012 Intermittent hypoxia (IH) conditioning minimizes neurocognitive impairment and stabilizes brain mitochondrial integrity during ethanol withdrawal (EW) in rats, but the mitoprotective mechanism is unclear. We investigated whether IH conditioning protects a key mitochondrial enzyme, cytochrome c...http://www.medconnect.com.my/tabid/100/ct9/c458126/Intermittent-hypoxia-conditioning-protects-mitochondrial-cytochrome-c-oxidase-of/Default.aspx15-May-2012 Little is known about the role of Ca2+ in central chemosensitive signaling. We use electrophysiology to examine the chemosensitive responses of tetrodotoxin (TTX)-insensitive oscillations and spikes in neurons of the locus ceruleus (LC), a chemosensitive region involved in respiratory control. We...http://www.medconnect.com.my/tabid/100/ct9/c458127/Postnatal-development-and-activation-of-L-type-Ca2-currents-in/Default.aspx15-May-2012 The onset of nonpulsatile cardiopulmonary bypass is known to deteriorate microcirculatory perfusion, but it has never been investigated whether this may be prevented by restoration of pulsatility during extracorporeal circulation. We therefore investigated the distinct effects of nonpulsatile and...http://www.medconnect.com.my/tabid/100/ct9/c458128/Pulsatile-flow-during-cardiopulmonary-bypass-preserves-postoperative-microcirculatory/Default.aspx15-May-2012 This study examined the effectiveness of a short-duration but high-intensity exercise countermeasure in combination with a novel oral volume load in preventing bed rest deconditioning and orthostatic intolerance. Bed rest reduces work capacity and orthostatic tolerance due in part to cardiac...http://www.medconnect.com.my/tabid/100/ct9/c458129/Effect-of-rowing-ergometry-and-oral-volume-loading-on/Default.aspx15-May-2012 Renal microvascular (MV) damage and loss contribute to the progression of renal injury in renovascular disease (RVD). Whether a targeted intervention in renal microcirculation could reverse renal damage is unknown. We hypothesized that intrarenal vascular endothelial growth factor (VEGF) therapy...http://www.medconnect.com.my/tabid/100/ct9/c457817/Reversal-of-renal-dysfunction-by-targeted-administration-of-VEGF/Default.aspx15-May-2012 We tested the effects of insulin (2 nM, 30–60 min) on principal cells of isolated split-open rat cortical collecting ducts (CCD) using whole-cell current measurements. Insulin addition to the superfusate of the tubules enhanced Na pump (ouabain-sensitive) current from 18 ± 3 to 31...http://www.medconnect.com.my/tabid/100/ct9/c457792/Effects-of-insulin-on-Na-and-K-transporters-in-the-rat-CCD/Default.aspx15-May-2012 Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease characterized by massive enlargement of fluid-filled cysts in the kidney. However, there is no effective therapy yet for this disease. To examine whether ginkgolide B, a natural compound, inhibits cyst development,...http://www.medconnect.com.my/tabid/100/ct9/c457794/Ginkgolide-B-inhibits-renal-cyst-development-in-in-vitro-and-in-vivo-cyst-models/Default.aspx15-May-2012 Renal expression of the klotho gene is markedly suppressed in chronic kidney disease (CKD). Since renal fibrosis is the final common pathology of CKD, we tested whether decreased Klotho expression is a cause and/or a result of renal fibrosis in mice and cultured renal cell lines. We induced renal...http://www.medconnect.com.my/tabid/100/ct9/c457798/Reduced-Klotho-expression-level-in-kidney-aggravates-renal-interstitial-fibrosis/Default.aspx15-May-2012 CD151, a member of the tetraspanin family of membrane proteins, is crucially involved in the formation of the glomerular filtration barrier in humans and mice. However, the role of CD151 in podocytes has not been investigated so far. In the present study, we utilized a conditionally immortalized...http://www.medconnect.com.my/tabid/100/ct9/c457800/Morphology-and-migration-of-podocytes-are-affected-by-CD151-levels/Default.aspx15-May-2012 The salt intake of an organism controls the number of renin-producing cells in the kidney by yet undefined mechanisms. This study aimed to assess a possible mediator role of preglomerular blood pressure in the control of renin expression by oral salt intake. We used wild-type (WT) mice and mice...http://www.medconnect.com.my/tabid/100/ct9/c457802/Role-of-blood-pressure-in-mediating-the-influence-of/Default.aspx15-May-2012 Preterm neonates are commonly exposed postnatally to pharmacological treatments for a patent ductus arteriosus. Exposure of the developing kidney to nephrotoxic medications may adversely impact renal development. This study aimed to determine the effect of early postnatal ibuprofen treatment, both...http://www.medconnect.com.my/tabid/100/ct9/c457804/Effects-of-ibuprofen-treatment-on-the-developing-preterm-baboon-kidney/Default.aspx15-May-2012 Tubular secretion of the organic cation, creatinine, limits its value as a marker of glomerular filtration rate (GFR) but the molecular determinants of this pathway are unclear. The organic anion transporters, OAT1 and OAT3, are expressed on the basolateral membrane of the proximal tubule and...http://www.medconnect.com.my/tabid/100/ct9/c457806/A-role-for-the-organic-anion-transporter-OAT3-in-renal-creatinine-secretion-in-mice/Default.aspx15-May-2012 Tubuloglomerular feedback (TGF) and connecting tubule glomerular feedback (CTGF) are mechanisms that control afferent arteriole (Af-Art) tone. TGF, initiated by increased NaCl at the macula densa, causes Af-Art constriction. Prolonged activation of TGF leads to an attenuation or "resetting" of its...http://www.medconnect.com.my/tabid/100/ct9/c457808/Connecting-tubule-glomerular-feedback-mediates-acute-tubuloglomerular-feedback/Default.aspx15-May-2012 Endothelial progenitor cells (EPCs) protect the kidney from acute ischemic injury. The aim of this study was to analyze whether pretreatment of murine "early outgrowth" EPCs (eEPCs) with the hormone melatonin increases the cells' renoprotective effects in the setting of murine acute ischemic renal...http://www.medconnect.com.my/tabid/100/ct9/c457810/The-hormone-melatonin-stimulates-renoprotective-effects-of-early-outgrowth-/Default.aspx15-May-2012 Arap1 is a protein that interacts with angiotensin II type 1 (AT1) receptors and facilitates increased AT1 receptor surface expression in vitro. In the present study, we assessed the tissue localization and regulation of Arap1 in vivo. Arap1 was found in various mouse organs, with the highest...http://www.medconnect.com.my/tabid/100/ct9/c457811/Angiotensin-AT1-receptor-associated-protein-Arap1-in-the-kidney-vasculature/Default.aspx15-May-2012 Collecting duct (CD) endothelin-1 (ET-1) is an important autocrine inhibitor of Na and water transport. CD ET-1 production is stimulated by extracellular fluid volume expansion and tubule fluid flow, suggesting a mechanism coupling CD Na delivery and ET-1 synthesis. A mouse cortical CD cell line,...http://www.medconnect.com.my/tabid/100/ct9/c457814/Na-delivery-and-ENaC-mediate-flow-regulation-of-collecting/Default.aspx15-May-2012A 39 year old woman started injecting heroin when she was 18 but soon found she could not control her drug intake or her life in general. At age 30, she sought help and did well with methadone... http://www.medconnect.com.my/tabid/100/ct9/c457734/Maintenance-drugs-to-treat-opioid-dependence/Default.aspx15-May-2012Sinha and colleagues’ audit of the recording of patients’ hearing status in a hospital elderly care department is encouraging.1 If other teams followed their example, the benefits to patients could... http://www.medconnect.com.my/tabid/100/ct9/c457736/Action-on-Hearing-Loss-needs-your-support/Default.aspx15-May-2012We agree that the fingertip unit is useful,1 but it covers twice the area of a handprint (adult palm plus fingers),2 not twice the area of the palm alone as Reddy and colleagues’ suggest.A fingertip... http://www.medconnect.com.my/tabid/100/ct9/c457738/Defining-the-fingertip-unit/Default.aspx15-May-2012Objective To examine the effectiveness of post-diagnosis dementia treatment and coordination of care by memory clinics compared with general practitioners.Design Multicentre randomised controlled... http://www.medconnect.com.my/tabid/100/ct9/c457740/Effectiveness-of-dementia-follow-up-care-by-memory-clinics-or/Default.aspx15-May-2012Executive summaryThe India-UK CEO Forum was established by the British and Indian prime ministers in July 2010 to seek to increase substantially trade and investment between the UK and India and... http://www.medconnect.com.my/tabid/100/ct9/c457742/Strengthening-primary-healthcare-in-India-white-paper-on-opportunities/Default.aspx15-May-2012A 60 year old woman presented to the chest clinic with four years of worsening dyspnoea. On waking she felt unrefreshed and had a headache. She felt sleepy throughout the day. Her medical history... http://www.medconnect.com.my/tabid/100/ct9/c457744/A-64-year-old-woman-with-headache-and-breathlessness/Default.aspx15-May-2012Six of the 10 authors of the study of salt levels in fast foods across six countries, reported by Roehr,1 are members of WASH (World Action on Salt and Health). The singular goal of WASH is the... http://www.medconnect.com.my/tabid/100/ct9/c457746/The-risks-of-reducing-current-salt-levels/Default.aspx15-May-2012An important policy change announcement in the US coincided with publication of my article on investigating pregnant women exposed to a child with a rash.1 I stated: “The recommended time frame for... http://www.medconnect.com.my/tabid/100/ct9/c457748/Policy-change-on-VZIG-in-the-US-to-match-UK-recommendations/Default.aspx15-May-2012Spence’s article is based on the misleading claim that health promotion in England costs £3.7bn (€4.6bn; $6bn) a year.1 This figure is taken from table 3 of the 2009 NHS Public Health and Expenditure... http://www.medconnect.com.my/tabid/100/ct9/c457750/We-need-to-move-away-from-relying-on-drugs/Default.aspx15-May-2012Hanning and Evans, who declare histories of anti-wind farm activity, say that a large body of evidence now exists that wind turbines within permissible distances from housing disturb sleep and impair... http://www.medconnect.com.my/tabid/100/ct9/c457752/Editorial-ignored-17-reviews-on-wind-turbines-and-health/Default.aspx15-May-2012As McCartney points out,1 screening for group B streptococcus at 35-37 weeks of pregnancy omits the preterm babies most at risk of the infection. An additional problem is that carriage of the... http://www.medconnect.com.my/tabid/100/ct9/c457754/Time-for-rapid-testing-for-streptococcus-B-during-labour/Default.aspx15-May-2012Paccaud emphasises economic incentives for new antibiotic discovery to tackle antibiotic resistance.1 An ecological perspective suggests that new drug discovery may not make a major contribution.The... http://www.medconnect.com.my/tabid/100/ct9/c457756/Existing-classes-of-antibiotics-are-probably-the-best-we-will-ever-have/Default.aspx15-May-2012After the recent publication of guidance on collaboration between healthcare professionals and the drug industry,1 the BMJ printed two letters of criticism to which we would like to respond.2 3 This... http://www.medconnect.com.my/tabid/100/ct9/c457758/Towards-greater-transparency-in-the-life-sciences/Default.aspx15-May-2012As the anaesthetist in charge during the operation conducted during a hospital blackout, may I make some corrections?1 Staff did not hand ventilate the patient: the ventilator kept working on battery... http://www.medconnect.com.my/tabid/100/ct9/c457760/Facts-were-not-entirely-correct/Default.aspx15-May-2012Blackouts are common in Greek public hospitals.1 When lights go off in the operating room, during a surgical procedure, the situation is understandably dramatic.A Greek obstetrician at the public... http://www.medconnect.com.my/tabid/100/ct9/c457762/Surgical-application-of-smartphones/Default.aspx15-May-2012We of Group B Strep Support (GBSS) were disappointed that Margaret McCartney reiterated some myths about screening for group B streptococcus during pregnancy.1 We challenge four of her statements.(1)... http://www.medconnect.com.my/tabid/100/ct9/c457764/Group-B-Strep-Support-replies-to-Margaret-McCartney/Default.aspx15-May-2012We read the judgement of the prosecution of the parents of baby Jayden with sadness and interest.1 It is accepted that Jayden had congenital rickets—he was born with it, probably because his mother... http://www.medconnect.com.my/tabid/100/ct9/c457766/Dont-ignore-preventive-message-of-baby-Jaydens-case/Default.aspx15-May-2012The concept of primary healthcare was brought to the world’s attention in a consolidated manner by the Declaration of Alma-Ata in 1978.1 This asserted that the overall wellbeing of all people could... http://www.medconnect.com.my/tabid/100/ct9/c457767/Strengthening-primary-healthcare-in-India/Default.aspx15-May-2012Concerned by the emerging threat that resistance to insecticides poses to programmes to control malaria vectors, the World Health Organization this week launched a new global plan for insecticide... http://www.medconnect.com.my/tabid/100/ct9/c457769/Insecticide-resistance-threatens-malaria-control-programmes-WHO-says/Default.aspx15-May-2012Some newspapers and commentators have a surgical knife out to stick into the National Health Service, and particularly into doctors. These newspapers tend to be on the political right, and their... http://www.medconnect.com.my/tabid/100/ct9/c457770/Medicine-is-our-vocation/Default.aspx15-May-2012Health ministers from the four countries of the United Kingdom have launched a consultation on what system food manufacturers should use to show consumers the nutritional content of products.The move... http://www.medconnect.com.my/tabid/100/ct9/c457772/EU-law-forces-UK-ministers-to-rethink-food-labelling/Default.aspx15-May-2012This article originally appeared in Le MondeCanadaArcticPolar regionsAnne Pélouasguardian.co.uk © 2012 Guardian News and Media Limited or its affiliated companies. All rights reserved. | Use of this content is subject to our Terms & Conditions | More Feeds (Source: Guardian Unlimited...http://www.medconnect.com.my/tabid/100/ct9/c459167/Resolute-explorers-of-the-Arctic/Default.aspx15-May-2012Drink lots of water (Source: Primary Care News - Doctors Lounge)MedWorm Sponsor Message: Please have a look at this new site driven by MedWorm: The Breast Cancer Dailyhttp://www.medconnect.com.my/tabid/100/ct9/c458140/Health-Tip-Exercising-in-the-Heat/Default.aspx15-May-2012[Daily Trust] Awka - Anambra State Governor Peter obi has said that the state will remain polio-free as his government is determined to ensure that the disease does not surface in the state. He said this yesterday during a campaign for the eradication of polio. Obi, who was accompanied by his...http://www.medconnect.com.my/tabid/100/ct9/c458141/Nigeria-Anambra-Will-Remain-Polio-Free-Says-Obi/Default.aspx15-May-2012 All mammalian cells express 3 closely related Ras proteins, termed H-Ras, K-Ras, and N-Ras, that promote oncogenesis when they are mutationally activated at codon 12, 13, or 61. Although there is a high degree of similarity among the isoforms, K-Ras mutations are far more frequently observed in...http://www.medconnect.com.my/tabid/100/ct9/c457617/A-Comprehensive-Survey-of-Ras-Mutations-in-Cancer/Default.aspx15-May-2012 Tumors exhibit metabolic reprogramming characterized by increased cellular reactive oxygen species (ROS) and the preferential use of glucose, which is known as the Warburg effect. However, the mechanisms by which these processes are linked remain largely elusive. Murine tumors lacking Sirt3...http://www.medconnect.com.my/tabid/100/ct9/c457621/SIRT3-Is-a-Mitochondrial-Tumor-Suppressor-A-Scientific-Tale/Default.aspx15-May-2012 The tumor microenvironment (TME) consists of cells, soluble factors, signaling molecules, extracellular matrix, and mechanical cues that can promote neoplastic transformation, support tumor growth and invasion, protect the tumor from host immunity, foster therapeutic resistance, and provide niches...http://www.medconnect.com.my/tabid/100/ct9/c457622/Tumor-Microenvironment-Complexity-Emerging-Roles-in-Cancer-Therapy/Default.aspx15-May-2012 Pancreatic cancer is an aggressive disease with poor prognosis, due, in part, to the lack of disease-specific biomarkers that could afford early and accurate diagnosis. With a recombinant antibody microarray platform, targeting mainly immunoregulatory proteins, we screened sera from 148 patients...http://www.medconnect.com.my/tabid/100/ct9/c457623/Identification-of-Serum-Biomarker-Signatures-Associated-with-Pancreatic-Cancer/Default.aspx15-May-2012 Raman spectroscopy is a noninvasive optical technique capable of measuring vibrational modes of biomolecules within viable tissues. In this study, we evaluated the application of an integrated real-time system of Raman spectroscopy for in vivo skin cancer diagnosis. Benign and malignant skin...http://www.medconnect.com.my/tabid/100/ct9/c457625/Real-time-Raman-Spectroscopy-for-In-Vivo-Skin-Cancer-Diagnosis/Default.aspx15-May-2012 Driver tyrosine kinase mutations are rare in sarcomas, and patterns of tyrosine phosphorylation are poorly understood. To better understand the signaling pathways active in sarcoma, we examined global tyrosine phosphorylation in sarcoma cell lines and human tumor samples. Anti-phosphotyrosine...http://www.medconnect.com.my/tabid/100/ct9/c457628/Phosphoproteomics-Identifies-Driver-Tyrosine-Kinases-in-Sarcoma-Cell-Lines-and-Tumors/Default.aspx15-May-2012 Gastric cancer is the most common cancer in Asia and most developing countries. Despite the use of multimodality therapeutics, it remains the second leading cause of cancer death in the world. To identify the molecular underpinnings of gastric cancer in the Asian population, we applied an...http://www.medconnect.com.my/tabid/100/ct9/c457629/AMPK{alpha}-Modulation-in-Cancer-Progression-Multilayer-Integrative-Analysis-of/Default.aspx15-May-2012 A number of cancers predominantly metastasize to bone, due to its complex microenvironment and multiple types of constitutive cells. Prostate cancer especially has been shown to localize preferentially to bones with higher marrow cellularity. Using an experimental prostate cancer metastasis model,...http://www.medconnect.com.my/tabid/100/ct9/c457630/Cyclophosphamide-Creates-a-Receptive-Microenvironment-for-Prostate-Cancer-Skeletal/Default.aspx15-May-2012 Many solid malignant tumors arise on a background of inflamed and/or fibrotic tissues, features that are found in more than 80% hepatocellular carcinomas (HCC). Activated hepatic stellate cells (HSC) play a critical role in fibrogenesis associated with HCC onset and progression, yet their...http://www.medconnect.com.my/tabid/100/ct9/c457633/Hepatocyte-Stellate-Cell-Cross-Talk-in-the-Liver-Engenders-a-Permissive/Default.aspx15-May-2012 Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor, and the gene is frequently targeted by deletion and inactivation in human malignant tumors. Here, we...http://www.medconnect.com.my/tabid/100/ct9/c457635/Parkin-Pathway-Activation-Mitigates-Glioma-Cell-Proliferation-and-Predicts/Default.aspx15-May-2012 Early biomarkers and effective therapeutic strategies are desperately needed to treat pancreatic ductal adenocarcinoma (PDAC), which has a dismal 5-year patient survival rate. Here, we report that the novel tyrosine kinase PEAK1 is upregulated in human malignancies, including human PDACs and...http://www.medconnect.com.my/tabid/100/ct9/c457636/KRas-Induces-a-Src-PEAK1-ErbB2-Kinase-Amplification-Loop-That-Drives/Default.aspx15-May-2012 Perturbations in the composition and assembly of extracellular matrices (ECM) contribute to progression of numerous diseases, including cancers. Anchoring of laminins at the cell surface enables assembly and signaling of many ECMs, but the possible contributions of altered laminin anchoring to...http://www.medconnect.com.my/tabid/100/ct9/c457638/Loss-of-Cell-Surface-Laminin-Anchoring-Promotes-Tumor-Growth-and/Default.aspx15-May-2012 The contributions of interleukin (IL)-17 to cancer remain unclear and somewhat controversial. We took a genetic approach to explore its role in prostate cancers by interbreeding IL-17 receptor C (IL-17RC)–deficient mice with mice that are conditionally mutant for PTEN, one established preclinical...http://www.medconnect.com.my/tabid/100/ct9/c457641/Interleukin-17-Promotes-Formation-and-Growth-of-Prostate-Adenocarcinoma-in/Default.aspx15-May-2012 In an effort to develop cancer therapies that maximize cytotoxicity, while minimizing unwanted side effects, we studied a series of novel compounds based on the highly energetic heterocyclic scaffold, dinitroazetidine. In this study, we report the preclinical validation of...http://www.medconnect.com.my/tabid/100/ct9/c457642/Dinitroazetidines-Are-a-Novel-Class-of-Anticancer-Agents-and/Default.aspx15-May-2012 Although oncolytic virotherapy is a promising anticancer therapy, antitumor efficacy is hampered by low tumor selectivity. To identify a potent and selective oncolytic virotherapy, we carried out large-scale two-step screening of 28 enteroviral strains and found that coxsackievirus B3 (CVB3)...http://www.medconnect.com.my/tabid/100/ct9/c457643/Coxsackievirus-B3-Is-an-Oncolytic-Virus-with-Immunostimulatory-Properties/Default.aspx15-May-2012 Melanomas and other cancers that do not express argininosuccinate synthetase (AS), the rate-limiting enzyme for arginine biosynthesis, are sensitive to arginine depletion with pegylated arginine deiminase (ADI-PEG20). However, ADI resistance eventually develops in tumors because of AS...http://www.medconnect.com.my/tabid/100/ct9/c457646/Activation-of-Ras-PI3K-ERK-Pathway-Induces-c-Myc-Stabilization-to-Upregulate/Default.aspx15-May-2012 Cancer cells are long known to exhibit increased aerobic glycolysis, but glycolytic inhibition has not offered a viable chemotherapeutic strategy in part because of the systemic toxicity of antiglycolytic agents. However, recent studies suggest that a combined inhibition of glycolysis and...http://www.medconnect.com.my/tabid/100/ct9/c457647/Mitochondria-Targeted-Drugs-Synergize-with-2-Deoxyglucose-to-Trigger-Breast-Cancer/Default.aspx15-May-2012 Despite intensive treatment regimens, high-risk and late-stage neuroblastoma tends to have a poor survival outcome. Overexpression of the apoptotic regulator, X-linked inhibitor of apoptosis protein (XIAP), has been associated with chemotherapy resistance in several cancers including...http://www.medconnect.com.my/tabid/100/ct9/c457651/Smac-Mimetic-LBW242-Sensitizes-XIAP-Overexpressing-Neuroblastoma-Cells-for/Default.aspx15-May-2012 EGFRvIII is a tumor-specific variant of the epidermal growth factor receptor (EGFR). Although EGFRvIII is most commonly found in glioblastoma, its expression in other tumor types remains controversial. In this study, we investigated EGFRvIII expression and amplification in primary breast...http://www.medconnect.com.my/tabid/100/ct9/c457652/Epidermal-Growth-Factor-Receptor-Variant-III-Contributes-to-Cancer/Default.aspx15-May-2012 Increasing evidence suggests that HER2-amplified breast cancer cells use HER3/ErbB3 to drive therapeutic resistance to HER2 inhibitors. However, the role of ErbB3 in the earliest events of breast epithelial transformation remains unknown. Using mouse mammary specific models of Cre-mediated ErbB3...http://www.medconnect.com.my/tabid/100/ct9/c457653/HER3-Is-Required-for-HER2-Induced-Preneoplastic-Changes-to-the/Default.aspx15-May-2012 The fate of circulating tumor cells (CTC) is an important determinant of metastasis and recurrence, which leads to most deaths in hepatocellular carcinoma (HCC). Therefore, quantification of CTCs proves to be an emerging tool for diagnosing, stratifying, and monitoring patients with metastatic...http://www.medconnect.com.my/tabid/100/ct9/c457656/Real-Time-Monitoring-of-Rare-Circulating-Hepatocellular-Carcinoma-Cells-in/Default.aspx15-May-2012Updated Date: May 15, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))http://www.medconnect.com.my/tabid/100/ct9/c459168/PARROT-HEAD-FINS-UP-SPORT-30-Avobenzone-Homosalate-Octisalate-Octocrylene-/Default.aspx15-May-2012Updated Date: May 15, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))MedWorm Sponsor Message: Please have a look at this new site driven by MedWorm: The Breast Cancer Dailyhttp://www.medconnect.com.my/tabid/100/ct9/c459169/PARROT-HEAD-FINS-UP-SPORT-30-MIST-Avobenzone-Homosalate-/Default.aspx15-May-2012Updated Date: May 15, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))http://www.medconnect.com.my/tabid/100/ct9/c459170/PARROT-HEAD-FINS-UP-SPORT-15-Avobenzone-Homosalate-Octisalate-Lotion/Default.aspx15-May-2012Conclusions: Despite successful training, critical procedural errors can still be made by patients on homehemodialysis. In this case, the error involved misconnection of the saline bag for wash back.This case should prompt providers of home hemodialysis to review their training protocolsand...http://www.medconnect.com.my/tabid/100/ct9/c458690/Exsanguination-of-a-home-hemodialysis-patient-as-a-result-of-misconnected/Default.aspx15-May-2012In conclusion, although the response to exercise training remains intact, early exercise training in rats born small does not have a reprogramming effect to prevent deficits in skeletal muscle markers of mitochondrial biogenesis in adulthood. (Source: AJP: Endocrinology and Metabolism)http://www.medconnect.com.my/tabid/100/ct9/c458142/Exercise-early-in-life-in-rats-born-small-does/Default.aspx15-May-2012Elevated sympathetic outflow and altered autonomic reflexes, including impaired baroreflex function, are common findings observed in hypertensive disorders. Although a growing body of evidence supports a contribution of preautonomic neurons in the hypothalamic paraventricular nucleus (PVN) to...http://www.medconnect.com.my/tabid/100/ct9/c458143/Exercise-training-normalizes-an-increased-neuronal-excitability-of-NTS-projecting/Default.aspx15-May-2012During exercise, contracting muscles can override sympathetic vasoconstrictor activity (functional sympatholysis). ATP and adenosine have been proposed to play a role in skeletal muscle blood flow regulation. However, little is known about the role of muscle training status on functional...http://www.medconnect.com.my/tabid/100/ct9/c458144/Two-weeks-of-muscle-immobilization-impairs-functional-sympatholysis-but/Default.aspx15-May-2012Conclusions:EIPAH is characterized by a decreased ventilatory efficiency due to ventilation to perfusion inequalities. CPET may be useful for the identification of EIPAH and serve to diagnose PAH at an early stage.Drs. Schwaiblmair, von Scheidt, and Berghaus conceived and designed the study. Drs....http://www.medconnect.com.my/tabid/100/ct9/c458145/Detection-of-Exercise-Induced-Pulmonary-Arterial-Hypertension-by-Cardiopulmonary/Default.aspx15-May-2012(Source: Physician's First Watch current issue)http://www.medconnect.com.my/tabid/100/ct9/c458147/Exercise-Testing-in-Asymptomatic-Patients-After-Revascularization-Worth-the-Effort-/Default.aspx15-May-2012Authors: R E Cowan, M S Nash & K D Anderson (Source: Spinal Cord)http://www.medconnect.com.my/tabid/100/ct9/c458148/Exercise-participation-barrier-prevalence-and-association-with-exercise-participation/Default.aspx15-May-2012CONCLUSIONS: LC pelvic fractures represent a heterogeneous group of injuries with a wide range of associated fracture patterns. In particular, there is a wide range of fracture types represented by injuries classified as LC1 (involving any sacral fracture). Fractures with more complex sacral...http://www.medconnect.com.my/tabid/100/ct9/c458759/What-Are-the-Patterns-of-Injury-and-Displacement-Seen/Default.aspx15-May-2012CONCLUSIONS: Our results are superior to those of other implants and support continued use of this implant. Studies with longer followup are required to confirm these results. LEVEL OF EVIDENCE: Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of...http://www.medconnect.com.my/tabid/100/ct9/c458762/A-Promising-Thumb-Basal-Joint-Hemiarthroplasty-for-Treatment-of/Default.aspx15-May-2012CONCLUSIONS: Cementation of a liner into a well-fixed cementless shell after scoring in a spider-web configuration provided secure fixation with no failures of the construct at average 5.3 years followup. LEVEL OF EVIDENCE: Level IV, therapeutic study. See Guidelines for Authors for a complete...http://www.medconnect.com.my/tabid/100/ct9/c458765/Cementing-Acetabular-Liners-Into-Secure-Cementless-Shells-for-Polyethylene/Default.aspx15-May-2012CONCLUSIONS: C2DA inhibited biofilm formation by MRSA at biocompatible concentrations, with increasing biofilm reduction with added antibiotics. Elution of C2DA from a chitosan sponge can be modified through adjusting loading concentration. CLINICAL RELEVANCE: By inhibiting biofilm formation on...http://www.medconnect.com.my/tabid/100/ct9/c458768/Cis-2-decenoic-Acid-Inhibits-S-aureus-Growth-and-Biofilm-In-Vitro-A-Pilot-Study-/Default.aspx15-May-2012CONCLUSIONS: One- and two-screw fixation for Type II dens fractures provide similar stability but neither restores normal shear or torsional stiffness. CLINICAL RELEVANCE: One-screw fixation might be used as an alternative to two-screw fixation. Assumed BMD should not influence surgical decision...http://www.medconnect.com.my/tabid/100/ct9/c458770/One-Screw-Fixation-Provides-Similar-Stability-to-That-of-Two-Screw/Default.aspx15-May-2012Study shows improvements in dyspneaRelated items from OnMedicaRegulation of acupuncture, herbal and Chinese medicine Acupuncture could ease nerve pain of cancer treatmentReliable test for COPD exacerbationsAction plan launched on COPDLack of exercise for children with asthma (Source: OnMedica...http://www.medconnect.com.my/tabid/100/ct9/c459171/Acupuncture-may-benefit-COPD-patients/Default.aspx15-May-2012In non-diabetic adult patients, hypoglycaemia may be related to drugs, critical illness, cortisol or glucagon insufficiency, non-islet cell tumour, insulinoma, or it may be surreptitious. Nevertheless, some hypoglycaemic episodes remain unexplained, and inborn errors of metabolism (IEM) should be...http://www.medconnect.com.my/tabid/100/ct9/c459172/Hypoglycaemia-related-to-inherited-metabolic-diseases-in-adults/Default.aspx15-May-2012Aging is associated with a functional decline of the oxidative metabolism due to progressive limitations of both O2 delivery and utilization. Priming exercise (PE) increases the speed of adjustment of oxidative metabolism during successive moderate-intensity transitions. We tested the hypothesis...http://www.medconnect.com.my/tabid/100/ct9/c459173/Effects-of-priming-exercise-on-the-speed-of-adjustment-of/Default.aspx15-May-2012The purpose of this study was to elucidate the influence of inspiratory muscle fatigue on muscle sympathetic nerve activity (MSNA) and blood pressure (BP) response during submaximal exercise. We hypothesized that inspiratory muscle fatigue would elicit increases in sympathetic vasoconstrictor...http://www.medconnect.com.my/tabid/100/ct9/c459174/Inspiratory-muscle-fatigue-increases-sympathetic-vasomotor-outflow-and-blood-pressure/Default.aspx15-May-2012(Source: Journal of Applied Physiology)http://www.medconnect.com.my/tabid/100/ct9/c459175/What-does-the-transcriptome-signature-of-resistance-exercise-tell/Default.aspx15-May-2012 Background: Improving a patient's ability to self-monitor and manage changes in chronic obstructive pulmonary disease (COPD) symptoms may improve outcomes. Objective: To determine the efficacy of a comprehensive care management program (CCMP) in reducing the risk for COPD...http://www.medconnect.com.my/tabid/100/ct9/c457338/A-Comprehensive-Care-Management-Program-to-Prevent-Chronic-Obstructive/Default.aspx15-May-2012 Background: Colon screening by optical colonoscopy (OC) or computed tomographic colonography (CTC) requires a laxative bowel preparation, which inhibits screening participation. Objective: To assess the performance of detecting adenomas 6 mm or larger and patient experience of laxative-free,...http://www.medconnect.com.my/tabid/100/ct9/c457340/Diagnostic-Accuracy-of-Laxative-Free-Computed-Tomographic-Colonography-for-Detection/Default.aspx15-May-2012 Background: The risk for colorectal cancer (CRC) is unclear for persons who have first-degree relatives with adenomatous polyps (adenomas). Purpose: To determine the validity of studies about this issue. Data Sources: MEDLINE and Cochrane databases from 1966 through 2011. Study...http://www.medconnect.com.my/tabid/100/ct9/c457342/Risk-for-Colorectal-Cancer-in-Persons-With-a-Family/Default.aspx15-May-2012 Background: Thromboembolic disease is the most frequent medical complication of arthroplasty. Purpose: To evaluate the benefits and harms of oral direct factor Xa inhibitors versus low-molecular-weight heparin (LMWH) in patients undergoing total hip or knee replacement. Data Sources: MEDLINE...http://www.medconnect.com.my/tabid/100/ct9/c457344/Oral-Direct-Factor-Xa-Inhibitors-Versus-Low-Molecular-Weight-Heparin-to/Default.aspx15-May-2012 Background: The optimal duration of thromboprophylaxis after major orthopedic surgery is unclear. Purpose: To compare the benefits and harms of prolonged versus standard-duration thromboprophylaxis after major orthopedic surgery in adults. Data Sources: Cochrane Central Register of Controlled...http://www.medconnect.com.my/tabid/100/ct9/c457346/Prolonged-Versus-Standard-Duration-Venous-Thromboprophylaxis-in-Major-Orthopedic/Default.aspx15-May-2012 Background: The Department of Health and Human Services recently called for public comment on human subjects research protections. Objective: To assess variability in reviews across institutional review boards (IRBs) for a multisite, minimal-risk trial of financial incentives for evidence-based...http://www.medconnect.com.my/tabid/100/ct9/c457348/How-Variability-in-the-Institutional-Review-Board-Review-Process-Affects/Default.aspx15-May-2012French chief executive moved the company's focus towards higher margin tools for sports medicine and high-tech wound-care products (Source: FT.com - Drugs and Healthcare)http://www.medconnect.com.my/tabid/100/ct9/c458149/Bohuon-clicks-with-Smith-Nephew/Default.aspx15-May-2012In an observational study of asymptomatic patients who had PCI or CABG and then had a treadmill stress echo, the test did identify at-risk patients. But the patients who then went on to have a repeat revascularization procedure did not have improved survival. Exercise testing is costly and not...http://www.medconnect.com.my/tabid/100/ct9/c458151/Stress-echo-in-asymptomatic-patients-after-revascularization-not-worth-it-/Default.aspx15-May-2012 The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the...http://www.medconnect.com.my/tabid/100/ct9/c457031/Stem-Cells-in-Circulation-and-the-Circulation-Subspecialty-Journals/Default.aspx15-May-2012 Background— cGMP phosphodiesterase type 5 protein is upregulated in myocardial hypertrophy. However, it has never been ascertained whether phosphodiesterase type 5 inhibition exerts an antiremodeling effect in nonischemic heart disease in humans. We explored the cardioreparative properties...http://www.medconnect.com.my/tabid/100/ct9/c457035/Chronic-Inhibition-of-cGMP-Phosphodiesterase-5A-Improves-Diabetic-Cardiomyopathy-/Default.aspx15-May-2012 Background— Although surgery is indicated in patients with mitral regurgitation (MR) when left ventricular (LV) end-systolic (LVES) dimension is >40 mm, LV ejection fraction may decrease after mitral valve surgery. We hypothesize that significant LV remodeling before surgery is not...http://www.medconnect.com.my/tabid/100/ct9/c457036/Magnetic-Resonance-Imaging-With-3-Dimensional-Analysis-of-Left-Ventricular-Remodeling/Default.aspx15-May-2012 Background— The purpose of this study was to evaluate the long-term safety of the Igaki-Tamai stent, the first-in-human fully biodegradable coronary stent made of poly-l-lactic acid. Methods and Results— Between September 1998 and April 2000, 50 patients with 63 lesions were treated...http://www.medconnect.com.my/tabid/100/ct9/c457037/Long-Term-10-Years-Clinical-Outcomes-of-First-in-Human-Biodegradable-Poly-l-Lactic/Default.aspx15-May-2012 Background— Pressure overload resulting from aortic stenosis causes maladaptive ventricular and vascular remodeling that can lead to pulmonary hypertension, heart failure symptoms, and adverse outcomes. Retarding or reversing this maladaptive remodeling and its unfavorable hemodynamic...http://www.medconnect.com.my/tabid/100/ct9/c457038/Effects-of-Phosphodiesterase-Type-5-Inhibition-on-Systemic-and-Pulmonary/Default.aspx15-May-2012 Background— Known risk factors for bleeding during anticoagulant treatment are largely the same as those predicting thromboembolic events in patients with atrial fibrillation (AF). Our objective was to investigate how to maximize the likelihood of avoiding both stroke and bleeding. Methods...http://www.medconnect.com.my/tabid/100/ct9/c457032/Net-Clinical-Benefit-of-Warfarin-in-Patients-With-Atrial/Default.aspx15-May-2012 Background— The incidence of sudden cardiac death (SCD) and the management of this risk in patients with asymptomatic preexcitation remain controversial. The purpose of this meta-analysis was to define the incidence of SCD and supraventricular tachycardia in patients with asymptomatic...http://www.medconnect.com.my/tabid/100/ct9/c457033/Risk-of-Arrhythmia-and-Sudden-Death-in-Patients-With/Default.aspx15-May-2012 Background— The liver-secreted protein fetuin-A induces peripheral insulin resistance in vitro. In a pilot study, we observed that higher fetuin-A levels were associated with diabetes mellitus in older persons. However, this finding has not been confirmed in large cohorts. We sought to...http://www.medconnect.com.my/tabid/100/ct9/c457034/Association-of-Fetuin-A-With-Incident-Diabetes-Mellitus-in-Community-Living/Default.aspx15-May-2012 Objectives The purpose of this study was to examine temporal trends in post-percutaneous coronary intervention (PCI) bleeding among patients with elective PCI, unstable angina (UA)/non–ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction...http://www.medconnect.com.my/tabid/100/ct9/c457055/Temporal-Trends-in-and-Factors-Associated-With-Bleeding-Complications/Default.aspx15-May-2012 Objectives The purpose of this study was to determine appropriateness of percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery performed in New York for patients without acute coronary syndrome (ACS) or previous CABG surgery. Background The American College of...http://www.medconnect.com.my/tabid/100/ct9/c457056/Appropriateness-of-Coronary-Revascularization-for-Patients-Without-Acute-Coronary/Default.aspx15-May-2012 Objectives The authors used multidetector computed tomography (MDCT) to study the relation between culprit plaque characteristics and cardiac troponin T (cTnT) elevation after percutaneous coronary intervention (PCI). Background Percutaneous coronary intervention is often complicated by...http://www.medconnect.com.my/tabid/100/ct9/c457057/Impact-of-Coronary-Plaque-Composition-on-Cardiac-Troponin-Elevation/Default.aspx15-May-2012 Objectives The aim of this study was to determine the incidence and clinical characteristics of sudden cardiac death (SCD) in patients with human immunodeficiency virus (HIV) infection. Background As the HIV-infected population ages, cardiovascular disease prevalence and mortality are increasing,...http://www.medconnect.com.my/tabid/100/ct9/c457058/Sudden-Cardiac-Death-in-Patients-With-Human-Immunodeficiency-Virus-Infection/Default.aspx15-May-2012 Objectives This study was designed to compare the accuracy of 64-row contrast computed tomography (CT), invasive cineventriculography (CVG), 2-dimensional echocardiography (2D Echo), and 3-dimensional echocardiography (3D Echo) for left ventricular (LV) function assessment with magnetic resonance...http://www.medconnect.com.my/tabid/100/ct9/c457059/Head-to-Head-Comparison-of-Left-Ventricular-Function-Assessment-with-64-Row/Default.aspx15-May-2012 Objectives The aim of this study was to investigate whether exposure to a range of relatively low concentrations of aged secondhand smoke (SHS), similar to those encountered commonly in the community, would impair endothelial function in a concentration-dependent manner. Background Exposure to...http://www.medconnect.com.my/tabid/100/ct9/c457063/The-Exposure-Dependent-Effects-of-Aged-Secondhand-Smoke-on-Endothelial-Function/Default.aspx15-May-2012 Objectives: Juvenile myoclonic epilepsy (JME) is characterized by myoclonic jerks of the upper limbs, often triggered by cognitive stressors. Here we aim to reconcile this particular seizure phenotype with the known frontal lobe type neuropsychological profile, photosensitivity, hyperexcitable...http://www.medconnect.com.my/tabid/100/ct9/c457375/Altered-microstructural-connectivity-in-juvenile-myoclonic-epilepsy-The-missing-link/Default.aspx15-May-2012 Objective: To assess the relationship between Alzheimer disease (AD)–related pathologic changes in frontal cortical brain biopsy and AD biomarkers in ventricular vs lumbar CSF, and to evaluate the relationships of AD biomarkers in CSF and cortical biopsy with the final clinical diagnosis of...http://www.medconnect.com.my/tabid/100/ct9/c457376/CSF-biomarkers-for-Alzheimer-disease-correlate-with-cortical-brain-biopsy-findings/Default.aspx15-May-2012 Objective: Recommendations for the diagnosis of preclinical Alzheimer disease (AD) have been formulated by a workgroup of the National Institute on Aging and Alzheimer's Association. Three stages of preclinical AD were described. Stage 1 is characterized by abnormal levels of β-amyloid. Stage...http://www.medconnect.com.my/tabid/100/ct9/c457377/Short-term-clinical-outcomes-for-stages-of-NIA-AA-preclinical-Alzheimer-disease/Default.aspx15-May-2012 Objective: To assess the prevalence and comorbid conditions of nocturnal wandering with abnormal state of consciousness (NW) in the American general population. Methods: Cross-sectional study conducted with a representative sample of 19,136 noninstitutionalized individuals of the US general...http://www.medconnect.com.my/tabid/100/ct9/c457378/Prevalence-and-comorbidity-of-nocturnal-wandering-in-the-US-adult-general-population/Default.aspx15-May-2012 Objective: Utilization of postacute care is associated with improved poststroke outcomes. However, more than 20% of American adults under age 65 are uninsured. We sought to determine whether insurance status is associated with utilization and intensity of institutional postacute care among working...http://www.medconnect.com.my/tabid/100/ct9/c457379/Effect-of-insurance-status-on-postacute-care-among-working-age-stroke-survivors/Default.aspx15-May-2012 Objectives: To determine if there are in vivo differences in -aminobutyric acid (GABA) in the motor cortex and subcortical white matter of patients with amyotrophic lateral sclerosis (ALS) compared with healthy controls using proton magnetic resonance spectroscopy (1H-MRS). Methods: In this...http://www.medconnect.com.my/tabid/100/ct9/c457380/Decreased-motor-cortex-{gamma}-aminobutyric-acid-in-amyotrophic-lateral-sclerosis/Default.aspx15-May-2012 Objective: To describe 16 patients with a coincidence of 2 rare diseases: aquaporin-4 antibody (AQP4-Ab)–mediated neuromyelitis optica spectrum disorder (AQP4-NMOSD) and acetylcholine receptor antibody (AChR-Ab)–mediated myasthenia gravis (AChR-MG). Methods: The clinical details and...http://www.medconnect.com.my/tabid/100/ct9/c457381/Myasthenia-gravis-and-neuromyelitis-optica-spectrum-disorder-A-multicenter/Default.aspx15-May-2012 Background: Despite the availability of diagnostic criteria, an overlap between neuromyelitis optica (NMO) and multiple sclerosis (MS) exists, particularly in the early stage of the disease. Objective: To study the value of NMO–immunoglobulin G (IgG) determination in Caucasian patients with...http://www.medconnect.com.my/tabid/100/ct9/c457382/Value-of-NMO-IgG-determination-at-the-time-of-presentation-as-CIS/Default.aspx15-May-2012Jenny Wright, from Leeds, West Yorkshire, faced a ferocious backlash for continuing to run while pregnant, but the proud mother says her newborn is better off as a results of her exercise regime. (Source: the Mail online | Health)MedWorm Sponsor Message: Please have a look at this new site driven...http://www.medconnect.com.my/tabid/100/ct9/c458152/My-perfect-baby-proves-that-jogging-safe-Mother-branded/Default.aspx15-May-2012Even moderate exercise can reduce the risk of high blood pressure in people with a family history of the disease by 26 per cent, say scientists at the University of South Carolina. (Source: the Mail online | Health)http://www.medconnect.com.my/tabid/100/ct9/c458153/Walking-for-up-to-two-and-a-half-hours-a-week-can-reduce-risks-of-hypertension/Default.aspx15-May-2012If you start racing when you are young, will you be slower in middle age than if you started when you were older? (Source: NYT)http://www.medconnect.com.my/tabid/100/ct9/c458155/Personal-Best-Personal-Best-Can-Runners-Have-Too-Many-Miles-on-the-Tires-/Default.aspx15-May-2012Basketball, volleyball, soccer helped young men stave off density loss, study suggests (Source: Orthopedics News - Doctors Lounge)http://www.medconnect.com.my/tabid/100/ct9/c458156/Some-Sports-May-Help-Protect-Men-s-Bones/Default.aspx15-May-2012Tonight at 8 pm, HBO will debut a four-part documentary series, The Weight of the Nation, an unflinching look at the severity of the obesity crisis in America, and its crippling effect on our nation’s health and economy. HBO and the Institute of Medicine of the National Academy of Sciences...http://www.medconnect.com.my/tabid/100/ct9/c458157/Boston-Children-s-expert-appears-in-The-Weight-of-the-Nation-documentary/Default.aspx15-May-2012There is an odd irony associated with the by-now almost ineluctable tie between reinforcement learning's temporal difference learning rule () and the phasic activity of dopamine neurons (). Although temporal difference learning was designed to enable the acquisition of whole sequences of actions...http://www.medconnect.com.my/tabid/100/ct9/c445931/A-Step-by-Step-Guide-to-Dopamine/Default.aspx15-May-2012One of the pivotal diagnostic distinctions in psychiatry is between bipolar disorder and schizophrenia. Manic depressive psychosis was distinguished from psychosis in general in the 19th century and, following Kraepelin's work in the early 20th century, schizophrenia was differentiated in terms of...http://www.medconnect.com.my/tabid/100/ct9/c445932/Functional-Network-Endophenotypes-of-Psychotic-Disorders/Default.aspx15-May-2012 Objective Our objective was to analyze 3-dimensional (3D) blood flow patterns within the total cavopulmonary connection (TCPC) using in vivo phase contrast magnetic resonance imaging (PC MRI). Methods Sixteen single-ventricle patients were prospectively recruited at 2 leading pediatric...http://www.medconnect.com.my/tabid/100/ct9/c457129/Visualization-of-flow-structures-in-Fontan-patients-using-3-dimensional/Default.aspx14-May-2012 Objective The most common reason for late surgical reintervention after repair of complete atrioventricular canal defects is the development of left atrioventricular valve regurgitation. We sought to determine the changes in left atrioventricular valve geometry after surgical repair that may...http://www.medconnect.com.my/tabid/100/ct9/c457131/Changes-in-left-atrioventricular-valve-geometry-after-surgical-repair/Default.aspx14-May-2012 Objective Uncertainty exists among surgeons as to whether minimally invasive esophagectomy (MIE) is a comparable operation to open esophagectomy (OE). The surgical technique and oncologic dissection should not be degraded when using a minimally invasive approach. Methods We reviewed a single...http://www.medconnect.com.my/tabid/100/ct9/c457134/The-use-of-a-tailored-surgical-technique-for-minimally/Default.aspx14-May-2012 Objective Modern series from high-volume esophageal centers report an approximate 40% 5-year survival in patients treated with curative intent and postoperative mortality rates of less than 4%. An objective analysis of factors that underpin current benchmarks within high-volume centers has not...http://www.medconnect.com.my/tabid/100/ct9/c457137/Evolving-progress-in-oncologic-and-operative-outcomes-for-esophageal/Default.aspx14-May-2012 Objective Thoracic surgeons are performing robotic resections for anterior mediastinal tumors; however, tumors located in the posterior and especially the inferior chest can be difficult to approach robotically. The objective of this study was to evaluate the efficacy of the robot for resection of...http://www.medconnect.com.my/tabid/100/ct9/c457139/Operative-techniques-in-robotic-thoracic-surgery-for-inferior-or/Default.aspx14-May-2012 Objective Thoracic empyema in cirrhotic patients is a challenging situation, and the clinical characteristics are rarely reported. The objective of this study was to report the clinical characteristics among this group and to evaluate whether thoracoscopic intervention would affect clinical...http://www.medconnect.com.my/tabid/100/ct9/c457142/Thoracic-empyema-in-patients-with-liver-cirrhosis-Clinical-characteristics/Default.aspx14-May-2012 Objective We used a whole blood assay to characterize the immune system’s response after cardiopulmonary bypass (CPB) in children to identify the risk for postoperative infections. We assessed the impact of CPB on histone methylation as a potential mechanism for altering gene expression...http://www.medconnect.com.my/tabid/100/ct9/c457146/Clinical-implications-and-molecular-mechanisms-of-immunoparalysis-after/Default.aspx14-May-2012 Objective A new strategy of normothermic cardioplegia based on the combination of adenosine and lidocaine (adenocaine; Hibernation Therapeutics Global Ltd, Kilquade, Ireland) achieves nondepolarized arrest at normokalemia. Both adenosine and lidocaine independently inhibit neutrophil...http://www.medconnect.com.my/tabid/100/ct9/c457149/The-nondepolarizing-normokalemic-cardioplegia-formulation-adenosine-lidocaine/Default.aspx14-May-2012 Objective Recent developments in adjunctive therapy have enabled us to remove once-implanted left ventricular assist devices. For successful device removal, appropriate patient selection and precise evaluation of cardiac function are essential. However, with rotary pumps, pump weaning inevitably...http://www.medconnect.com.my/tabid/100/ct9/c457152/Creating-an-ideal-off-test-mode-for-rotary-left-ventricular/Default.aspx14-May-2012 Objective Despite the excellent outcomes in the current era after the Fontan procedure, it continues to have an inherent risk of failure. Cardiac transplantation provides 1 option for treating these patients; however, the indications for, timing of, and outcomes after, transplantation remain...http://www.medconnect.com.my/tabid/100/ct9/c457154/Outcomes-after-transplantation-for-failed-Fontan-A-single-institution-experience/Default.aspx14-May-2012 Objective Axillary intra-aortic balloon pump therapy has been described as a bridge to transplant. Advantages over femoral intra-aortic balloon pump therapy include reduced incidence of infection and enhanced patient mobility. We identified the patients who would benefit most from this therapy...http://www.medconnect.com.my/tabid/100/ct9/c457156/Benefits-of-ambulatory-axillary-intra-aortic-balloon-pump-for-circulatory/Default.aspx14-May-2012 Objective Postoperative bleeding is a major cause of morbidity and mortality after complex aortic surgery. Intraoperative coagulopathy is a well-known culprit in this process. Recombinant activated factor VII is increasingly used for the postoperative management of such bleeding. We report our...http://www.medconnect.com.my/tabid/100/ct9/c457160/Intraoperative-use-of-recombinant-activated-factor-VII-during-complex/Default.aspx14-May-2012 Objectives Optimal brain protection for aortic arch surgery remains unclear. This prospective study examined neurocognitive outcomes in cardiac and thoracic aortic surgical patients, including a small cohort who underwent selective cerebral perfusion. Methods Fifty-seven adult cardiac and...http://www.medconnect.com.my/tabid/100/ct9/c457162/Selective-cerebral-perfusion-for-thoracic-aortic-surgery-Association-with/Default.aspx14-May-2012 Objective Patients recovering from cardiothoracic surgery are known to be at increased risk of heparin-induced thrombocytopenia. Postoperatively, if heparin-induced thrombocytopenia is suspected, heparin is discontinued immediately and an alternative anticoagulant, such as the direct thrombin...http://www.medconnect.com.my/tabid/100/ct9/c457165/Recognition-of-heparin-induced-thrombocytopenia-and-initiation-of-argatroban-therapy/Default.aspx14-May-2012 Objective For aortic arch aneurysms, conventional total arch replacement has been the standard surgical option. In selected high-risk patients, we have attempted less invasive hybrid procedure involving supra-aortic bypass and endovascular stent-graft placement. We review the early and midterm...http://www.medconnect.com.my/tabid/100/ct9/c457103/Less-invasive-surgical-treatment-for-aortic-arch-aneurysms-in/Default.aspx14-May-2012 Objectives Our objective was to compare effectiveness and safety of a simplified approach for removing retroperitoneal tumors with extensive cavoatrial involvement using beating-heart cardiopulmonary bypass (CPB) versus hypothermic circulatory arrest (HCA). Methods From January 1984 to January...http://www.medconnect.com.my/tabid/100/ct9/c457105/Simplified-perfusion-strategy-for-removing-retroperitoneal-tumors-with-extensive/Default.aspx14-May-2012 Objective Ecallantide is a recombinant peptide in the same class as aprotinin that inhibits plasma kallikrein, a major component of the contact coagulation and inflammatory cascades. Therefore, ecallantide was expected to reduce blood loss associated with cardiac surgery requiring cardiopulmonary...http://www.medconnect.com.my/tabid/100/ct9/c457106/A-phase-2-prospective-randomized-double-blind-trial-comparing-the/Default.aspx14-May-2012 Background Aortic valve replacement leads to improvement of coronary flow but not to complete normalization. Coronary hypoperfusion contributes to higher left ventricular mass persistence, arrhythmias, congestive heart failure and sudden death. This prospective study compares 2 similarly sized...http://www.medconnect.com.my/tabid/100/ct9/c457108/Coronary-perfusion-Impact-of-flow-dynamics-and-geometric-design/Default.aspx14-May-2012 Background The CorCap cardiac support device (Acorn Cardiovascular, Inc, St Paul, Minn) is the first device that specifically addresses ventricular remodeling in heart failure by reducing wall stress. We previously reported outcomes from the Acorn randomized trial to a common closing date (22.9...http://www.medconnect.com.my/tabid/100/ct9/c457109/Beneficial-effects-of-the-CorCap-cardiac-support-device-Five-year/Default.aspx14-May-2012 Objectives The purpose of this study was to examine the trends in tricuspid valve surgery over time. Methods We used 10 years (1999-2008) of NIS data to examine the population of patients undergoing tricuspid valve repair or replacement (ICD-9-CM codes 35.14, 35.27, and 35.28). Results We...http://www.medconnect.com.my/tabid/100/ct9/c457110/Tricuspid-valve-surgery-The-past-10-years-from-the-Nationwide/Default.aspx14-May-2012 Objectives Surgical management of tricuspid valve regurgitation mainly consists of tricuspid valve annuloplasty, usually performed with implantation of a rigid ring or a flexible band. Methods We performed a retrospective analysis on 820 patients who underwent tricuspid valve repair between March...http://www.medconnect.com.my/tabid/100/ct9/c457111/Increased-risk-of-dehiscence-after-tricuspid-valve-repair-with/Default.aspx14-May-2012 Objective The vast majority of reports describing beating heart robotic myocardial revascularization (total endoscopic coronary artery bypass) contain very small numbers of patients undergoing single-vessel bypass. We present a large series of patients undergoing multivessel total endoscopic...http://www.medconnect.com.my/tabid/100/ct9/c457112/Multivessel-beating-heart-robotic-myocardial-revascularization-increases-morbidity/Default.aspx14-May-2012 Objective Reoperative sternotomy to address mitral valve pathology carries substantial risk, especially with patent bypass grafts or an aortic valve prosthesis. We previously reported our early experience with minimally invasive right thoracotomy and peripheral cannulation as an alternative...http://www.medconnect.com.my/tabid/100/ct9/c457115/Fifteen-year-experience-with-minimally-invasive-approach-for-reoperations-involving/Default.aspx14-May-2012 Objective Factors contributing to postoperative complications include blood loss and a heightened inflammatory response. The objective of this study was to test the hypothesis that aprotinin would decrease perioperative blood product use, reduce biomarkers of inflammation, and result in improved...http://www.medconnect.com.my/tabid/100/ct9/c457117/Differential-effects-of-aprotinin-and-tranexamic-acid-on-outcomes/Default.aspx14-May-2012 Objectives We performed a prospective longitudinal study of the neuroanatomic and developmental changes in infants with transposition of the great arteries (TGA) or single-ventricle (SV) physiology to identify variables in anatomic development of the brain associated with functional...http://www.medconnect.com.my/tabid/100/ct9/c457119/The-improvement-of-hypoxia-correlates-with-neuroanatomic-and-developmental/Default.aspx14-May-2012 Objectives A novel Y-shaped baffle has been proposed for the Fontan operation with promising initial results. However, previous studies have relied either on idealized models or a single patient-specific model. The objective of this study is to comprehensively compare the hemodynamic performance...http://www.medconnect.com.my/tabid/100/ct9/c457121/Hepatic-blood-flow-distribution-and-performance-in-conventional-and/Default.aspx14-May-2012 Objective Recurrent aortic arch obstruction after the Norwood procedure continues to be a source of morbidity. We sought to determine if a modified interdigitating technique for aortic arch reconstruction during the Norwood procedure decreased recurrent arch obstruction. Methods A total of 142...http://www.medconnect.com.my/tabid/100/ct9/c457124/Coarctectomy-combined-with-an-interdigitating-arch-reconstruction-results-in/Default.aspx14-May-2012 Objective Chronic pulmonary regurgitation (PR) has deleterious effects on right ventricular (RV) function in repaired tetralogy of Fallot (ToF). However, there are little data regarding right ventricular outflow tract (RVOT) contractile dysfunction in response to chronic PR and on both RV and LV...http://www.medconnect.com.my/tabid/100/ct9/c457126/Long-term-importance-of-right-ventricular-outflow-tract-patch-function/Default.aspx14-May-2012Despite proven benefits of exercise during pregnancy, many still think it will harm their babies. Medscape Medical News (Source: Medscape ObGyn and Womens Health Headlines)MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years...http://www.medconnect.com.my/tabid/100/ct9/c458158/Many-Pregnant-Women-Fear-ExercisingMany-Pregnant-Women-Fear-Exercising/Default.aspx14-May-2012Everyone has frightening or anxious moments. This particular feeling can be detrimental to you because it may stop you from living a normal life.read more (Source: Psychology Today Anxiety Center)http://www.medconnect.com.my/tabid/100/ct9/c458160/Top-10-Tips-to-Reduce-Anxiety/Default.aspx14-May-2012Charities have urged the Global Fund to Fight Aids, Tuberculosis and Malaria to kick start its funding programme after it announced that it has more than $1.6bn (£1bn; €1.2bn) in extra money.In... http://www.medconnect.com.my/tabid/100/ct9/c457298/Reorganisation-at-Global-Fund-sparks-1-6bn-in-new-donations/Default.aspx14-May-2012Patients have a strong desire to engage in shared decision making about treatment with their doctor, but the way the doctor behaves can inhibit this interaction, a new study concludes.The issue is... http://www.medconnect.com.my/tabid/100/ct9/c457299/Old-authoritarian-patterns-of-doctors-behaviour-are-still-alive/Default.aspx14-May-2012Access to healthcare and use of health services for all working age US adults deteriorated from 2000 to 2010, whether they had private insurance, government insurance, or no insurance, says a new... http://www.medconnect.com.my/tabid/100/ct9/c457301/More-Americans-find-healthcare-unattainable-shows-study/Default.aspx14-May-2012Hospital services in Wales need to be reorganised urgently, as some are close to “collapse” despite a decade of improved NHS performance, says an independent review.The report highlights increasing... http://www.medconnect.com.my/tabid/100/ct9/c457303/Hospitals-in-Wales-need-to-reconfigure-to-improve-patient-outcomes-says-report/Default.aspx14-May-2012The days of cheap alcohol being sold in Scotland may soon be over as a minimum price of 50p (€0.6; $0.8) a unit is set to be approved later this month.It will mean that the cheapest bottle of spirits... http://www.medconnect.com.my/tabid/100/ct9/c457305/Cheap-alcohol-is-to-be-outlawed-in-Scotland/Default.aspx14-May-2012A 50 year old right handed man presented with weakness of his right leg and arm of two months’ duration. The symptoms had come on over several days, during which he described a “dead leg” and he... http://www.medconnect.com.my/tabid/100/ct9/c457307/A-weak-leg/Default.aspx14-May-2012Primary dysmenorrhoea is a common, idiopathic, chronic pelvic pain syndrome, but its unknown aetiology prevents targeted treatment. Systematic reviews and randomised controlled trials have shown that... http://www.medconnect.com.my/tabid/100/ct9/c457310/How-effective-are-non-drug-non-surgical-treatments-for-primary-dysmenorrhoea-/Default.aspx14-May-2012A 48 year old man removed two ticks attached to his leg while walking in the Scottish Highlands. A week later he develops a rash and consults you worried about Lyme disease.What you should... http://www.medconnect.com.my/tabid/100/ct9/c457312/Tick-bite-and-early-Lyme-borreliosis/Default.aspx14-May-2012Investigators in randomised clinical trials have a duty to prevent undue hazards for their study patients. To protect patients in trials an independent committee—usually called the data and safety... http://www.medconnect.com.my/tabid/100/ct9/c457314/Keeping-patients-safe-while-avoiding-bias-in-randomised-trials/Default.aspx14-May-2012For a time, the late surgeon Paul Brand was the world’s only orthopaedic surgeon to work with people with leprosy. He was made commander of the order of the British Empire (CBE) in 1961. This book,... http://www.medconnect.com.my/tabid/100/ct9/c457316/Fearfully-and-Wonderfully-Made/Default.aspx14-May-2012Too many Canadians with mental illness receive inadequate or no treatment, and too many end up homeless or incarcerated, says the Mental Health Commission of Canada. On 8 May the commission, which is... http://www.medconnect.com.my/tabid/100/ct9/c457318/Canadas-first-mental-health-strategy-calls-for-ma-jnodot-or-improvements-to-services/Default.aspx14-May-2012Many GPs are failing to discuss dying and end of life wishes with patients, according to a survey commissioned by the Dying Matters Coalition, a group led by the National Council for Palliative... http://www.medconnect.com.my/tabid/100/ct9/c457321/Dying-remains-a-taboo-subject-for-patients-and-GPs-finds-survey/Default.aspx14-May-2012Dr Leila Alice Denmark called her patients “little angels.” She loved being a paediatrician, and she never wanted to stop. But in May 2001 she walked the few steps from her country home to her rustic... http://www.medconnect.com.my/tabid/100/ct9/c457324/Leila-Denmark/Default.aspx14-May-2012The funding allocated to England’s new clinical commissioning groups (CCGs) could be based on the age of their patient population rather than levels of deprivation, the health secretary, Andrew... http://www.medconnect.com.my/tabid/100/ct9/c457327/CCG-funding-could-be-based-on-population-age-not-deprivation-says-Lansley/Default.aspx14-May-2012Diabetes care in England is in a “state of crisis,” with fewer than half of patients receiving even the basic minimum of care, a new report from Diabetes UK warns.The charity’s State of the Nation... http://www.medconnect.com.my/tabid/100/ct9/c457330/More-than-half-of-diabetes-patients-are-not-getting-standard-health-checks/Default.aspx14-May-2012 Non-alcoholic fatty liver disease (NAFLD) affects up to a third of the population worldwide and may confer increased cardiometabolic risk with consequent adverse cardiovascular outcomes independent of traditional cardiovascular risk factors and the metabolic syndrome. It is characterized almost...http://www.medconnect.com.my/tabid/100/ct9/c457073/Non-alcoholic-fatty-liver-disease-a-new-and-important-cardiovascular-risk-factor-/Default.aspx14-May-2012 Deaths from diseases of the heart are decreasing. Cardiovascular diseases (CVD) will be the main cause of morbidity and mortality in 2015 according to a WHO report. The main problem is related to the long-time delay between the start of the development of atherosclerosis in young adults and the...http://www.medconnect.com.my/tabid/100/ct9/c457076/Improvement-of-cardiovascular-risk-prediction-using-coronary-imaging-subclinical/Default.aspx14-May-2012 Aims The efficacy of durable polymer drug-eluting stents (DES) is delivered at the expense of delayed healing of the stented vessel. Biodegradable polymer DES aim to avoid this shortcoming and may potentially improve long-term clinical outcomes, with benefit expected to accrue over time. We sought...http://www.medconnect.com.my/tabid/100/ct9/c457079/Biodegradable-polymer-drug-eluting-stents-reduce-the-risk-of-stent/Default.aspx14-May-2012 Aims Collateral arteries protect tissue from ischaemia. Heart rate correlates with vascular events in patients with arterial obstructive disease. Here, we tested the effect of heart-rate reduction (HRR) on collateral artery growth. Methods and results The If-channel inhibitor ivabradine reduced...http://www.medconnect.com.my/tabid/100/ct9/c457080/Heart-rate-reduction-by-If-channel-inhibition-with-ivabradine-restores-collateral/Default.aspx14-May-2012 Aims To determine the safety and efficacy of a pharmaco-invasive reperfusion strategy utilizing half-dose fibrinolysis combined with transfer for immediate percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients presenting to remote rural hospitals. Primary...http://www.medconnect.com.my/tabid/100/ct9/c457085/Safety-and-efficacy-of-a-pharmaco-invasive-reperfusion-strategy-in-rural/Default.aspx14-May-2012 Aims The aim of this study was to compare on-thienopyridine platelet reactivity of elderly patients (≥75 years) vs. younger patients (<75 years). Elderly patients represent a growing and challenging segment of the coronary population for whom the effect of dual antiplatelet therapy on...http://www.medconnect.com.my/tabid/100/ct9/c457088/High-on-thienopyridine-platelet-reactivity-in-elderly-coronary-patients-the/Default.aspx14-May-2012 Aims To identify the genetic risk factors that influence the development of electrocardiographic (ECG) left ventricular hypertrophy (LVH), a major risk factor for cardiovascular (CV) morbidity and mortality. Methods and results We performed a genomewide association study (GWAS) of ECG-LVH, in...http://www.medconnect.com.my/tabid/100/ct9/c457091/Common-variants-in-RYR1-are-associated-with-left-ventricular/Default.aspx14-May-2012 Aims The benefits of off-pump coronary artery bypass (OPCAB) continue to be debated, in part due to the fact that pooled effects fail to consider differences in trial and patient characteristics. We sought to analyse the contemporary evidence for OPCAB vs. conventional coronary artery bypass...http://www.medconnect.com.my/tabid/100/ct9/c457094/Off-pump-vs-on-pump-coronary-artery-bypass-surgery-an-updated/Default.aspx14-May-2012 Aims Conventional late gadolinium enhancement (LGE) cardiac magnetic resonance can detect myocardial infarction and some forms of non-ischaemic myocardial fibrosis. However, quantitative imaging of extracellular volume fraction (ECV) may be able to detect subtle abnormalities such as diffuse...http://www.medconnect.com.my/tabid/100/ct9/c457097/Extracellular-volume-imaging-by-magnetic-resonance-imaging-provides-insights/Default.aspx14-May-2012 Aims Obesity is commonly associated with hypertension. Increased sympathetic tonus in obese subjects contributes to the underlying mechanism. However, the precise mechanisms whereby obesity induces this sympathetic activation remain unclear. Hepatic peroxisome proliferator-activated receptor...http://www.medconnect.com.my/tabid/100/ct9/c457100/Hepatic-peroxisome-proliferator-activated-receptor-{gamma}-fat-specific-protein-27/Default.aspx14-May-2012Conclusions A short-duration CTCDSP may be an effective, feasible, and favorably received approach to improving diabetes outcomes in Korean and potentially other underserved ethnic minority immigrants who have limited access to mainstream clinic-based diabetes self-management programs. (Source: The...http://www.medconnect.com.my/tabid/100/ct9/c458163/Effect-of-a-Short-Duration-Culturally-Tailored-Community-Based-Diabetes/Default.aspx14-May-2012Conclusions: Alogliptin 12.5 mg and 25 mg once daily was safe and effective when added to metformin (500 mg/day or 750 mg/day) in Japanese patients with inadequately controlled type 2 diabetes on metformin alone. (Source: Diabetes, Obesity and Metabolism)MedWorm Sponsor Message: Please have a look...http://www.medconnect.com.my/tabid/100/ct9/c458164/Efficacy-and-safety-of-alogliptin-added-to-metformin-in-Japanese/Default.aspx14-May-2012Conclusion Only a minority of TIA patients achieved RCP standards whereas QOF standards were generally well achieved. Substantial benefits in terms of stroke prevention stand to be gained if risk factors are managed in line with more stringent RCP standards. (Source: Postgraduate Medical Journal)http://www.medconnect.com.my/tabid/100/ct9/c458165/Quality-of-secondary-prevention-measures-in-TIA-patients-a/Default.aspx14-May-2012AbstractAge‐related memory loss is considered to commence at middle‐age and coincides with reduced adult hippocampal neurogenesis and neurotrophin levels. Consistent physical activity at midlife may preserve brain‐derived neurotrophic factor (BDNF) levels, new cell genesis, and learning. In the...http://www.medconnect.com.my/tabid/100/ct9/c458167/Running-throughout-middle-age-improves-memory-function-hippocampal-neurogenesis-and/Default.aspx14-May-2012Conclusion In MS with limiting symptoms despite unimpressive findings at rest, valvular capacity exhaustion should be tested on a dynamic background, as no single resting index can predict potential haemodynamic adaptation to exercise. In such context, the contribution of exercise echocardiography...http://www.medconnect.com.my/tabid/100/ct9/c458168/Dynamic-assessment-of-valvular-reserve-capacity-in-patients-with/Default.aspx14-May-2012Conclusions: The current study uncovered several factors associated with ADHD at the national level, including some that have not been studied earlier in such a setting. However, we caution that due to the cross-sectional and observational nature of the data, a cause and effect relationship between...http://www.medconnect.com.my/tabid/100/ct9/c458169/Factors-associated-with-attention-deficit-hyperactivity-disorder-among-US-children-/Default.aspx14-May-2012The purpose of this study was to analyze the participation and performance trends of male triathletes in the “Ironman Switzerland” from 1995 to 2010. Participation trends of all finishers aged between 18 and 64 years were analyzed over the 16‐year period by considering four 4‐year periods...http://www.medconnect.com.my/tabid/100/ct9/c458170/Master-triathletes-have-not-reached-limits-in-their-Ironman-triathlon-performance/Default.aspx14-May-2012IntroductionIn early rheumatoid arthritis (RA), low-dose oral prednisone (PDN) co-medication yields better clinical results than monotherapy with disease modifying antirheumatic drugs (DMARDs). In addition, ultrasonographic (US) evaluation reveals rapid and significative effects of...http://www.medconnect.com.my/tabid/100/ct9/c458103/Low-dose-oral-prednisone-improves-clinical-and-ultrasonographic-remission-rates/Default.aspx14-May-2012Conclusions: Cleavage of collagen by proteases usually arises pericellularly around chondrocytes at and near the articular surface, subsequently becoming more intense and extending progressively deeper into the cartilage with ageing and OA. The close correspondence between the distributions of...http://www.medconnect.com.my/tabid/100/ct9/c458104/Increased-type-II-collagen-cleavage-by-cathepsin-K-and/Default.aspx14-May-2012Conclusions: The increased presence of citrullinated peptides in RA patients points towards a possible specific role of these peptides in the immune response at the basis of the recognition of citrullinated peptides and proteins by RA patient autoantibodies. (Source: Arthritis Research and Therapy)http://www.medconnect.com.my/tabid/100/ct9/c458105/Elevated-levels-of-fibrinogen-derived-endogenous-citrullinated-peptides-in-synovial/Default.aspx14-May-2012Conclusions: Both HDL subfractions but particularly HDL2-chol concentrations were decreased in RA, primarily in women. This seems to be associated with disease activity and is of clinical relevance. The reduction of the HDL subfraction concentrations, particularly the supposedly beneficial...http://www.medconnect.com.my/tabid/100/ct9/c458106/High-density-lipoprotein-cholesterol-subfractions-HDL2-and-HDL3-are-reduced/Default.aspx14-May-2012Only after biological response modifiers have become available have we begun to understand some of the complex functions of TNF in the human immune system. TNF is clearly essential for fighting intracellular pathogens, but probably not essential for fighting tumors. TNF influence on the humoral...http://www.medconnect.com.my/tabid/100/ct9/c458107/Vaccination-under-TNF-blockade-less-effective-but-worthwhile/Default.aspx14-May-2012Conclusions: Analysis of gene expression patterns of lifecycle in B. malayi has provided novel insights intothe biology of filarial parasites. Proteins encoded by stage-associated and/or stage-specifictranscripts are likely to be critically important for key parasite functions such asestablishment...http://www.medconnect.com.my/tabid/100/ct9/c459176/Transcription-profiling-reveals-stage-and-functiondependent-expression-patterns-in/Default.aspx14-May-2012The first lady is partnering with the U.S. Olympic Committee, the Partnership for a Healthier America, U.S. Paralympics and numerous national governing bodies that have pledged their time and resources toward introducing young people to their sports over the course of the summer. (Source: RWJF News...http://www.medconnect.com.my/tabid/100/ct9/c459177/First-Lady-Has-Plan-to-Get-Kids-Involved-in-Sports/Default.aspx14-May-2012CONCLUSIONS: The findings indicate a high prevalence of overweight/obesity in these Iranian adolescents, particularly the boys. The influence of physical activity and diet on overweight/obesity requires further prospective studies. PMID: 22578771 [PubMed - as supplied by publisher] (Source: Public...http://www.medconnect.com.my/tabid/100/ct9/c459716/Prevalences-of-overweight-and-obesity-and-their-association-with/Default.aspx14-May-2012Conclusions: Simvastatin modulates the gene expression of selected IL-13-inducible pro-inflammatorycytokines and chemokines in primary mouse tracheal epithelial cells. The airway epitheliummay be a viable target tissue for the statin drugs. Further research is needed to assess themechanisms of how...http://www.medconnect.com.my/tabid/100/ct9/c459128/Differential-effects-of-simvastatin-on-IL-13-induced-cytokine-gene-expression/Default.aspx14-May-2012Ballard-Barbash R. J Natl Cancer Inst. 2012;doi:10.1093/jnci/djs207. (Source: HemOncToday.com)http://www.medconnect.com.my/tabid/100/ct9/c460931/Exercise-improved-survival-in-those-with-breast-colon-cancer/Default.aspx14-May-2012Abstract  Previous researchers have found that 10-form Tai chi yields symptomatic benefit in patients with fibromyalgia (FM). The purpose of this study was to further investigate earlier findings and add a focus on functional mobility. We conducted a parallel-group randomized controlled...http://www.medconnect.com.my/tabid/100/ct9/c459178/A-randomized-controlled-trial-of-8-form-Tai-chi-improves/Default.aspx13-May-2012Conclusion  The present study shows that caudate D2/3 receptors play an important role in the development of quinpirole-induced hyperdipsia, an animal model of psychotic polydipsia. Content Type Journal ArticleCategory Original InvestigationPages 1-7DOI...http://www.medconnect.com.my/tabid/100/ct9/c459089/Increased-drinking-after-intra-striatal-injection-of-the-dopamine-D2-D3/Default.aspx13-May-2012Conclusions  SFST were mildly sensitive to impairment from cannabis in heavy users. Lack of sensitivity might be attributed to tolerance and time of testing. SFST were sensitive to both doses of alcohol. The Dräger Drug Test® 5000 appears to be a promising tool for detecting THC in oral...http://www.medconnect.com.my/tabid/100/ct9/c459091/A-placebo-controlled-study-to-assess-Standardized-Field-Sobriety-Tests/Default.aspx13-May-2012Conclusion  The authors’ experience has shown that SPLS TEP groin hernia repair is a feasible and safe alternative to three-port laparoscopic hernia repairs in a large patient cohort. There were minimal post-operative complications and good post-operative outcome. Recurrence rate was...http://www.medconnect.com.my/tabid/100/ct9/c459179/Single-port-hernia-repair-a-prospective-cohort-of-102-patients/Default.aspx13-May-2012Conclusion  Crural closure reinforcement during hiatal hernia repair can be done readily with this new bioabsorbable polymer–based mesh. Fibrin glue fixation of this new prosthetic can be done quickly and it creates a strong, fixed barrier that may decrease the chance of erosion....http://www.medconnect.com.my/tabid/100/ct9/c459180/A-technique-for-placement-of-a-bioabsorbable-prosthesis-with-fibrin/Default.aspx13-May-2012